Irradiation verification device for radiotherapy installations, and method for handling thereof

• US 8,002,466 B2
• Filed: 03/12/2007
• Issued: 08/23/2011
• Est. Priority Date: 03/13/2006
• Status: Expired due to Fees

• Current Assignee: Gessellschaft Fur Schwerionenforschung MbH
• Original Assignee: Gessellschaft Fur Schwerionenforschung MbH
• Inventors: Von Neubeck, Cläre Hanna, Hartel, Carola Sabine, Kraft-Weyrather, Wilma
• Primary Examiner(s): Ho; Allen C.
• Application Number:
  US12/225,197
• Publication Number:
  US 20090274273A1
• Time in Patent Office: 1,625 Days
• Field of Search: 378/18, 378/64, 378/65, 378/207, 250/252.1, 250/472.1
• US Class Current: 378/207
• CPC Class Codes: A61N 2005/1076 using a dummy object placed in the radiation field, e.g. phantom
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/1071 for verifying the dose delivered by the treatment plan
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates

Abstract

The present invention relates to an irradiation verification apparatus containing living cell material which is fixed in location on cell supports which are arranged between cell support holders. For irradiation verification, the z co-ordinate of the irradiation verification apparatus is adjusted in the direction of the beam axis Z so that, after irradiation, regions having killed cell material can be demarcated in spatial co-ordinates, with reference to an irradiation scheme, from regions having cell material of the irradiation verification apparatus that is still active. A container having an insert for the cell supports and also the cell support holders comprise a beam-transparent material. The cell support holders have a base plate and a top plate, between which the cell supports are arranged orthogonally to the holding plates.

Claims

1. Irradiation verification apparatus for beam therapy systems, the irradiation verification apparatus comprising:

a container having an insert comprising cell support holders and cell supports,

wherein living cell material is fixed in location in the three spatial co-ordinates x, y and z in the container having the insert, on the cell supports of the insert,

wherein the cell supports are arranged between the cell support holders and, for irradiation verification, the z co-ordinate of the irradiation verification apparatus is adjusted in the direction of the beam axis Z such that, after the irradiation, regions having killed cell material can be demarcated in spatial co-ordinates, with reference to an irradiation scheme, from regions having cell material of the irradiation verification apparatus that is still active,

wherein the container having the insert and the cell supports and the cell support holders comprise a beam-transparent material,

wherein the cell support holders have a base plate and a top plate located opposite the base plate, between which the cell supports are arranged orthogonally to holding plates, the holding plates having blind holes aligned with one another, in which ends of the cell supports are arranged, and

wherein the cell supports are solid rods, on the outer surfaces of which the cell material is fixed.

2. Irradiation verification apparatus according to claim 1, wherein the cell supports comprise neither metals nor elements having a higher atomic mass number than oxygen, have a density close to water of about 1 g/cm³.

3. Irradiation verification apparatus according to claim 2, wherein the cell supports are arranged between the holding plates in rows offset from one another.

4. Irradiation verification apparatus according to claim 2, wherein the cell supports have a length I of 25 mm≦

I≦

75 mm.

5. Irradiation verification apparatus according to claim 1, wherein the cell supports have a diameter d in millimeters between 1.0 mm≦

d≦

5 mm.

6. Irradiation verification apparatus according to claim 1, wherein the minimum spacing a in millimeters between the cell supports is between 0.5 mm ≦

a≦

5 mm.

7. Irradiation verification apparatus according to claim 1, wherein between the holding plates there are arranged at least three spacers.

8. Irradiation verification apparatus according to claim 1, wherein the spacers are arranged between projections on peripheral sides of the holding plates.

9. Irradiation verification apparatus according to claim 1, wherein the base plate has deeper blind holes for fixing one end of the solid rods than the top plate.

10. Irradiation verification apparatus according to claim 1, wherein the blind holes of the holding plates have a tapered countersink of the outer edge.

11. Irradiation verification apparatus according to claim 1, wherein at least one of the holding plates has through-holes distributed between the blind holes on the upper side.

12. Irradiation verification apparatus according to claim 1, wherein the holding plates have markings for identifying the positions of the cell supports.

13. Irradiation verification apparatus according to claim 1, wherein the insert has standing legs directed to the base region of the container.

14. Irradiation verification apparatus according to claim 1, wherein the container has an inlet aperture and an outlet aperture for one or more of a nutrient liquid and gas(es).

15. Irradiation verification apparatus according to claim 14, wherein one of the one or more gases is oxygen.

16. Irradiation verification apparatus according to claim 1, wherein the container has a cylindrical inner wall and, in the base region, at least one stirring apparatus for the distribution of nutrient liquid to the living cell material on the outer surfaces of the rod-shaped cell supports.

17. Irradiation verification apparatus according to claim 1, wherein the irradiation verification apparatus has, in the direction of the y spatial co-ordinate, a higher location resolution for a Y deflection direction of the beam than in the direction of the x spatial co-ordinate for the X deflection direction of the beam.

18. Irradiation verification apparatus according to claim 1, wherein the irradiation verification apparatus has, in the direction of the z spatial co-ordinate, the same location resolution for the Z propagation direction of the beam as in the direction of the x spatial co-ordinate for the X deflection direction of the beam.

19. Irradiation verification apparatus according to claim 1, wherein the irradiation verification apparatus has a number S of cell supports (3) of 150≦

S≦

900.

20. A method for operation of an irradiation verification apparatus comprising:

providing outer surfaces of rod-shaped cell supports with active living cell material,

assembling of an insert with a container of the irradiation verification apparatus, with arrangement of the cell supports having living cell material between two holding plates of the insert and securing of the assembled insert by means of spacers,

filling the container with nutrient liquid,

introducing the insert into the container,

supplying one or more gases by way of an inlet aperture, to the container,

orienting the x, y and z spatial co-ordinates of the irradiation verification apparatus relative to the beam direction,

implementing a planned irradiation scheme, with simultaneous or subsequent temperature control of the nutrient liquid in order to preserve the results,

disassembling of the cell supports from the insert,

separating the rod-shaped cell supports into slices and detection of the still living cell material on the separated slices,

comparing the results with reference to the selected analytical end-points and the irradiation plan.

21. The method of claim 20, wherein the irradiation verification apparatus comprises:

living cell material fixed in location in the three spatial co-ordinates x, y and z in a container having an insert, on cell supports of the insert, the cell supports being arranged between cell support holders and, for irradiation verification, the z co-ordinate of the irradiation verification apparatus being adjusted in the direction of the beam axis Z so that, after the irradiation, regions having killed cell material can be demarcated in spatial co-ordinates, with reference to an irradiation scheme, from regions having cell material of the irradiation verification apparatus that is still active,

wherein;

the container having the insert and the cell supports and the cell support holders comprise a beam-transparent material,

the cell support holders have a base plate and a top plate located opposite the base plate, between which the cell supports are arranged orthogonally to the holding plates, the holding plates having blind holes aligned with one another, in which the ends of the cell supports are arranged,

the cell supports are solid rods, and

the cell material is fixed on the outer surfaces of the cell supports.

22. The method of claim 20, wherein one of the one or more gases is oxygen.