×

Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics

  • US 8,008,449 B2
  • Filed: 05/02/2006
  • Issued: 08/30/2011
  • Est. Priority Date: 05/09/2005
  • Status: Active Grant
First Claim
Patent Images

1. An isolated human monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody or antigen-binding portion thereof cross-competes for binding to PD-1 with a reference antibody or reference antigen-binding portion thereof comprising:

  • a) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    1 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    8;

    b) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    2 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    9;

    c) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    3 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    10;

    d) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    4 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    11;

    e) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    5 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    12;

    f) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    6 and a human light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    13;

    org) a human heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    7 and a human light chain variable region comprising amino acids having the sequence set forth in SEO ID NO;

    14.

View all claims
  • 7 Assignments
Timeline View
Assignment View
    ×
    ×