Extractable dose setting knob

• US 8,012,131 B2
• Filed: 01/16/2007
• Issued: 09/06/2011
• Est. Priority Date: 01/17/2006
• Status: Active Grant

• Current Assignee: Ypsomed AG (Ypsomed Holding AG)
• Original Assignee: TecPharma Licensing AG (Ypsomed Holding AG)
• Inventors: Moser, Ulrich, Hirschel, Juerg, Schrul, Christian
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): Patel; Shefali D
• Application Number:
  US11/623,533
• Publication Number:
  US 20080071226A1
• Time in Patent Office: 1,694 Days
• Field of Search: 604/110, 604/181, 604/187, 604/207, 604/208, 604/209, 604/210, 604/211, 604/218, 604/224, 604/228, 604/500, 604/506
• US Class Current: 604/208
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31555 by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/502 for blocking the piston

Abstract

An injection device for dispensing a dose of a substance, the device including a housing, a dispensing element which can be displaced relative to the housing and a locking element which can be coupled with the dispensing element during or after a substance dispensing operation so that after the dispensing element has effected a dispensing operation once, it can no longer be operated to dispense another dose, and a method of locking an injection device after a substance has been dispensed once, whereby a dispensing element operated to dispense the substance is locked or blocked before, during or after dispensing a set dose so that no more substance can be dispensed.

Claims

1. An injection device for setting and dispensing a dose of a substance, the device comprising:

a housing;

a guide sleeve arranged in the housing, the guide sleeve comprising one or more lugs;

a dispensing element which can be displaced relative to the housing by a user pulling the dispensing element out of the housing or the user pushing the dispensing element into the housing, the dispensing element comprising at least one catch orifice; and

a toothed rack arranged in the housing and guided by the guide sleeve, the toothed rack displaceable relative to the housing and the guide sleeve and comprising an end configured to engage with a stopper, a plurality of teeth disposed at a middle portion of the toothed rack and a locking element arranged at an end opposite the end configured to engage with the stopper, wherein the plurality of teeth are configured to engage with the one or more lugs to allow the toothed rack to move in a dispensing direction but not in a direction opposite the dispensing direction, and the locking element is configured to establish a coupling engagement with the at least one catch orifice before or during a substance dispensing operation and at least after the substance dispensing operation, and is further configured to remain substantially unengaged with the catch orifice until after a dose setting operation is complete;

whereby, due to an engagement between the at least one or more lugs and the teeth and the coupling engagement between the locking element and the catch orifice after the dispensing element has effected the substance dispensing operation once, the device can no longer be operated to dispense another dose.

2. The injection device as claimed in claim 1, wherein the dispensing element is one of a knob or rotating knob by which a dose to be dispensed can be set.

3. The injection device as claimed in claim 1, wherein the at least one catch orifice is arranged on a face of the dispensing element and is able to interact with the locking element to form a retaining connection.

4. The injection device as claimed in claim 3, wherein the at least one catch orifice comprises one of at least one cam or recess.

5. The injection device as claimed in claim 4, wherein the retaining connection is a positive connection between the catch orifice cam or recess and the locking element.

6. The injection device as claimed in claim 3, wherein at least two catch orifices are associated with the dispensing element, the catch orifices extending in a circumferential direction relative to the dispensing element and axially offset from one another for co-operating with the locking element.

7. The injection device as claimed in claim 6, wherein the catch orifices are on one of an external face or internal face of the dispensing element.

8. The injection device as claimed in claim 7, wherein the catch orifices are recesses.

9. The injection device as claimed in claim 3, wherein at least one of one of a web or groove is on an external face of the dispensing element, the at least one of one of a web or groove complementing at least one of a groove or web associated with the injection device to form an anti-rotation lock.

10. The injection device as claimed in claim 1, wherein the dispensing element comprises a dose setting position in which the dispensing element is rotatable to set a selected dose, and upon setting the dose, the dispensing element is extracted by the user to a loading position in which the coupling engagement between the locking element and the at least one catch orifice is established.

11. The injection device as claimed in claim 10, wherein in the loading position, the coupling engagement prevents the dispensing element from rotating relative to the toothed rack.

12. The injection device as claimed in claim 10, wherein upon the user pushing the dispensing element in the dispensing direction into the housing, the toothed rack is carried by the dispensing element.

13. The injection device as claimed in claim 1, wherein the dispensing element comprises a retained position in which the dispensing element is releasably retained by the locking element and is prevented from rotating, and a dosing position, which is reached by the user pulling the dispensing element out from the housing, and in the dosing position, the dispensing element is rotatable to select a dose.

14. The injection device as claimed in claim 13, wherein upon selecting the dose, the dispensing element is pushed into the housing and at least one of the at least one catch orifices engages with the locking element to form the coupling engagement.

15. The injection device as claimed in claim 14, wherein the dispensing element further comprises at least one of one of a web or groove on an external face of the dispensing element, the at least one of one of a web or groove complementing at least one of a groove or web associated with the injection device to form an anti-rotation lock, and upon effecting the substance dispensing operation, the at least one groove or web and the complementing at least one groove or web engage to form the anti-rotation lock.

16. The injection device as claimed in claim 1, wherein the locking element comprises a radially flexing member.

17. A method of locking an injection device for dispensing a dose of a substance after a dose has been dispensed, the method comprising:

providing an injection device comprising;

a housing;

a guide sleeve arranged in the housing, the guide sleeve comprising one or more lugs;

a dispensing element which can be displaced relative to the housing by a user pulling the dispensing element out of the housing or the user pushing the dispensing element into the housing, the dispensing element comprising at least one catch orifice; and

a toothed rack arranged in the housing and guided by the guide sleeve, which can be displaced relative to the housing and the guide sleeve, the toothed rack comprising an end configured to engage with a stopper, a plurality of teeth disposed at a middle portion of the toothed rack and a locking element arranged at an end opposite the end configured to engage with the stopper, wherein the plurality of teeth are configured to engage with the one or more lugs to allow the toothed rack to move in a dispensing direction but not in a direction opposite the dispensing direction, and the locking element is configured to form a coupling engagement with the catch orifice and to remain substantially unengaged with the catch orifice until after a dose setting operation is complete; and

locking the dispensing element associated with the injection device before or during dispensing a dose and at least after dispensing the dose whereby, locking is established due to an engagement between the at least one lug and the teeth and the coupling engagement between the locking element and the catch orifice after a dose has been dispensed once, and the device can no longer be operated to dispense another dose.

18. The method according to claim 17, further comprising the step of setting the dose using a setting element retained relative to the injection device by one of static friction or a catch mechanism.

19. An injection device for dispensing a dose of a substance, the device comprising a housing, an ampoule holder displaceable relative to the housing, a dual chamber ampoule accommodated in the ampoule holder, a guide sleeve arranged in the housing, the guide sleeve comprising one or more lugs, a dispensing element displaceable relative to the housing to set a dose of substance to be administered and to effect a dispensing operation, the dispensing element comprising at least one catch orifice, and a toothed rack arranged in the housing and guided by the guide sleeve, which can be displaced relative to the housing and the guide sleeve, the toothed rack comprising an end configured to engage with a stopper, a plurality of teeth disposed at a middle portion of the toothed rack and a locking element arranged at an end opposite the end configured to engage with a stopper, the plurality of teeth configured to engage with the one or more lugs to allow the toothed rack to move in a dispensing direction but not in a direction opposite the dispensing direction, the locking element coupleable to the dispensing element before or during dispensing a dose and at least after the dose has been dispensed in a dispensing operation and configured to remain substantially unengaged with the at least one catch orifice until after a dose setting operation is complete, whereby, due to an engagement between the at least one lug and the teeth and the coupling engagement between the locking element and the catch orifice after the dispensing element has effected the dispensing operation once, the device can no longer be operated to dispense another dose, and wherein the injection device is configured such that a first substance and a second substance contained in the dual chamber ampoule are admixed as the ampoule holder is displaced relative to the housing.

20. An injection device for dispensing a dose of a substance, the device comprising a housing, an ampoule holder displaceable relative to the housing, a guide sleeve arranged in the housing, the guide sleeve comprising one or more lugs, a dispensing element displaceable relative to the housing, the dispensing element comprising at least one catch orifice, and a toothed rack arranged in the housing and guided by the guide sleeve, which can be displaced relative to the housing and the guide sleeve, the toothed rack comprising an end configured to engage with a stopper, a plurality of teeth disposed at a middle portion of the toothed rack and a locking element arranged at an end opposite the end configured to engage with the stopper, the plurality of teeth configured to engage with the one or more lugs to allow the toothed rack to move in a dispensing direction but not in a direction opposite the dispensing direction, wherein the locking element can be coupled with the dispensing element before or during a substance dispensing operation and at least after the substance dispensing operation and is configured to remain substantially unengaged with the catch orifice until after a dose setting operation is complete, whereby, after the dispensing element has effected the dispensing operation once, the device can no longer be operated to dispense another dose, wherein in an initial state the dispensing element is positioned relative to the housing such that the dispensing element cannot be grasped by a user, and wherein the ampoule holder is coupled to the dispensing element such that as the ampoule holder is displaced relative to the housing the dispensing element is moved proximally from the initial position to a dose setting position.