Fluid analytical device

• US 8,002,995 B2
• Filed: 04/01/2008
• Issued: 08/23/2011
• Est. Priority Date: 11/02/2007
• Status: Active Grant

• Current Assignee: Industrial Technology Research Institute
• Original Assignee: Industrial Technology Research Institute
• Inventors: Chung, Cheng-Shiu, Tsai, Chung-Hsien, Hsieh, Wen-Pin
• Primary Examiner(s): Soohoo; Tony G
• Assistant Examiner(s): Mellon; David C
• Application Number:
  US12/060,682
• Publication Number:
  US 20090114608A1
• Time in Patent Office: 1,239 Days
• Field of Search: 210/767, 210/787, 210/512.1, 210/360.1, 422/72, 422/63, 422/64, 422/67, 422/101, 422/502, 422/506, 422/533, 422/548, 436/45
• US Class Current: 210/787
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

A fluid analytical device is provided including a body, a reservoir, an inlet channel and a separation unit. The reservoir is formed on the body. The inlet channel is formed on the body connected to the reservoir. The separation unit is formed on the body connected to the inlet channel, which includes a pile area, a collecting area and a spacer. The collecting area is located between the pile area and the reservoir. The spacer is formed between the pile area and the collecting area.

Claims

1. A fluid analytical device, comprising:

a body rotatable around an axis to generate a centrifugal force;

a reservoir, formed on the body;

an inlet channel, formed on the body connected to the reservoir;

a separation recess, formed on the body radially outward from the reservoir and connected to the inlet channel, wherein the separation recess is a single recess comprising;

a pile area;

a collecting area, radially located between the pile area and the reservoir, wherein the pile area is in line with and entirely radially outward from the collection area relative to the axis; and

a spacing wall, formed between the pile area and the collecting area, wherein the spacing wall is a protrusion protruding into the flow path of the liquid such that a top of the spacing wall is higher than a bottom surface of the pile area and collecting area, and wherein the pile area is further from the axis than the collecting area, and the inlet channel connects to the pile area at a location above the spacing wall; and

an exhaust channel connecting the collecting area and the reservoir;

wherein the reservoir, separation recess, and inlet channel are arranged such that the centrifugal force moves a liquid from the reservoir to the pile area via the inlet channel, and a first fluid constituent of the liquid remains in the pile area while a second fluid constituent of the liquid moves over the spacing wall to the collecting area due to a specific weight difference therebetween.

2. The fluid analytical device as claimed in claim 1, wherein a volume of the collecting area is smaller than a volume of the pile area.

3. The fluid analytical device as claimed in claim 1, wherein a volume ratio between the pile area and the collecting area is between 1:

1 and 2;

1.

4. The fluid analytical device as claimed in claim 1, wherein a ratio between a depth of the spacing wall and a depth of the collecting area is between ⅓

and ⅙

.

5. The fluid analytical device as claimed in claim 1, wherein the reservoir comprises a spiral groove formed on a bottom thereof.

6. The fluid analytical device as claimed in claim 1, wherein the spacer further comprises a plurality of guiding grooves formed on a top thereof.

7. The fluid analytical device as claimed in claim 1, wherein the fluid is blood, the first fluid constituent is blood cells, and the second fluid constituent is plasma.

8. A fluid analytical method for separating a first fluid constituent and a second fluid constituent, comprising:

providing the fluid analytical device as claimed in claim 1; and

rotating the fluid analytical device to separate the first and second fluid constituents, wherein the fluid analytical device is rotated with respect to the reservoir.

9. A fluid analytical device, comprising:

a body rotatable around an axis to generate a centrifugal force;

a reservoir, formed on the body;

a plurality of inlet channels, formed on the body connected to the reservoir;

a plurality of separation recesses, formed on the body radially outward from the reservoir and surrounding the reservoir, wherein each of the separation recess is connected to the inlet channel, and comprises;

a pile area;

a collecting area, radially located between the pile area and the reservoir, wherein the pile area is in line with and entirely radially outward from the collection area relative to the axis; and

a spacing wall, formed between the pile area and the collecting area, wherein the spacing wall is a protrusion protruding into the flow path of the liquid such that a top of the spacing wall is higher than a bottom surface of the pile area and collecting area, and wherein the pile area is further from the axis than the collecting area, and the inlet channel connects to the pile area at a location above the spacing wall; and

a plurality of exhaust channels respectively connecting the collecting area of each separation recess and the reservoir;

wherein the reservoir, separation recesses, and inlet channels are arranged such that the centrifugal force moves a liquid from the reservoir to the pile areas via the inlet channels, and a first fluid constituent of the liquid remains in the pile areas while a second fluid constituent of the liquid moves over the spacing walls to the collecting areas due to a specific weight difference therebetween.

10. The fluid analytical device as claimed in claim 9, wherein the separation recesses are arranged equidistantly.

11. A fluid analytical method for separating a first fluid constituent and a second fluid constituent, comprising:

providing the fluid analytical device as claimed in claim 9; and

rotating the fluid analytical device to separate the first and second fluid constituents, wherein the fluid analytical device is rotated with respect to the reservoir.