Method and system for displaying blood flow

• US 8,000,768 B2
• Filed: 01/10/2005
• Issued: 08/16/2011
• Est. Priority Date: 01/10/2005
• Status: Active Grant

• Current Assignee: VasSol Inc.
• Original Assignee: VasSol Inc.
• Inventors: Meng, Ning, Zhao, Meide, Curcio, Anthony
• Primary Examiner(s): Cattungal; Sanjay
• Application Number:
  US11/032,306
• Publication Number:
  US 20060155187A1
• Time in Patent Office: 2,409 Days
• Field of Search: 600407-420, 324307-309
• US Class Current: 600/410
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 8/543 involving acquisition triggered by a physiological signal
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

A method and system are disclosed for presenting anatomical and blood flow information contained in a magnetic resonance imaging (MRI) dataset. A three-dimensional (3D) representation of blood flow is generated which varies with time, referred to herein as a four-dimensional (4D) presentation or display. The system allows the visualization of the dynamics of blood flow and the visualization of anatomical information via the fusion of different types of MRI data sets.

Claims

1. A method for displaying blood flow, comprising:

generating a temporal sequence of 2D phase images representing blood flow through a selected anatomical plane using PCMR imaging, wherein each 2D phase image is made up of pixels with each pixel having an intensity corresponding to the phase of a spin density function at the location of the pixel;

for each 2D phase image, deriving a 3D flow image by mapping location and size information of one or more pixels in the 2D phase image into coordinates of a surface element in an X-Y plane corresponding to the anatomical plane and mapping the intensity of the one or more pixels into a height or Z coordinate for the surface element so that the 3D flow image includes one or more flow surfaces plotted above or below the anatomical plane at a height corresponding to the phase in the 2D phase image;

creating a temporal sequence of the derived 3D flow images that correspond to the temporal sequence of 2D phase images; and

,

displaying the sequence of 3D flow images serially to form a four-dimensional flow presentation.

2. The method of claim 1 wherein the height of the flow surface in the 3D flow image corresponds to the phase of the underlying or overlying pixel in the 2D flow image.

3. The method of claim 1 wherein the height of the flow surface in the 3D flow image corresponds to the phase of a group of underlying or overlying pixels in the 2D flow image.

4. The method of claim 1 wherein a 3D flow image is created for each 2D phase image to generate the temporal sequence of 3D flow images.

5. The method of claim 1 wherein a 3D flow image is created for a 2D phase image and then updated with information from subsequent 2D phase images to generate the temporal sequence of 3D flow images.

6. The method of claim 1 further comprising displaying the temporal sequence of 3D flow images at uniformly spaced time intervals.

7. The method of claim 1 further comprising displaying the temporal sequence of 3D flow images at time intervals corresponding to the real-time intervals at which the corresponding phase images were acquired.

8. The method of claim 1 further comprising transmitting the temporal sequence of 3D flow images over a network in the form of pages viewable by browser software.

9. The method of claim 1 further comprising encoding the temporal sequence of 3D flow images into a video format for storage in a persistent medium.

10. The method of claim 1 further comprising selectively flattening one or more flow surfaces in the 3D flow image.

11. The method of claim 1 further comprising:

generating a 3D image of selected blood vessels which pass through the selected anatomical plane where the vessels are rendered as transparent conduits; and

,

superposing the 3D image of the selected blood vessels with the 3D flow images so that the flow surfaces are contained within the vessels.

12. The method of claim 11 wherein the 3D image of selected blood vessels is generated using TOF magnetic resonance imaging.

13. The method of claim 1 further comprising:

generating a 2D magnitude image of the selected anatomical plane using MRI; and

,

displaying the flow surfaces of the 3D flow images with pixel intensities matching the corresponding pixel intensities of the 2D magnitude image.

14. The method of claim 13 wherein the pixel intensities are color mapped to a range of colors.

15. The method of claim 13 wherein the pixel intensities are gray scale mapped to a shade of black and white.

16. The method of claim 1 wherein the temporal sequence of 2D phase images is synchronized to the cardiac cycle.

17. The method of claim 16 wherein each successive pair of 2D phase images in the temporal sequence represents a systolic phase and a diastolic phase of the cardiac cycle.

18. The method of claim 16 wherein each 2D phase image of the temporal sequence represents the same phase of the cardiac cycle.

19. A system for displaying blood flow, comprising:

an MRI system configured to generate a temporal sequence of 2D phase images representing blood flow through a selected anatomical plane using PCMR imaging, wherein each 2D phase image is made up of pixels with each pixel having an intensity corresponding to the phase of a spin density function at the location of the pixel;

a computer programmed to;

     1) for each 2D phase image, derive a 3D flow image by mapping location and size information of one or more pixels in the 2D phase image into coordinates of a surface element in an X-Y plane corresponding to the anatomical plane and mapping the intensity of the one or more pixels into a height or Z coordinate for the surface element so that the 3D flow image includes one or more flow surfaces plotted above or below the anatomical plane at a height corresponding to the phase in the 2D phase image, and

     2) create a temporal sequence of the derived 3D flow images that correspond to the temporal sequence of 2D phase images; and

,

wherein the computer is further programmed to display the sequence of 3D flow images serially to form a four-dimensional flow presentation.

20. The system of claim 19 wherein the computer is further programmed to transmit the temporal sequence of 3D flow images over a network in the form of pages viewable by browser software.

21. The system of claim 19 wherein:

the MRI system is further configured to generate a 2D magnitude image of the selected anatomical plane using MRI; and

,

the computer is further programmed to display the flow surfaces of the 3D flow images with pixel intensities matching the corresponding pixel intensities of the 2D magnitude image.

22. The system of claim 21 wherein the pixel intensities are color mapped to a range of colors.

23. The system of claim 19 wherein the MRI system is further configured to:

generate a 3D image of selected blood vessels which pass through the selected anatomical plane where the vessels are rendered as transparent conduits; and

,

superpose the 3D image of the selected blood vessels with the 3D flow images so that the flow surfaces are contained within the vessels.

24. The system of claim 23 wherein the 3D image of selected blood vessels is generated using TOF magnetic resonance imaging.

25. A non-transitory computer-readable storage medium containing instructions for:

creating a temporal sequence of 3D flow images from a temporal sequence of 2D phase images representing blood flow through a selected anatomical plane using PCMR imaging, wherein each 2D phase image is made up of pixels with each pixel having an intensity corresponding to the phase of a spin density function at the location of the pixel, by;

     1) for each 2D phase image, deriving a 3D flow image by mapping location and size information of one or more pixels in the 2D phase image into coordinates of a surface element in an X-Y plane corresponding to the anatomical plane and mapping the intensity of the one or more pixels into a height or Z coordinate for the surface element so that the 3D flow image includes one or more flow surfaces plotted above or below the anatomical plane at a height corresponding to the phase in the 2D phase image, and

     2) create a temporal sequence of the derived 3D flow images that correspond to the temporal sequence of 2D phase images; and

,

displaying the sequence of 3D flow images serially to form a four-dimensional flow presentation.