Antiviral oligonucleotides
First Claim
1. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the herpesviridae.
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Accused Products
Abstract
Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length. Also described are methods for the prophylaxis or treatment of a viral infection in a human or animal, and a method for the prophylaxis treatment of cancer caused by oncoviruses in a human or animal. The methods typically involve administering to a human or animal in need of such treatment, a pharmacologically acceptable, therapeutically effective amount of at least oligonucleotide that does not act by a sequence complementary mode of action.
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Citations
45 Claims
- 1. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the herpesviridae.
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2. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets HSV-1.
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3. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets HSV-2.
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4. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets cytomegalovirus.
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5. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the hepadnaviridae.
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6. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets hepatitis B virus.
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7. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the poxviridae.
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8. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the paramyxoviridae.
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9. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets respiratory syncytial virus.
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10. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets parainfluenza virus.
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11. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the bunyaviridae.
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12. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets hantavirus.
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13. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the filoviridae.
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14. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets Ebola virus.
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15. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets Marburg virus.
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16. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the flaviviridae.
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17. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets yellow fever virus, dengue virus or West Nile virus.
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18. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets hepatitis C virus.
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19. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the orthomyxoviridae.
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20. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets influenza virus.
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21. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets influenza A virus.
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22. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets influenza B virus.
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23. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the togaviridae.
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24. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the coronaviridae.
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25. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the rhabdoviridae.
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26. An antiviral oligonucleotide formulation comprising at least one fully phosphorothioated antiviral oligonucleotide, wherein said oligonucleotide is between 20 and 120 nucleotides in length, wherein the antiviral activity of said oligonucleotide occurs by a non-sequence dependent mode of action, wherein said oligonucleotide targets a member of the arenaviridae.
Specification