Valve analytical system

• US 8,008,080 B2
• Filed: 09/23/2009
• Issued: 08/30/2011
• Est. Priority Date: 09/23/2009
• Status: Active Grant

• Current Assignee: Ecolab, Inc., Ecolab USA Incorporated (Ecolab, Inc.)
• Original Assignee: Ecolab USA Incorporated (Ecolab, Inc.)
• Inventors: Christensen, William, Tokhtuev, Eugene, Owen, Christopher
• Primary Examiner(s): Nagpaul; Jyoti
• Application Number:
  US12/565,520
• Publication Number:
  US 20110070654A1
• Time in Patent Office: 706 Days
• Field of Search: 422 99-100, 422 63- 65, 436/45, 436/180, 251/142
• US Class Current: 436/45
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: G01N 35/1097 characterised by the valves valves in general F16K
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/111666 Utilizing a centrifuge or compartmented rotor
• CPC Class Codes: Y10T 436/15 Inorganic acid or base [e.g. , hcl, sulfuric acid, etc. ]
• CPC Class Codes: Y10T 436/201666 Carboxylic acid
• CPC Class Codes: Y10T 436/206664 Ozone or peroxide
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A lab on a valve analytical system includes a rotary sample preparation assembly having a stator and a rotor. The rotor includes a plurality of integral syringe pumps which can be aligned with passages formed within the stator. The stator passages can be connected with fluid inlet connector which connect the sample preparation assembly with fluid sources, and fluid outlet connectors which connect the sample preparation assembly with one or more wet chemical analytical devices. Some embodiments can include a mixer and optical sensor connected with the fluid outlets. One or more drive motors can be used to control simultaneous actuation of one or more of the syringe pumps, thereby providing for simultaneous delivery of metered volumes of fluid.

Claims

1. A rotary valve analytical system comprising:

a rotor having a rotor face, the rotor being rotatable about an axis perpendicular to the rotor face, wherein the rotor face has a plurality of openings, each of which is disposed at a selected radial distance from the axis, and wherein the openings extend into the rotor to form syringe barrels;

a stator disposed coaxially with the rotor, the stator having a stator face in sealable, slidable rotary contact with the rotor face, wherein the stator face has a plurality of sets of openings each set of openings comprising a plurality of openings disposed at a common radial distance from the axis and each set of openings having common angular distances separating the plurality of openings therein, wherein the common radial distance of each set of openings in the stator face equals one or more of the selected radial distances of the openings in the rotor face, and wherein each opening extends as a passage through the stator to an outlet port;

a plurality of plungers, one of said plungers disposed within each of the syringe barrels of the rotor;

a syringe drive motor, mechanically coupled with the plungers and adapted to drive and withdraw the plungers within the syringe barrels;

a rotor drive motor mechanically coupled with the rotor and adapted to cause the rotor to rotate relative to the stator;

a plurality of inlet tubes, each inlet tube coupled with one of the outlet ports of the stator and adapted to deliver a fluid to the system;

a plurality of outlet tubes, each outlet tube coupled with one of the outlet ports of the stator, wherein at least one opening of each set of openings of the stator is coupled with one of the outlet tubes and at least one opening of each set of openings of the stator is coupled with one of the inlet tubes;

a mixer in fluid communication with each of the outlet tubes and adapted to mix fluid that enters the mixer from the outlet tubes;

a sensor in fluid communication with the mixer, adapted to perform a measurement on the mixed fluids.

2. The rotary valve analytical system of claim 1, wherein the sensor comprises an optical sensor, the measurement comprising the measurement of one or more optical characteristics of the mixed fluids.

3. The rotary valve analytical system of claim 2, wherein the one or more measured optical characteristics of the mixed fluids are selected from the group comprising transmittance, absorbance, fluorescence, and time or temperature derivatives thereof.

4. The rotary valve analytical system of claim 3, wherein the one or more measured optical characteristics comprise absorbance and time derivative of absorbance.

5. The rotary valve analytical system of claim 1, wherein the plurality of inlet tubes comprise a sample inlet tube, coupled with a source of sample, a reagent tube coupled with a source of reagent, and an acid inlet tube coupled with a source of acid.

6. The rotary valve analytical system of claim 5, further comprising a diluent inlet tube coupled with a source of a diluent.

7. The rotary valve analytical system of claim 5, wherein the sample comprises a use composition comprising a peracid and a peroxide, the reagent comprises potassium iodide, and the acid comprises acetic acid.