Treatment of cerebral amyloid angiopathy
First Claim
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1. A method of restoring cerebral vascular phenotype in a patient suffering from vascular Aβ
- deposits, comprising administering an antibody that is specific for Aβ
in a treatment regime associated with efficacious vascular amyloid removal, wherein the administration of the antibody restores cerebral vascular phenotype, wherein the antibody binds to an epitope within residues 1-10 of Aβ and
the antibody is administered intravenously at a quarterly frequency at a dose of 0.5-1.5 mg/kg, or monthly at a dose of 0.1-1 mg/kg, or is administered subcutaneously at a frequency between weekly and monthly at a dose of between 0.01 mg/kg to 0.35 mg/kg and the antibody is administered at least for a year.
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Abstract
The invention provides improved agents and methods for treatment of cerebral amyloid angiopathy (CAA) and methods to effect prophylaxis of CAA. The methods can treat CAA concurrently with Alzheimer'"'"'s disease or separately. The methods can effect prophylaxis of CAA concurrently with Alzheimer'"'"'s disease or separately. The methods involve administering antibody that is specific for the N-terminus of Aβ or an agent that can induce such an antibody.
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13 Claims
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1. A method of restoring cerebral vascular phenotype in a patient suffering from vascular Aβ
- deposits, comprising administering an antibody that is specific for Aβ
in a treatment regime associated with efficacious vascular amyloid removal, wherein the administration of the antibody restores cerebral vascular phenotype, wherein the antibody binds to an epitope within residues 1-10 of Aβ and
the antibody is administered intravenously at a quarterly frequency at a dose of 0.5-1.5 mg/kg, or monthly at a dose of 0.1-1 mg/kg, or is administered subcutaneously at a frequency between weekly and monthly at a dose of between 0.01 mg/kg to 0.35 mg/kg and the antibody is administered at least for a year. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- deposits, comprising administering an antibody that is specific for Aβ
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9. A method of restoring cerebral vascular meningeal vessel phenotype from structural damage from amyloid induced structural changes comprising:
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monitoring for amyloid induced structural changes involving degeneration and hyperplasia/hypertrophy of smooth muscle cells and extracellular matrix in the vessel walls, and subcutaneously or intravenously administering an antibody that is specific for Aβ
in a treatment regime associated with efficacious vascular amyloid removal, wherein the administration of the antibody restores vessels to normal phenotype;
wherein the antibody binds to an epitope within residues 1-10 of Aβ
. - View Dependent Claims (10, 11, 12, 13)
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Specification