Mixed amino acid/mineral compounds having improved solubility

• US 8,007,846 B2
• Filed: 01/16/2007
• Issued: 08/30/2011
• Est. Priority Date: 01/18/2006
• Status: Active Grant

• Current Assignee: Albion Laboratories Incorporated (Balchem Corporation)
• Original Assignee: Albion International Incorporated (Balchem Corporation)
• Inventors: Ashmead, Stephen, Ericson, Clayton, Bortz, Jonathan, Thompson, R. Charles
• Primary Examiner(s): Heggestad; Helen F
• Application Number:
  US11/623,476
• Publication Number:
  US 20070172551A1
• Time in Patent Office: 1,687 Days
• Field of Search: 426/74, 426/656
• US Class Current: 426/74
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/165 Complexes or chelates
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/044 Malic acid
• CPC Class Codes: A23V 2250/061 Aspartic acid
• CPC Class Codes: A23V 2250/0622 Glycine
• CPC Class Codes: A23V 2250/1592 Iron
• CPC Class Codes: A23V 2250/1628 Silicium

Abstract

Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.

Claims

1. A composition comprising:

a metal chelate consisting essentially of;

a iron(II);

a glycine chelated to the iron(II); and

an aspartic acid chelated to the iron(II), wherein the metal chelate has a solubility from about 2.25 M to about 5 M;

a malic acid or salt thereof in an amount of from about 7% to about 8% by weight of the composition to improve solubility of the metal chelate in water;

a succinic acid or salt thereof in an amount of from about 7% to about 10% by weight of the composition to improve intestinal absorption of the metal chelate; and

with the metal chelate in an amount of from about 77% to about 84.5% by weight of the composition.

2. A composition as in claim 1, wherein the composition comprises:

succinic acid or salt thereof in an amount of about 10% by weight of the composition;

malic acid or salt thereof in an amount of about 7% by weight of the composition; and

the chelate in an amount of about 77% by weight of the composition.

3. A composition as in claim 1, wherein the composition comprises:

succinic acid or salt thereof in an amount of about 8% by weight of the composition;

malic acid or salt thereof in an amount of about 7% by weight of the composition; and

the chelate in an amount of about 84% by weight of the composition.

4. A composition as in claim 1, wherein the composition comprises:

succinic acid or salt thereof in an amount of about 7% by weight of the composition;

malic acid or salt thereof in an amount of about 8% by weight of the composition;

glycine in an amount of about 48% by weight of the composition;

aspartic acid in an amount of about 15% by weight of the composition; and

the iron atom in an amount of about 21% by weight of the composition.

5. A composition as in claim 1, wherein the composition comprises:

fumed silica in an amount of about 0.5% by weight of the composition;

succinic acid or salt thereof in an amount of about 7% by weight of the composition;

malic acid or salt thereof in an amount of about 8% by weight of the composition;

glycine in an amount of about 48% by weight of the composition;

aspartic acid in an amount of about 15% by weight of the composition; and

the iron atom in an amount of about 21% by weight of the composition.

6. A chelate as in claim 1, wherein the chelate has a solubility of about 2.5 M.