Detection of myocardial ischemia from the time sequence of implanted sensor measurements
First Claim
1. A system comprising:
- a plurality of sensors, each sensor operable to produce an electrical sensor signal related to physiologic cardiovascular events of a subject, and wherein at least one of the sensors is capable of being implanted into the subject; and
a processor in communication with the implantable sensors, wherein the processor comprises;
an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of the subject and a time difference between detected events, wherein the time-wise cascade includes at least first, second, and third physiologic cardiovascular events; and
a decision module to declare whether an ischemic event occurred using a determined order of occurrence of, and the time difference between occurrence of, the first, second, and third physiologic cardiovascular events; and
a response circuit, coupled to the decision module, the response circuit operable to provide a specified response if the ischemic event is declared.
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Abstract
A system including a plurality of implantable sensors, a processor, and a response circuit. Each sensor produces an electrical sensor signal related to physiologic cardiovascular events of a subject. The processor includes an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of a subject and a decision module. The time-wise cascade includes at least first, second, and third physiologic cardiovascular events. The decision module declares whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events. The response circuit provides a specified response if the ischemic event is declared.
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Citations
30 Claims
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1. A system comprising:
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a plurality of sensors, each sensor operable to produce an electrical sensor signal related to physiologic cardiovascular events of a subject, and wherein at least one of the sensors is capable of being implanted into the subject; and a processor in communication with the implantable sensors, wherein the processor comprises; an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of the subject and a time difference between detected events, wherein the time-wise cascade includes at least first, second, and third physiologic cardiovascular events; and a decision module to declare whether an ischemic event occurred using a determined order of occurrence of, and the time difference between occurrence of, the first, second, and third physiologic cardiovascular events; and a response circuit, coupled to the decision module, the response circuit operable to provide a specified response if the ischemic event is declared. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of operating a device comprising:
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sensing at least first, second and third sensor signals using the device, each sensor signal including physiologic cardiovascular information and at least one sensor signal provided by an implantable sensor; detecting, using the device, a time-wise sequential cascade of at least first, second, and third physiologic cardiovascular events from the first, second, and third implantable sensor signals and a time difference between detected events; declaring, using the device, whether an ischemic event occurred from a determined order of occurrence of, and the time difference between occurrence of, the first, second, and third physiologic cardiovascular events; and providing a specified device response if the ischemic event is declared. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification