Medical devices and techniques for rodent and small mammalian based research
First Claim
1. An external small mammal pulse oximetry system comprising:
- A) an emitter adjacent a small mammal, the emitter having two light sources of distinct wavelengths;
B) a receiver adjacent the small mammal for detecting light from the emitter that has been transmitted toward a perfused tissue of the small mammal; and
C) a controller to control the emitter and process signals from the receiver, wherein the controller is configured to receive a first and a second digital signal from the receiver associated with one distinct wavelength of light and to receive a first and a second digital signal from the receiver associated with the other distinct wavelength of light, and wherein the digital signals are utilized to determine the pulse rate of the small mammal and the blood oxygenation level of the small mammal, wherein the controller is configured to determine heart rate pulses of at least 450 beats per minute.
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Abstract
A method and system of supplying rodents, such as mice, to medical researchers pre-installs and/or embeds physiologic sensors onto or within the rodents prior to selling the modified rodents to the researchers. The specialty skills, such as small animal surgical and anesthesia skills and sensor placement and testing, are centralized in one organization rather than being spread about a collection of researchers. The subjects with preinstalled, pre-tested hardware, are sold to the researcher as needed. Communication hardware and software will be supplied for the user to convert their desktop computer into a wireless monitoring station. Additionally an external pulse oximeter for small rodents, such as mice, provides measurements on a hand or foot of the rodent with a sensor configured to avoid shunting around the rodent appendage, and configured for high heart rates (200-900 beats per minutes) of the subjects.
66 Citations
18 Claims
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1. An external small mammal pulse oximetry system comprising:
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A) an emitter adjacent a small mammal, the emitter having two light sources of distinct wavelengths; B) a receiver adjacent the small mammal for detecting light from the emitter that has been transmitted toward a perfused tissue of the small mammal; and C) a controller to control the emitter and process signals from the receiver, wherein the controller is configured to receive a first and a second digital signal from the receiver associated with one distinct wavelength of light and to receive a first and a second digital signal from the receiver associated with the other distinct wavelength of light, and wherein the digital signals are utilized to determine the pulse rate of the small mammal and the blood oxygenation level of the small mammal, wherein the controller is configured to determine heart rate pulses of at least 450 beats per minute. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An external small mammal pulse detecting system comprising:
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A) an emitter adjacent the small mammal, the emitter having two light sources of distinct wavelengths; B) a receiver adjacent the small mammal for detecting light from the emitter that has been transmitted toward a perfused tissue of the small mammal; and C) a controller to control the emitter and process signals from the receiver, wherein the controller is configured to determine the pulse rates of the small mammal using the processed signals from the receiver, wherein the pulse rates are at least 450 beats per minute. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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Specification