Antibodies to human zcytor17 ligand
First Claim
Patent Images
1. An isolated antibody or antibody fragment thereof that specifically binds to a polypeptide selected from the group consisting of:
- (a) the polypeptide consisting of amino acid residues 38 to 152 as shown in SEQ ID NO;
2;
(b) the polypeptide consisting of amino acid residues 27 to 164 as shown in SEQ ID NO;
2;
(c) the polypeptide consisting of amino acid residues 24 to 164 as shown in SEQ ID NO;
2; and
(d) the polypeptide consisting of amino acid residues 1 to 164 as shown in SEQ ID NO;
2.
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Abstract
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
96 Citations
25 Claims
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1. An isolated antibody or antibody fragment thereof that specifically binds to a polypeptide selected from the group consisting of:
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(a) the polypeptide consisting of amino acid residues 38 to 152 as shown in SEQ ID NO;
2;(b) the polypeptide consisting of amino acid residues 27 to 164 as shown in SEQ ID NO;
2;(c) the polypeptide consisting of amino acid residues 24 to 164 as shown in SEQ ID NO;
2; and(d) the polypeptide consisting of amino acid residues 1 to 164 as shown in SEQ ID NO;
2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An isolated mixture of polyclonal antibodies or antigen-binding fragments thereof that specifically bind to a polypeptide selected from the group consisting of:
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(a) the polypeptide consisting of amino acid residues 38 to 152 as shown in SEQ ID NO;
2;(b) the polypeptide consisting of amino acid residues 27 to 164 as shown in SEQ ID NO;
2;(c) the polypeptide consisting of amino acid residues 24 to 164 as shown in SEQ ID NO;
2; and(d) the polypeptide consisting of amino acid residues 1 to 164 as shown in SEQ ID NO;
2.
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11. An isolated antibody or antibody fragment thereof that specifically binds an epitope of a polypeptide consisting of the amino acid sequence as shown in SEQ ID NO:
- 2, wherein the antibody or antibody fragment blocks or reduces the binding of a polypeptide selected from the group consisting of;
(a) the polypeptide comprising amino acid residues 38 to 152 as shown in SEQ ID NO;
2;(b) the polypeptide comprising amino acid residues 27 to 164 as shown in SEQ ID NO;
2;(c) the polypeptide comprising amino acid residues 24 to 164 as shown in SEQ ID NO;
2; and(d) the polypeptide comprising amino acid residues 1 to 164 as shown in SEQ ID NO;
2to its receptor. - View Dependent Claims (12)
- 2, wherein the antibody or antibody fragment blocks or reduces the binding of a polypeptide selected from the group consisting of;
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13. An isolated antibody or antibody fragment thereof, wherein the antibody or antibody fragment specifically binds to a polypeptide selected from the group consisting of:
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(a) the polypeptide consisting of amino acid residues 54 to 59 of SEQ ID NO;
2;(b) the polypeptide consisting of amino acid residues 129 to 134 of SEQ ID NO;
2;(c) the polypeptide consisting of amino acid residues 35 to 40 of SEQ ID NO;
2;(d) the polypeptide consisting of amino acid residues 33 to 38 of SEQ ID NO;
2;(e) the polypeptide consisting of amino acid residues 126 to 131 of SEQ ID NO;
2; and(f) the polypeptide consisting of amino acid residues 113 to 118 of SEQ ID NO;
2. - View Dependent Claims (14)
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15. An isolated antibody or antibody fragment thereof that specifically binds a polypeptide encoded by a polynucleotide encoding amino acids 27 to 164 of SEQ ID NO:
- 2, wherein the polypeptide is purified from a cell culture.
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16. An isolated antibody or antibody fragment thereof that specifically binds to a polypeptide whose amino acid sequence consists of a portion of SEQ ID NO:
- 2, wherein the portion is at least 30 amino acids in length.
- View Dependent Claims (17, 18)
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19. An isolated mixture of polyclonal antibodies or antigen-binding fragments thereof that specifically bind to a polypeptide selected from the group consisting of:
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(a) the polypeptide consisting of amino acid residues 54 to 59 of SEQ ID NO;
2;(b) the polypeptide consisting of amino acid residues 129 to 134 of SEQ ID NO;
2;(c) the polypeptide consisting of amino acid residues 35 to 40 of SEQ ID NO;
2;(d) the polypeptide consisting of amino acid residues 33 to 38 of SEQ ID NO;
2;(e) the polypeptide consisting of amino acid residues 126 to 131 of SEQ ID NO;
2; and(f) the polypeptide consisting of amino acid residues 113 to 118 of SEQ ID NO;
2.
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20. An isolated antibody or antibody fragment thereof, wherein the antibody or antibody fragment specifically binds amino acid residues 54 to 59 of SEQ ID NO:
- 2.
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21. An isolated antibody or antibody fragment thereof, wherein the antibody or antibody fragment specifically binds amino acid residues 129 to 134 of SEQ ID NO:
- 2.
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22. An isolated antibody or antibody fragment thereof, wherein the antibody or antibody fragment specifically binds amino acid residues 35 to 40 of SEQ ID NO:
- 2.
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23. An isolated antibody or antibody fragment thereof, wherein the antibody or antibody fragment specifically binds amino acid residues 33 to 38 of SEQ ID NO:
- 2.
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24. An isolated antibody or antibody fragment thereof, wherein the antibody or antibody fragment specifically binds amino acid residues 126 to 131 of SEQ ID NO:
- 2.
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25. An isolated antibody or antibody fragment thereof, wherein the antibody or antibody fragment specifically binds amino acid residues 113 to 118 of SEQ ID NO:
- 2.
Specification