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Catalysts for body fluid sample extraction

  • US 8,012,103 B2
  • Filed: 09/29/2006
  • Issued: 09/06/2011
  • Est. Priority Date: 09/30/2005
  • Status: Active Grant
First Claim
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1. An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site, and for calculating the presence and/or concentration of a target analyte, the arrangement comprising:

  • a plurality of skin-penetration members each having a first end configured to pierce the surface of the skin, and each skin-penetration member further comprising an inner lumen in communication with each first end;

    a plurality of torsional spring actuators, each actuator operatively associated with a respective skin-penetration member; and

    at least one catalyst device configured to facilitate perfusion of body fluid at the sampling site;

    wherein each spring actuator has a neutral rest position, and wherein each spring actuator is constructed and positioned such that in use the first end of each skin-penetration member obstructs the wound opening when a respective spring actuator is in the neutral rest position, and wherein each skin-penetration member is urged along an arcuate path by a respective spring actuator;

    a plurality of signaling mechanisms, each signaling mechanism associated with a respective skin penetration member, each signaling mechanism constructed to generate a detectable signal indicative of the presence and/or concentration of the target analyte;

    at least one detector associated with the plurality of signaling mechanisms, the at least one detector constructed to detect the detectable signal generated by each signaling mechanism; and

    electronics configured to calculate the presence and/or concentration of the target analyte using a signal transmitted by the at least one detector;

    wherein the arrangement is configured to retract the skin-penetration member after the calculation of the presence and/or concentration of the target analyte by the electronics.

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