Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same

• US 8,007,775 B2
• Filed: 12/30/2004
• Issued: 08/30/2011
• Est. Priority Date: 12/30/2004
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Hossainy, Syed F.A., Pacetti, Stephen D.
• Primary Examiner(s): Hartley; Michael G
• Assistant Examiner(s): Rogers; James
• Application Number:
  US11/027,955
• Publication Number:
  US 20060147412A1
• Time in Patent Office: 2,434 Days
• Field of Search: 424/78.37, 424/78.31
• US Class Current: 424/78.37
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: C08B 37/0072 Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
• CPC Class Codes: C08B 37/0075 Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
• CPC Class Codes: C08G 63/06 derived from hydroxycarboxylic acids
• CPC Class Codes: C08G 63/664 derived from hydroxy carboxylic acids
• CPC Class Codes: C08G 63/912 derived from hydroxycarboxylic acids
• CPC Class Codes: C08L 1/08 Cellulose derivatives
• CPC Class Codes: C08L 1/286 substituted with acid radicals, e.g. carboxymethyl cellulose [CMC] C08L1/282 takes precedence
• CPC Class Codes: C08L 25/18 Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
• CPC Class Codes: C08L 2666/04 Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
• CPC Class Codes: C08L 2666/06 Homopolymers or copolymers of unsaturated hydrocarbons; Derivatives thereof
• CPC Class Codes: C08L 2666/20 Macromolecular compounds having nitrogen in the main chain according to C08L75/00 - C08L79/00; Derivatives thereof
• CPC Class Codes: C08L 2666/22 Macromolecular compounds not provided for in C08L2666/16 - C08L2666/20
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 33/26 Homopolymers or copolymers of acrylamide or methacrylamide
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 5/02 Dextran; Derivatives thereof
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C08L 5/10 Heparin; Derivatives thereof
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides
• CPC Class Codes: C08L 77/12 : Polyester-amides
• CPC Class Codes: C09D 101/286 : substituted with acid radicals C09D101/282 takes precedence
• CPC Class Codes: C09D 105/02 : Dextran; Derivatives thereof
• CPC Class Codes: C09D 105/08 : Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C09D 105/10 : Heparin; Derivatives thereof
• CPC Class Codes: C09D 167/04 : Polyesters derived from hydroxycarboxylic acids, e.g. lactones C09D167/06 takes precedence

Abstract

Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a poly(hydroxyalkanoate).

Claims

1. A composition comprising a polymer represented by a formula:

2. The composition of claim 1, wherein the polysaccharide comprises a component selected from a group consisting of carboxymethylcellulose, sulfonated dextran, sulfated dextran, dermatan sulfate, chondroitin sulfate, hyaluronic acid, heparin, hirudin, and any derivatives, analogs, homologues, congeners, salts, copolymers and combinations thereof.

3. The composition of claim 1, wherein the agent comprises a component selected from a group consisting of a free radical scavenger, a nitric oxide donor, rapamycin, methyl rapamycin, everolimus, 42-Epi-(tetrazoylyl)rapamycin (ABT-578), tacrolimus, paclitaxel, docetaxel, estradiol, clobetasol, idoxifen, tazarotene and any prodrugs, metabolites, analogs, homologues, congeners, and any derivatives, salts and combinations thereof.

4. The composition of claim 3, wherein the free radical scavenger comprises a component selected from a group consisting of 2,2′

,6,6′

-tetramethyl-1-piperinyloxy, free radical;

4-amino-2,2′

,6,6′

-tetramethyl-1-piperinyloxy, free radical;

4-hydroxy-2,2′

,6,6′

-tetramethyl-piperidene-1-oxy, free radical;

2,2′

,3,4,5,5′

-hexamethyl-3-imidazolinium-1-yloxy methyl sulfate, free radical;

16-doxyl-stearic acid, free radical;

superoxide dismutase mimic; and

, any analogs, homologues, congeners, derivatives, salts and combinations thereof.

5. The composition of claim 3, wherein the free radical scavenger comprises a component selected from a group consisting of TEMPO and any analogs, homologues, congeners, derivatives, salts or combinations thereof.

6. The composition of claim 3, wherein the nitric oxide donor comprises a component selected from the group consisting of S-nitrosothiols, nitrites, N-oxo-N-nitrosamines, substrates of nitric oxide synthase, diazenium diolates and any analogs, homologues, congeners, derivatives, salts and combinations thereof.

7. The composition of claim 1 further comprising an additional agent that is combined with the composition.

8. The composition of claim 7, wherein the additional agent comprises an essential oil.

9. The composition of claim 8, wherein the essential oil comprises garlic oil.

10. The composition of claim 7, wherein the additional agent comprises a component selected from a group consisting of castor oil, fish oil, ethanol, xylene, dimethyl formamide, glycerol, and combinations thereof.

11. The composition of claim 1, wherein L₁ or L₂ comprises a component selected from a group consisting of amides, esters, anhydrides, orthoesters, all-aromatic carbonates, and combinations thereof.