Self-contained pressurized injection device

• US 8,002,753 B2
• Filed: 12/22/2008
• Issued: 08/23/2011
• Est. Priority Date: 12/21/2007
• Status: Active Grant

• Current Assignee: Nordson Corporation
• Original Assignee: Nordson Corporation
• Inventors: Krumme, John F., Field, Leslie A.
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Zhang; Jenna
• Application Number:
  US12/340,920
• Publication Number:
  US 20090177158A1
• Time in Patent Office: 974 Days
• Field of Search: 604 82- 89, 604245-249, 604/99.04, 60416703-16705, 604/236, 604/69, 604/70, 604140-148, 60416701-16706, 604/250, 604/255, 604/181, 604/186, 604/207, 604/214
• US Class Current: 604/207
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2205/6081 Colour codes
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/16881 Regulating valves on-off valves, e.g. clamps A61M39/28
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155

Abstract

An apparatus includes a medicament container and an actuator assembly coupled to a proximal end portion of the medicament container. A distal end portion of the medicament container is configured to be coupled to a needle. A piston is movably disposed within the medicament container such that the medicament container is divided into a first internal portion and a second internal portion, the first internal portion containing a medicament. The actuator assembly has a pressurized fluid container, a regulator and a bias member. The pressurized fluid container is configured to move relative to the medicament container between a first position and a second position. The regulator is configured to fluidically couple the pressurized fluid container and the second internal portion of the medicament container when the pressurized fluid container is in the second position. The bias member is configured to bias the pressurized fluid container in the first position.

Claims

1. An apparatus, comprising:

a medicament container having a distal end portion and a proximal end portion, and a longitudinal axis extending through the distal end portion and the proximal end portion, the distal end portion configured to be coupled to a needle;

a piston movably disposed within the medicament container such that the medicament container is divided into a first internal portion and a second internal portion, the first internal portion configured to contain a medicament;

a pressurized fluid container coupled to the proximal end portion of the medicament container and containing a pressurized fluid;

a flow regulator positioned between the medicament container and the pressurized fluid container, the flow regulator configured to be opened to selectively place the pressurized fluid container in fluid communication with the second internal portion of the medicament container such that the pressurized fluid fills the second internal portion and directly applies a force on the piston to move the piston toward the distal end portion of the medicament container; and

a valve mechanism coupled to the distal end portion of the medicament container, the valve mechanism configured to selectively restrict a flow path between the first internal portion of the medicament container and the needle, the valve mechanism including an actuator configured to move in a direction substantially normal to the longitudinal axis;

of the medicament container to actuate the valve mechanism.

2. The apparatus of claim 1, wherein:

the valve mechanism includes a valve body and a valve member, the valve body defining at least a portion of the flow path, the valve member movably disposed within the valve body, the actuator configured to move the valve member in a direction substantially parallel to the longitudinal axis of the medicament container to actuate the valve mechanism.

3. The apparatus of claim 1, wherein the valve mechanism includes an elastic tube and a constricting member, the elastic tube defining at least a portion of the flow path, the constricting member configured to be disposed about a portion of the elastic tube, the constricting member configured to deform at least a portion of the elastic tube;

to restrict the flow path between the first internal portion of the medicament container and the needle.

4. The apparatus of claim 1, wherein the valve mechanism includes a valve body and a valve member, the valve body defining at least a portion of the flow path, the actuator configured to rotate the valve member within the valve body about an axis substantially normal to the longitudinal axis of the medicament container when the actuator is moved.

5. The apparatus of claim 1, wherein the valve mechanism includes a valve body defining at least a portion of the flow path, a portion of the valve body disposed within a hub of the needle when the distal end portion of the medicament container is coupled to the needle.

6. The apparatus of claim 1, wherein the valve mechanism includes a valve body and a coupler coupled to the valve body, the valve body defining at least a portion of the flow path, the coupler configured to removably couple the distal end portion of the medicament container to the needle such that the needle is in fluid communication with the flow path.

7. The apparatus of claim 1, wherein the valve mechanism includes a valve body, a valve member and a valve seat, the valve body defining at least a portion of the flow path, the valve member configured to move within the valve body between a first position and a second position when the valve mechanism is actuated, the valve member in contact with a first portion of the valve seat when the valve member is in the first position, the valve member deforming a second portion of the valve seat when the valve member is in the second position, wherein the second portion of the valve seat applies a biasing force to the valve member when deformed to urge the valve member back to the first position.

8. The apparatus of claim 1, further comprising:

an adapter operatively disposed between the pressurized fluid container and the proximal end portion of the medicament container, the adapter configured to amplify a first pressure produced by the pressurized fluid container such that the medicament within the first internal portion of the medicament container is at a second pressure higher than the first pressure.

9. The apparatus of claim 1, wherein the pressurized fluid container includes a fluid having a vapor pressure of at least approximately 517 kilopascals at 21 degrees Celsius.

10. The apparatus of claim 1, wherein the valve mechanism further includes a valve body including a slot and a tube defining at least a portion of the flow path between the first internal portion of the medicament container and the needle, and wherein the actuator includes an outer peripheral surface and a protrusion engaged with the slot, the outer peripheral surface configured to clamp the tube and the flow path as the protrusion moves along the slot.

11. The apparatus of claim 10, wherein the slot is disposed at an acute, non-zero angle from the tube such that movement of the actuator and the protrusion along the slot toward the tube gradually clamps the tube and the flow path.

12. An apparatus, comprising

a medicament container having a distal end portion and a proximal end portion, and a longitudinal axis extending through the distal end portion and the proximal end portion, the distal end portion configured to be coupled to a needle;

a piston movably disposed within the medicament container such that the medicament container is divided into a first internal portion and a second internal portion, the first internal portion configured to contain a medicament;

a pressurized fluid container coupled to the proximal end portion of the medicament container such that the pressurized fluid container can selectively be placed in fluid communication with the second internal portion of the medicament container; and

a valve mechanism coupled to the distal end portion of the medicament container, the valve mechanism configured to control a flow of the medicament from the first internal portion to the needle, the valve mechanism including a valve body, a valve member, and a valve seat including a first portion and a second portion, the valve member configured to move within the valve body in a direction substantially parallel to the longitudinal axis of the medicament container between a first position and a second position when the valve mechanism is actuated, the valve member being in contact with the first portion of the valve seat when the valve member is in the first position, the valve member deforming the second portion of the valve seat when the valve member is in the second position,

wherein the second portion of the valve seat applies a biasing force to the valve member when deformed to urge the valve member back to the first position.

13. The apparatus of claim 12, wherein the valve mechanism includes an actuator configured to move in a direction substantially normal to the longitudinal axis of the medicament container to actuate the valve mechanism.

14. The apparatus of claim 12, wherein a portion of the valve body is disposed within a hub of the needle when the distal end portion of the medicament container is coupled to the needle.

15. The apparatus of claim 12, wherein the valve mechanism includes a coupler coupled to the valve body, the coupler configured to removably couple the distal end portion of the medicament container to the needle such that the needle is in fluid communication with the flow path.

16. An apparatus, comprising:

a medicament container having a distal end portion and a proximal end portion and a longitudinal axis extending through the distal end portion and the proximal end portion, the distal end portion configured to be coupled to a needle;

a piston movably disposed within the medicament container such that the medicament container is divided into a first internal portion and a second internal portion, the first internal portion configured to contain a medicament, the proximal end portion of the medicament container configured to be coupled to a pressurized fluid container such that the pressurized fluid container can be placed in fluid communication with the second internal portion of the medicament container; and

a valve mechanism coupled to the distal end portion of the medicament container, the valve mechanism including a valve body, a compressible tube, a valve member configured to rotate within the valve body, and an actuator coupled to the valve member, the valve member defining a lumen having first and second ends, the lumen receiving a portion of the tube, the tube extending beyond the first and second ends of the lumen and defining at least a portion of a flow path between the first internal portion of the medicament container and the needle, and the actuator being configured to move in a direction substantially normal to the longitudinal axis of the medicament container to rotate the valve member and pinch the compressible tube to restrict the flow of medicament through the needle.

17. The apparatus of claim 16, wherein a portion of the valve body is disposed within a hub of the needle when the distal end portion of the medicament container is coupled to the needle.

18. The apparatus of claim 16, wherein the valve mechanism includes a coupler coupled to the valve body, the coupler configured to removably couple the distal end portion of the medicament container to the needle such that the needle is in fluid communication with the flow path.

19. The apparatus of claim 16, further comprising:

an adapter operatively disposed between the pressurized fluid container and the proximal end portion of the medicament container, the adapter configured to amplify a first pressure produced by the pressurized fluid container such that the medicament within the first internal portion of the medicament container is at a second pressure higher than the first pressure.