Methods and compositions for the treatment of neuropsychiatric disorders
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Abstract
The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are effective in reducing the effective amount, inactivating, and/or inhibiting the activity of a Na+—K+-2Cl− (NKCC) cotransporter. In certain embodiments, the Na+—K+-2Cl− co-transporter is NKCC1.
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Citations
5 Claims
- 1. A compound of formula I:
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5. A compound which is bumetanide benzyl ester, bumetanide morpholinoethyl ester;
- bumetanide 3-(dimethylaminopropyl) ester;
bumetanide N,N-diethylglycolamide ester;
bumetanide dimethylglycolamide ester;
bumetanide pivaxetil ester;
bumetanide propaxetil ester, or pharmaceutically acceptable salts or tautomers thereof.
- bumetanide 3-(dimethylaminopropyl) ester;
Specification