Microfabricated devices and method for fabricating microfabricated devices

• US 8,004,021 B2
• Filed: 04/17/2007
• Issued: 08/23/2011
• Est. Priority Date: 04/21/2006
• Status: Active Grant

• Current Assignee: ProterixBio, Inc.
• Original Assignee: BioScale, Inc.
• Inventors: Miller, Michael F., Bakshi, Shivalik
• Primary Examiner(s): Weiss; Howard
• Assistant Examiner(s): RAO, SHRINIVAS H
• Application Number:
  US11/736,168
• Publication Number:
  US 20070284699A1
• Time in Patent Office: 1,589 Days
• Field of Search: 257/226, 257/232, 73/240.6, 73/544.1, 73/617.5, 436/283.1, 436/267.1, 438/287.2
• US Class Current: 257/226
• CPC Class Codes: B81B 2201/0214 Biosensors; Chemical sensors
• CPC Class Codes: B81B 2207/115 Protective layers applied directly to the device before packaging
• CPC Class Codes: B81B 3/0086 Electrical characteristics, e.g. reducing driving voltage, improving resistance to peak voltage
• CPC Class Codes: B81B 7/00 Microstructural systems; Auxiliary parts of microstructural devices or systems
• CPC Class Codes: B81B 7/0025 Protection against chemical alteration
• CPC Class Codes: G01N 33/5438 Electrodes

Abstract

Microfabricated devices for operation in a fluid that include a substrate that has a first and second surface and a first electrode material layer located over the first surface of the substrate. The devices have a piezoelectric material layer located over the first electrode material layer and a second electrode material layer located over the piezoelectric material layer. The devices also include a layer of isolation material located over the second electrode material layer that at least one of chemically or electrically isolates a portion of the second electrode material layer from a fluid. Some devices include a layer of conductive material located over the layer of isolation material.

Claims

1. A microfabricated device for operation in a fluid, comprising:

a substrate having a first and second surface;

a first electrode material layer located over the first surface of the substrate;

a piezoelectric material layer located over the first electrode material layer;

a second electrode material layer located over the piezoelectric material layer; and

a layer of isolation material located over the second electrode material layer that at least one of chemically or electrically isolates a portion of the second electrode material layer from a fluid.

2. The microfabricated device of claim 1, comprising a layer of conductive material located over the layer of isolation material.

3. The microfabricated device of claim 2, wherein electrical potential of the layer of conductive material is controlled to reduce the electrical interaction between the microfabricated device and the fluid or a substance in the fluid.

4. The microfabricated device of claim 1, comprising a layer of immobilization material located over the layer of isolation material to facilitate immobilization of a substance on the microfabricated device.

5. The microfabricated device of claim 1, wherein the substrate comprises a silicon layer having a first and second surface, a first silicon oxide layer adjacent the first surface of the silicon layer, a second silicon oxide layer adjacent the second surface of the silicon layer, a first silicon nitride layer adjacent the first silicon oxide layer having a surface that is the first surface of the substrate, and a second silicon nitride layer adjacent the second silicon oxide layer.

6. The microfabricated device of claim 1, wherein the second electrode material layer is a layer of metal or semiconductor material.

7. The microfabricated device of claim 5, wherein a cavity is formed in the second silicon nitride layer, the second silicon oxide layer and the silicon layer exposing the first silicon nitride layer and a portion of the silicon oxide layer between the silicon layer and the first silicon nitride layer is removed to form an undercut.

8. The microfabricated device of claim 1, wherein the isolation material is an oxide material.

9. The microfabricated device of claim 1, wherein the first or second electrode material layer comprises one or more electrodes.

10. The microfabricated device of claim 9, wherein the one or more electrodes comprise a pair of sensing electrodes and a pair of actuation electrodes.

11. The microfabricated device of claim 9, wherein the first or second electrode material layer comprises an interdigitated sensing electrode pair and an interdigitated actuation electrode pair.

12. The microfabricated device of claim 11, wherein the microfabricated device is a flexural plate wave device.

13. The microfabricated device of claim 1, comprising a layer of conductive material located over the layer of isolation material to facilitate immobilization of a substance on the microfabricated device.

14. The microfabricated device of claim 13, wherein electrical potential of the layer of conductive material is controlled to reduce the electrical interaction between the microfabricated device and the fluid or a substance in the fluid.

15. The microfabricated device of claim 3, wherein the substance is selected from the group consisting of whole cells, bacteria, yeast, fungi, blood cells, dissociated tissue cells, spores, viruses, proteins, antibodies, lipids, carbohydrates, nucleic acids, peptides and small molecules.

16. The microfabricated device of claim 2, wherein the layer of conductive material is a barrier between the layer of isolation material and the fluid.

17. The microfabricated device of claim 1, comprising a fluid channel over the layer of isolation material to deliver the fluid to a surface of the layer of isolation material.

18. The microfabricated device of claim 17, wherein a signal output by the first and second electrode material layers is representative of the propagation characteristics of a structure incorporates the piezoelectric material layer.

19. A microfabricated device for operation in a fluid, comprising:

a substrate having a first and second surface;

a first electrode material layer located over the first surface of the substrate;

a piezoelectric material layer located over the first electrode material layer;

a second electrode material layer located over the piezoelectric material layer; and

a layer of isolation material located over the second electrode material layer that at least one of chemically or electrically isolates a portion of the second electrode material layer from a fluid,

wherein the first or second electrode material layer comprises a pair of sensing electrodes and a pair of actuation electrodes.