Selective adherence of stent-graft coverings

• US 8,012,194 B2
• Filed: 02/27/2006
• Issued: 09/06/2011
• Est. Priority Date: 09/30/1998
• Status: Active Grant

• Current Assignee: Bard Peripheral Vascular Incorporated (Becton, Dickinson & Co)
• Original Assignee: Bard Peripheral Vascular Incorporated (Becton, Dickinson & Co)
• Inventors: Randall, Scott L., Banas, Christopher E., Edwin, Tarun J., McCrea, Brendan
• Primary Examiner(s): TRUONG, KEVIN THAO
• Application Number:
  US11/363,689
• Publication Number:
  US 20060155369A1
• Time in Patent Office: 2,017 Days
• Field of Search: 623/1.11, 623/1.13, 623/1.19, 623/1.23, 623/1.16, 623/1.44, 606191-198
• US Class Current: 623/1.13
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas
• CPC Class Codes: A61F 2250/0014 having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
• CPC Class Codes: A61F 2250/0039 differing in diameter
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: B29C 65/02 by heating, with or without pressure
• CPC Class Codes: B29C 65/48 using adhesives , i.e. using supplementary joining material; solvent bonding
• CPC Class Codes: B29L 2031/753 Medical equipment; Accessories therefor bloodbags, medical bags B29L2031/7148; artificial eyes B29L2011/0008

Abstract

An endoluminal prosthesis including a first polymer member bonded to a second polymer member to selectively encapsulate a stent. Selective bonding between the first and second polymer members results in unbonded regions or pockets that accommodate movement of the stent, permitting compression of the prosthesis using minimal force and enabling collapse of the prosthesis to a low profile. The pockets are believed to encourage enhanced cellular penetration for rapid healing and may contain bioactive substances.

Claims

1. An endoluminal prosthesis, comprising:

a stent including a plurality of interconnected elements and a plurality of interstices between adjacent elements;

a first generally tubular polymer member bonded to a second generally tubular polymer member through the interstices by a plurality of bonds, the stent positioned between the first and second polymer members; and

a plurality of pockets between adjacent bonds that permit movement of the stent within the pockets when the prosthesis is collapsed from a first diameter to a second diameter smaller than the first diameter wherein the stent has a length greater than the first and second polymer members.

2. The endoluminal prosthesis according to claim 1, wherein the stent has approximately the same length as the first and second polymer members.

3. The endoluminal prosthesis according to claim 1, wherein the stent includes at least one flared end.

4. The endoluminal prosthesis according to claim 1, wherein at least one of the pockets contains a drug.

5. The endoluminal prosthesis according to claim 4, wherein the drug is selected from the group consisting essentially of anticoagulant drugs, anti-inflammatory drugs, or therapeutic drugs to prevent restenosis or local thrombosis, and combinations thereof.

6. The endoluminal prosthesis according to claim 1, further comprising an adhesive selectively disposed between the first and second polymer members.

7. The endoluminal prosthesis according to claim 6, wherein the adhesive is selected from the group consisting essentially of an aqueous dispersion of polytetrafluoroethylene, a polytetrafluoroethylene tape, fluoroethylpolypropylene (FEP), or tetrafluoroethylene, and combinations thereof.

8. The endoluminal prosthesis according to claim 6, wherein the adhesive is activatable via one of either electromagnetic energy or ultraviolet energy.

9. The endoluminal prosthesis according to claim 1, further comprising a thermoplastic polymer disposed between the first and second polymer members.

10. The endoluminal prosthesis according to claim 9, wherein the thermoplastic polymer is selected from the group consisting essentially of polyethylene, polypropylene, polyurethane, or polyethylene terephthalate, and combinations thereof.

11. The endoluminal prosthesis according to claim 1, wherein the stent is a self-expanding stent.

12. The endoluminal prosthesis according to claim 1, wherein the first and second polymer members are comprised of expanded polytetrafluoroethylene.

13. The endoluminal prosthesis according to claim 1, wherein the first and second polymer members are fully bonded to one another through the interstices at a first and second end of the stent.

14. The endoluminal prosthesis according to claim 1, wherein the bonds have a length and are arranged parallel to a longitudinal axis of the prosthesis, such that each of the bonds extends across at least one stent element.

15. The endoluminal prosthesis according to claim 14, wherein each of the bonds extends from a first end of the stent to a second end of the stent, and wherein adjacent bonds are circumferentially spaced from one another.

16. The endoluminal prosthesis according to claim 1, wherein the bonds have a length and are arranged orthogonal to a longitudinal axis of the prosthesis within the interstices such that the bonds span interconnecting members between the stent elements.

17. The endoluminal prosthesis according to claim 16, wherein the bonds extend about the entire circumference of the prosthesis, and wherein one bond is positioned between each stent element.

18. An endoluminal prosthesis, comprising:

a stent including a plurality of interconnected struts, each strut having a plurality of circumferentially arranged cells, each cell having an open region bounded by a border;

a first generally tubular polymer member disposed adjacent an inner surface of the stent; and

a second generally tubular polymer member disposed adjacent an outer surface of the stent, the first and second polymer members bonded to one another through the open regions of the cells to form a plurality of pockets in which portions of the struts are permitted movement when the prosthesis is collapsed from a first diameter to a second diameter smaller than the first diameter wherein the pockets having disposed therein at least one of a fluid and a bioactive substance.