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Methods of treating cancer using immunostimulatory oligonucleotides

  • US 8,008,266 B2
  • Filed: 11/21/2003
  • Issued: 08/30/2011
  • Est. Priority Date: 07/15/1994
  • Status: Expired due to Fees
First Claim
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1. A method for treating cancer, comprising:

  • administering to a human subject an effective amount for treating cancer of a CpG immunostimulatory oligonucleotide having at least one unmethylated CpG dinucleotide, wherein at least one nucleotide of the stabilized CpG immunostimulatory oligonucleotide has a phosphate backbone modification and wherein the oligonucleotide is 8 to 100 nucleotides in length, wherein the phosphate backbone modification is a phosphorothioate modification, further comprising administering an antigen.

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