Polyoxyalkylene derivative

• US 8,012,488 B2
• Filed: 02/17/2006
• Issued: 09/06/2011
• Est. Priority Date: 02/18/2005
• Status: Active Grant

• Current Assignee: NOF Corporation
• Original Assignee: NOF Corporation
• Inventors: Yamamoto, Yuji, Yoshioka, Hiroki, Nakamoto, Kenichiro, Sakanoue, Kenji
• Primary Examiner(s): Wu; David
• Assistant Examiner(s): JONES JR., ROBERT STOCKTON
• Application Number:
  US11/816,611
• Publication Number:
  US 20090023859A1
• Time in Patent Office: 2,027 Days
• Field of Search: 514/15, 514/16, 514/17, 514/18, 514/19, 514/716, 514/773, 514/21.5, 514/21.6, 514/21.7, 514/21.8, 514/21.9, 525/54.1, 525/430, 530/345, 424/194.1
• US Class Current: 424/194.1
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61K 47/65 Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
• CPC Class Codes: C07K 1/1077 by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Abstract

A novel polyoxyalkylene derivative represented by the following formula (1), wherein each symbol is as defined in the specification, which has a functional group capable of reacting with various physiologically active substances according to the object is provided.

Claims

1. A polyoxyalkylene derivative represented by the following formula (1)

2. The polyoxyalkylene derivative of claim 1, wherein Z is a peptide residue consisting of 2 to 10 amino acid residues, wherein one or more amino acid residues have a side chain containing a functional group selected from the group consisting of an amino group, a carboxyl group, a thiol group and a hydroxyl group.

3. The polyoxyalkylene derivative of claim 2, wherein Z is a peptide residue consisting of 2 to 10 amino acid residues, wherein one or more amino acid residues are selected from the group consisting of lysine, aspartic acid, glutamic acid, cysteine and serine.

4. The polyoxyalkylene derivative of claim 3, wherein Z is a peptide residue consisting of 2 to 10 amino acid residues selected from the group consisting of lysine, aspartic acid and glutamic acid.

5. The polyoxyalkylene derivative of claim 1, wherein j¹ is 0, j² is 1-8 and k is 3-8.

6. The polyoxyalkylene derivative of claim 5, wherein j² is 1.

7. The polyoxyalkylene derivative of claim 1, wherein j¹ is 1-8.

8. The polyoxyalkylene derivative of claim 7, wherein j² is 0.

9. The polyoxyalkylene derivative of claim 7, wherein j¹ is 1.

10. The polyoxyalkylene derivative of claim 7, wherein j¹ 2-8.

11. The polyoxyalkylene derivative of claim 7, wherein j² is 1-8.

12. The polyoxyalkylene derivative of claim 1, wherein Z is a peptide residue consisting of 3 to 8 amino acid residues, wherein one or more amino acid residues are selected from the group consisting of glycine, lysine, glutamic acid, cysteine and aspartic acid.

13. The polyoxyalkylene derivative of claim 1, wherein R is a methyl group and OA is an oxyethylene group.

14. The polyoxyalkylene derivative of claim 1, wherein X¹ and X² are each independently a group selected from the group consisting of the following formulas (a)-(o):

15. The polyoxyalkylene derivative of claim 8, wherein j¹ is 1.

16. The polyoxyalkylene derivative of claim 5, wherein X² is a group selected from the group consisting of the following formulas (a)-(o):

17. The polyoxyalkylene derivative of claim 7, wherein X¹ and X² are each independently a group selected from the group consisting of the following formulas (a)-(o):