Catalysts for body fluid sample extraction
First Claim
1. An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site, and for calculating the presence and/or concentration of a target analyte, the arrangement comprising:
- a plurality of skin-penetration members each having a first end configured to pierce the surface of the skin, and each skin-penetration member further comprising an inner lumen in communication with each first end;
a plurality of torsional spring actuators, each actuator operatively associated with a respective skin-penetration member; and
at least one catalyst device configured to facilitate perfusion of body fluid at the sampling site;
wherein each spring actuator has a neutral rest position, and wherein each spring actuator is constructed and positioned such that in use the first end of each skin-penetration member obstructs the wound opening when a respective spring actuator is in the neutral rest position, and wherein each skin-penetration member is urged along an arcuate path by a respective spring actuator;
a plurality of signaling mechanisms, each signaling mechanism associated with a respective skin penetration member, each signaling mechanism constructed to generate a detectable signal indicative of the presence and/or concentration of the target analyte;
at least one detector associated with the plurality of signaling mechanisms, the at least one detector constructed to detect the detectable signal generated by each signaling mechanism; and
electronics configured to calculate the presence and/or concentration of the target analyte using a signal transmitted by the at least one detector;
wherein the arrangement is configured to retract the skin-penetration member after the calculation of the presence and/or concentration of the target analyte by the electronics.
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Accused Products
Abstract
An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.
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Citations
23 Claims
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1. An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site, and for calculating the presence and/or concentration of a target analyte, the arrangement comprising:
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a plurality of skin-penetration members each having a first end configured to pierce the surface of the skin, and each skin-penetration member further comprising an inner lumen in communication with each first end; a plurality of torsional spring actuators, each actuator operatively associated with a respective skin-penetration member; and at least one catalyst device configured to facilitate perfusion of body fluid at the sampling site; wherein each spring actuator has a neutral rest position, and wherein each spring actuator is constructed and positioned such that in use the first end of each skin-penetration member obstructs the wound opening when a respective spring actuator is in the neutral rest position, and wherein each skin-penetration member is urged along an arcuate path by a respective spring actuator; a plurality of signaling mechanisms, each signaling mechanism associated with a respective skin penetration member, each signaling mechanism constructed to generate a detectable signal indicative of the presence and/or concentration of the target analyte; at least one detector associated with the plurality of signaling mechanisms, the at least one detector constructed to detect the detectable signal generated by each signaling mechanism; and electronics configured to calculate the presence and/or concentration of the target analyte using a signal transmitted by the at least one detector; wherein the arrangement is configured to retract the skin-penetration member after the calculation of the presence and/or concentration of the target analyte by the electronics. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification