Electrode array for neural stimulation

• US 8,000,804 B1
• Filed: 10/27/2006
• Issued: 08/16/2011
• Est. Priority Date: 10/27/2006
• Status: Active Grant

• Current Assignee: National Technology & Engineering Solutions Of Sandia LLC (Honeywell International Inc.)
• Original Assignee: Sandia Corporation (Martin Marietta Corporation)
• Inventors: Stein, David J., Wessendorf, Kurt O., Dellinger, Jennifer, Yang, Pin, Cesarano, Joseph III, Okandan, Murat
• Primary Examiner(s): Patel; Niketa I
• Assistant Examiner(s): HOLMES, REX R
• Application Number:
  US11/588,905
• Time in Patent Office: 1,754 Days
• Field of Search: 607 53- 54, 607115-116
• US Class Current: 607/116
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye

Abstract

An electrode array for neural stimulation is disclosed which has particular applications for use in a retinal prosthesis. The electrode array can be formed as a hermetically-sealed two-part ceramic package which includes an electronic circuit such as a demultiplexer circuit encapsulated therein. A relatively large number (up to 1000 or more) of individually-addressable electrodes are provided on a curved surface of a ceramic base portion the electrode array, while a much smaller number of electrical connections are provided on a ceramic lid of the electrode array. The base and lid can be attached using a metal-to-metal seal formed by laser brazing. Electrical connections to the electrode array can be provided by a flexible ribbon cable which can also be used to secure the electrode array in place.

Claims

1. An electrode array for neural stimulation, comprising:

a two-part ceramic package further comprising a ceramic base and a ceramic lid, with the ceramic base and the ceramic lid each having a pair of major surfaces and with at least one of the ceramic base and the ceramic lid having a ceramic lip extending outward therefrom to define an interior region between the ceramic base and the ceramic lid, and with the ceramic lid having a plurality of electrical connections extending between the pair of major surfaces thereof, and with the ceramic base having a plurality of electrodes extending between the pair of major surfaces thereof; and

an electronic circuit located within the interior region to receive electrical input signals conducted through the plurality of electrical connections and to generate therefrom electrical output signals which are communicated to the plurality of electrodes for use in neural stimulation.

2. The electrode array of claim 1 wherein the major surface of the ceramic base outside of the interior region is a curved surface.

3. The electrode array of claim 2 wherein the two-part ceramic package has a circular shape.

4. The electrode array of claim 1 wherein the ceramic base is attached to the ceramic lid by a metal-to-metal seal formed therebetween.

5. The electrode array of claim 1 further comprising a plurality of electrical interconnections extending between the electrical connections in the ceramic lid and a plurality of contact pads located on the electronic circuit or on the major surface of the ceramic base inside the interior region to further conduct the electrical input signals to the electronic circuit.

6. The electrode array of claim 1 wherein the electrodes comprise metal.

7. The electrode array of claim 1 wherein each electrode is overcoated with a layer of platinum on an exposed end thereof outside of the interior region.

8. The electrode array of claim 1 wherein the electrodes comprise sintered metal electrodes.

9. The electrode array of claim 1 wherein the electrodes comprise a sintered mixture of ceramic and metal.

10. The electrode array of claim 1 wherein the electronic circuit comprises a demultiplexer circuit.

11. The electrode array of claim 1 wherein the ceramic base and the ceramic lid are formed from a ceramic material which comprises 50-80 percent by volume zirconium oxide and 50-20 percent by volume aluminum oxide.

12. An electrode array for neural stimulation, comprising:

a ceramic base having a first major surface and a second major surface, with the first major surface being curved, and with a ceramic lip located about a curved edge of the second major surface and extending towards the first major surface, and with a plurality of electrodes arranged in a two-dimensional array and extending through the ceramic base between the first and second major surfaces;

a ceramic lid having a plurality of electrical connections extending therethrough, with the ceramic lid being attachable to the ceramic base to form a hermetically-sealed interior region; and

an electronic circuit located within the hermetically-sealed interior region and having a plurality of input ports and a plurality of output ports, with the input ports being connected to the electrical connections in the ceramic lid, and with the output ports being connected to the electrodes in the ceramic base to provide electrical output signals to the electrodes for neural stimulation in response to electrical input signals provided to the input ports of the electronic circuit.

13. The electrode array of claim 12 wherein the ceramic base and ceramic lid are both circular in shape with a diameter, of a few millimeters.

14. The electrode array of claim 12 wherein the ceramic base and the ceramic lid comprise a ceramic material which further comprises 50-80 percent by volume zirconium oxide and 50-20 percent by volume aluminum oxide.

15. The electrode array of claim 12 wherein the first major surface has a surface radius of curvature which is adapted to provide contact with an inner surface of a human retina.

16. The electrode array of claim 12 wherein the electrodes comprise metal.

17. The electrode array of claim 12 wherein the electrodes comprise sintered metal electrodes.

18. The electrode array of claim 12 wherein the electrodes comprise a sintered mixture of ceramic and metal.

19. The electrode array of claim 12 wherein the electrodes are overcoated with a layer of platinum on at least one end thereof.

20. The electrode array of claim 12 wherein the electrical connections in the ceramic lid comprise metal.

21. The electrode array of claim 12 wherein each output port is connected to one of the electrodes in the ceramic base by solder.

22. The electrode array of claim 12 wherein each input port is connected to one of the electrical connections in the ceramic lid by solder.

23. The electrode array of claim 12 wherein each input port is connected to one of the electrical connections in the ceramic lid by an electrically-conductive epoxy.

24. The electrode array of claim 12 wherein each input port is connected to one of the electrical connections in the ceramic lid by an electrically-conductive spring.

25. The electrode array of claim 12 wherein each input port is connected to one of the electrical connections in the ceramic lid by a deformable metal pin.

26. The electrode array of claim 12 wherein each input port is connected to one of the electrical connections in the ceramic lid via a contact pad formed on the second major surface of the ceramic base.

27. The electrode array of claim 12 wherein the ceramic lid is attachable to the ceramic base by a metal annulus formed on the ceramic lip and another metal annulus formed on the ceramic lid, with the two metal annuluses being brazed together.

28. The electrode array of claim 27 wherein the ceramic lid comprises another ceramic lip extending outward from a major surface thereof towards the ceramic body, with the metal annulus on the ceramic lid being formed on the ceramic lip thereof.

29. The electrode array of claim 12 wherein the electronic circuit comprises a demultiplexer circuit.

30. An electrode array for neural stimulation comprising a two-part ceramic package having a ceramic base and a ceramic lid, with the ceramic base having a plurality of electrodes formed therein as a part of the ceramic base prior to the insertion of an electronic circuit into the two-part ceramic package, and with the ceramic lid having a plurality of electrical connections formed therein as a part of the ceramic lid prior to the insertion of the electronic circuit, and with at least one of the ceramic base and the ceramic lid having a ceramic lip extending outward therefrom to define an interior region between the ceramic base and the ceramic lid for insertion of the electronic circuit, and with the electronic circuit having input ports connected to the plurality of electrical connections to receive electrical input signals into the electronic circuit, and with the electronic circuit having output ports to provide output signals to the plurality of electrodes for neural stimulation.

31. The electrode array of claim 30 wherein the ceramic base is attached to the ceramic lid by a metal-to-metal seal formed therebetween.

32. The electrode array of claim 30 wherein the electronic circuit comprises a demultiplexer circuit.