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Chimeric immunomodulatory compounds and methods of using the same

  • US 8,003,115 B2
  • Filed: 08/10/2007
  • Issued: 08/23/2011
  • Est. Priority Date: 06/21/2001
  • Status: Active Grant
First Claim
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1. A method of modulating an immune response in an individual comprising administering to an individual a linear chimeric immunomodulatory compound (CIC) in an amount sufficient to modulate an immune response in said individual, wherein the linear CIC comprises a structure N1

  • S1

    N2

    S2

    N3,wherein N1, N2, and N3 are independently selected nucleic acid moieties comprising 3 to 7 bases, at least one of N1, N2, and N3 has the sequence 5′

    -[(X)0-2]TCG[(X)2-4]-3′

    , wherein each X is an independently selected nucleotide;

    wherein S1 is a non-nucleic acid spacer moiety covalently bound to N1 and N2;

    S2 is a non-nucleic acid spacer moiety covalently bound to N2 and N3;

    S1 and S2 are the same or different;

    each of S1 and S2 comprises hexaethylene glycol (HEG), triethyleneglycol (TEG), propyl, butyl, or hexyl; and

    wherein said CIC has at least one immunomodulatory activity selected from the group consisting of (i) the ability to stimulate interferon-gamma (IFN-γ

    ) production by human peripheral blood mononuclear cells and (ii) the ability to stimulate interferon-alpha (IFN-α

    ) production by human peripheral blood mononuclear cells.

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