Sensing rate of change of pressure in the left ventricle with an implanted device

• US 8,007,442 B2
• Filed: 02/10/2010
• Issued: 08/30/2011
• Est. Priority Date: 06/01/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Wariar, Ramesh, Carlson, Gerrard M., Siejko, Krzysztof Z., Brockway, Marina V.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): MORALES, JON ERIC C
• Application Number:
  US12/703,533
• Publication Number:
  US 20100145403A1
• Time in Patent Office: 566 Days
• Field of Search: 600/528, 600/513, 600/508, 600/586, 600/587, 600/481, 600/483, 600/485, 600/486, 600/488
• US Class Current: 600/528
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 7/00 Instruments for auscultation
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/375 Constructional arrangements, e.g. casings
• CPC Class Codes: A61N 1/37512 Pacemakers

Abstract

An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.

Claims

1. A device comprising:

a transducer configured to convert an acceleration correlative to a S1 heart sound into an electrical signal;

a control circuit coupled to the transducer, the control circuit configured to receive the electrical signal, identify the acceleration correlative to the S1 heart sound, determine a maximum amplitude of the acceleration correlative to the S1 heart sound and a minimum amplitude of the acceleration correlative to the S1 heart sound, and determine a patient status indicator using an indication of a peak-to-peak difference between the maximum amplitude of the acceleration correlative to the S1 heart sound and the minimum amplitude of the acceleration correlative to the S1 heart sound, wherein the patient status indicator is correlative to at least one of contractility or a maximum time rate of change of pressure within a ventricle of a heart during a cardiac cycle, wherein the control circuit is configured to use an auxiliary physiological signal to select the accelerations used in the determination of the patient status indicator, the auxiliary physiological signal indicative of at least one of physical activity or respiration.

2. The device of claim 1, wherein the device is configured to detect the auxiliary physiological signal in conjunction with detection of the acceleration correlative to the S1 heart sound;

determine an auxiliary indicator using a characteristic of the auxiliary physiological signal; and

wherein the control circuit is configured to use the auxiliary indicator in determining the patient status indicator; and

provide the patient status indicator for a user or automated process.

3. The device of claim 1, wherein the auxiliary physiological signal includes a motion-related acceleration.

4. The device of claim 1, wherein the control circuit is configured to determine the peak-to-peak difference between the maximum amplitude of the acceleration correlative to the S1 heart sound and a minimum amplitude of the acceleration correlative to the S1 heart sound by:

identifying a time, t_m, associated with a beginning of the acceleration correlative to the S1 heart sound, and a time, t_n, associated with an ending of the acceleration correlative to the S1 heart sound;

identifying, during a span of time between t_m and t_n, a global maximum amplitude of the acceleration correlative to the S1 heart sound and a global minimum amplitude of the acceleration correlative to the S1 heart sound;

determining, for a plurality of accelerations correlative to respective S1 heart sounds, a central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds and a central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds; and

subtracting the central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds from the central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds to determine the peak-to-peak difference.

5. The device of claim 1, wherein the device is configured to mate to a lead system that is configured to extend from the device to a patient'"'"'s heart.

6. The device of claim 1, wherein the transducer comprises an accelerometer.

7. The device of claim 1, further comprising:

a therapy delivery circuit coupled to the control circuit, the therapy delivery circuit configured to deliver therapy to a heart in the form of electrical impulses.

8. The device of claim 7, wherein the control circuit is further configured to adjust the therapy delivered by the therapy deliver circuit using the patient status indicator.

9. A method comprising:

using a transducer to detect an acceleration correlative to an S1 heart sound;

converting the acceleration correlative to S1 heart sound into an electrical signal using the transducer;

using the electrical signal to determine a maximum amplitude of the acceleration correlative to the S1 heart sound and a minimum amplitude of the acceleration correlative to the S1 heart sound; and

determining a patient status indicator using an indication of a peak-to-peak difference between the maximum amplitude of the acceleration correlative to the S1 heart sound and the minimum amplitude of the acceleration correlative to the S1 heart sound, wherein the patient status indicator is correlative to at least one of contractility or a maximum time rate of change of pressure within a ventricle of a heart during a cardiac cycle, wherein an auxiliary physiological signal is used to select the accelerations used in the determination of the patient status indicator, the auxiliary physiological signal indicative of at least one of physical activity or respiration.

10. The method of claim 9, comprising:

detecting the auxiliary physiological signal in conjunction with detection of the acceleration correlative to the S1 heart sound;

determining an auxiliary indicator using a characteristic of the auxiliary physiological signal;

using the auxiliary indicator in determining the patient status indicator; and

providing the patient status indicator for a user or automated process.

11. The method of claim 9, wherein the auxiliary physiological signal includes a motion-related acceleration.

12. The method of claim 9, comprising determining the peak-to-peak difference between the maximum amplitude of the acceleration correlative to the S1 heart sound and the minimum amplitude of the acceleration correlative to the S1 heart sound by:

identifying a time, t_m, associated with a beginning of the acceleration correlative to the S1 heart sound, and a time, t_n, associated with an ending of the acceleration correlative to the S1 heart sound;

identifying, during a span of time between t_m and t_n, a global maximum amplitude of the acceleration correlative to the S1 heart sound and a global minimum amplitude of the acceleration correlative to the S1 heart sound;

determining, for a plurality of accelerations correlative to respective S1 heart sounds, a central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds and a central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds; and

subtracting the central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds from the central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds to determine the peak-to-peak difference.

13. The method of claim 9, further comprising:

storing the maximum amplitude of the acceleration correlative to the S1 heart sound and the minimum amplitude of the acceleration correlative to the S1 heart sound in a datastore, so that a trend regarding the maximum amplitude and the minimum amplitude may be obtained.

14. The method of claim 9, further comprising:

adjusting a therapy delivered to said heart using the patient status indicator.

15. The method of claim 14, wherein the therapy comprises cardiac resynchronization therapy.

16. The method of claim 9, further comprising:

adjusting a drug dosage using the patient status indicator.

17. The method of claim 9, further comprising:

transmitting the patient status indicator to an external unit for display.

18. A non-transitory device-readable medium including instructions that, when performed by the device, comprise:

using a transducer to detect an acceleration correlative to an S1 heart sound;

converting the acceleration correlative to S1 heart sound into an electrical signal using the transducer;

using the electrical signal to determine a maximum amplitude of the acceleration correlative to the S1 heart sound and a minimum amplitude of the acceleration correlative to the S1 heart sound; and

determining a patient status indicator using an indication of a peak-to-peak difference between the maximum amplitude of the acceleration correlative to the S1 heart sound and the minimum amplitude of the acceleration correlative to the S1 heart sound, wherein the patient status indicator is correlative to at least one of contractility or a maximum time rate of change of pressure within a ventricle of a heart during a cardiac cycle, wherein an auxiliary physiological signal is used to select the accelerations used in the determination of the patient status indicator, the auxiliary physiological signal indicative of at least one of physical activity or respiration.

19. The non-transitory device-readable medium of claim 18, comprising detecting the auxiliary physiological signal in conjunction with detection of the acceleration correlative to the S1 heart sound;

determining an auxiliary indicator using a characteristic of the auxiliary physiological signal;

using the auxiliary indicator in determining the patient status indicator; and

providing the patient status indicator for a user or automated process.

20. The non-transitory device-readable medium of claim 18, comprising determining the peak-to-peak difference between the maximum amplitude of the acceleration correlative to the S1 heart sound and the minimum amplitude of the acceleration correlative to the S1 heart sound by:

identifying a time, t_m, associated with a beginning of the acceleration correlative to the S1 heart sound, and a time, t_n, associated with an ending of the acceleration correlative to the S1 heart sound;

identifying, during a span of time between t_m and t_n, a global maximum amplitude of the acceleration correlative to the S1 heart sound and a global minimum amplitude of the acceleration correlative to the S1 heart sound;

determining, for a plurality of accelerations correlative to respective S1 heart sounds, a central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds and a central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds; and

subtracting the central tendency of the global minimum amplitudes correlative to the respective S1 heart sounds from the central tendency of the global maximum amplitudes correlative to the respective S1 heart sounds to determine the peak-to-peak difference.