Endocardial pacing devices and methods useful for resynchronization and defibrillation

• US 8,005,544 B2
• Filed: 06/26/2008
• Issued: 08/23/2011
• Est. Priority Date: 12/20/2004
• Status: Active Grant

• Current Assignee: Newstim, Inc.
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhu, Qingsheng, Ortega, Daniel Felipe
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US12/147,425
• Publication Number:
  US 20080319496A1
• Time in Patent Office: 1,153 Days
• Field of Search: 607/2, 607/4, 607/5, 607/9, 607/25
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Various methods and apparatus are implemented for modifying cardiac operation, for treating a condition of a patient'"'"'s heart, and for monitoring cardiac operation. An electrode arrangement is used to capture the myocardium for re-synchronization of the left and right ventricles by providing first and second signal components having opposite polarity on respective electrodes. Use of a defibrillation lead may also be particularly useful. Other aspects involve use of such cardiac modulation technique to facilitate mechanically and/or electrically synchronous contractions for resynchronization, and a technique for pacing and/or mapping by generating pulses for delivery to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof.

Claims

1. For use in a myocardium capture by delivering pacing signals via electrodes to a target region in the right ventricle, at or near the septum of a heart and at or near a bundle of His and at or near the right ventricular outflow tract and distal from an apex of the right ventricle, a circuit arrangement comprising:

first and second conductors, configured to be respectively coupled to the electrodes, for providing pacing signals of opposing polarity to the target region at or near the septum of the heart and at or near the bundle of His, and a third conductor configured for providing a defibrillation signal to the right ventricle apex; and

a control module configured for generating the pacing signals, with two pulses occurring sufficiently proximate one another in at least one of time or distance for the myocardium capture near the target region at or near the septum of the heart and at or near the bundle of His, on the first and second conductors and for generating the defibrillation signal.

2. The circuit arrangement of claim 1, wherein the two pulses occur sufficiently proximate one another for a single myocardium capture.

3. The circuit arrangement of claim 1, further including another conductor, and wherein control module is adapted to pace and sense the atrium via the other conductor.

4. The circuit arrangement of claim 1, wherein control module is adapted to deliver defibrillation therapy from the right side of the heart.

5. The circuit arrangement of claim 1, wherein the control module is an IPG and wherein the leads are individually-addressable by the IPG.

7. The circuit arrangement of claim 1, wherein the control module is configured for generating the pacing signals, with two pulses occurring sufficiently proximate one another in time for the myocardium capture near the target region at or near the septum of the heart and at or near the bundle of His.

8. The circuit arrangement of claim 1, wherein the control module is configured for generating the pacing signals, with two pulses occurring sufficiently proximate one another in distance for the myocardium capture near the target region at or near the septum of the heart and at or near the bundle of His.

9. The circuit arrangement of claim 1, wherein the control module is configured for delivering at least partially concurrent opposite polarity pulses at the target region.

6. For treatment of a heart by way of a myocardium capture, a method comprising:

providing a control module capable of delivering

on first and second conductors, pacing signals of opposing polarity to the target region in the right ventricle, near the septum of a heart and distal from an apex of the right ventricle, and

on a third conductor, a defibrillation signal to the right ventricle apex; and

for fibrillation condition of the heart, delivering the defibrillation signal on the third conductor;

delivering the pacing signals on the first and second conductors; and

using the pacing signals to pace the right ventricle and the left ventricle of the heart for synchronous contraction of the right and left ventricles using at least the first electrode at the location in the right ventricle, and wherein the pacing signals are delivered to improve a QRS width of the patient, a fractionation of the patient and a timing of electrical stimulation of a late activation site of the left ventricle relative to the QRS.

10. The method of claim 6, including delivering at least partially concurrent opposite polarity pulses at the target region.

11. The method of claim 6, comprising delivering the pacing signals to improve a QRS width of the patient.

12. The method of claim 6, comprising delivering the pacing signals to improve a fractionation of the patient.

13. The method of claim 6, comprising delivering the pacing signals to improve a timing of electrical stimulation of a late activation site of the left ventricle relative to the QRS.