Variable voltage compliance for current output generator

• US 8,014,866 B2
• Filed: 07/13/2006
• Issued: 09/06/2011
• Est. Priority Date: 07/13/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Haefner, Paul A.
• Primary Examiner(s): Patel; Niketa
• Assistant Examiner(s): EL-KAISSI, HIBA CARINE
• Application Number:
  US11/457,385
• Publication Number:
  US 20080015657A1
• Time in Patent Office: 1,881 Days
• Field of Search: 607 2- 8, 607/28, 607/115, 607/116
• US Class Current: 607/28
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3615 Intensity
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371

Abstract

A system for providing stimulation current in implantable medical devices is provided. One aspect of this disclosure relates to an apparatus including a power supply terminal adapted to be connected to a power supply. The apparatus embodiment also includes circuitry connected to the power supply terminal and adapted to detect a parameter dependent on tissue/electrode impedance. The apparatus embodiment further includes a current output pulse generator adapted to deliver electrical therapy. The current generator includes an adjustable compliance voltage source connected to the power supply terminal. The compliance voltage source has a programmable amplitude and is adapted to provide different potentials for different tissue/electrode interface impedances. According to various embodiments, the apparatus embodiment also includes at least one stimulating electrode, and the current generator is adapted to deliver electrical therapy using the electrode. Other aspects and embodiments are provided herein.

Claims

1. An apparatus for delivering electrical neural stimulation therapy to a patient comprising an implantable medical device and an external device, the implantable medical device comprising:

a power supply terminal adapted to be connected to a power supply, circuitry connected to the power supply terminal and adapted to detect tissue/electrode interface impedances; and

a current output pulse generator comprising a programmed amplitude of stimulation current, wherein the generator is adapted to deliver electrical neural stimulation therapy at the programmed amplitude, the generator further comprising;

an adjustable compliance voltage source connected to the power supply terminal, the voltage source comprising an adjustable voltage level and is adapted to provide different potentials for different tissue/electrode interface impedances; and

a controller adapted to receive the detected impedances, maintain the programmed amplitude of stimulation current for the different tissue/electrode interface impedances and adjust the compliance voltage source by adjusting the voltage level based on the programmed amplitude of the stimulation current and the detected impedances.

2. The apparatus of claim 1, wherein the voltage source is adapted to be adjusted using an electronic feedback loop to maintain a fixed voltage differential between the compliance voltage level and a load voltage.

3. The apparatus of claim 1, wherein the voltage source is adapted to be adjusted using a look-up table that includes measured tissue/electrode interface impedance and a desired level of stimulation current.

4. The apparatus of claim 1, wherein the external device is adapted to communicate with the implantable device for adjusting the compliance voltage source.

5. The apparatus of claim 4, wherein the external device comprises an advanced patient management system (APM).

6. An apparatus for delivering electrical neural stimulation therapy to a patient, comprising an implantable medical device and an external device, the implantable medical device comprising:

a power supply, circuitry connected to the power supply and adapted to detect tissue/electrode interface impedances; and

a current output pulse generator comprising a programmed amplitude of stimulation current, wherein the generator is adapted to deliver electrical neural stimulation therapy at the programmed amplitude, the generator further comprising;

an adjustable compliance voltage source connected to the power supply, the voltage source adapted to provide different potentials for different tissue/electrode interface impedances and comprises;

an adjustable voltage level;

a supply capacitor;

two variable current sources connected in parallel with the supply capacitor; and

a plurality of switches connected to the current sources and supply capacitor, the switches adapted to control the delivery of electrical neural stimulation therapy, wherein the pulse generator is adapted to receive the detected impedances, maintain the programmed amplitude of stimulation current for the different tissue/electrode interface impedances and adjust the compliance voltage source by adjusting the voltage level based on the programmed amplitude of the stimulation current and the detected impedances.

7. The apparatus of claim 6, wherein the voltage source is adjustable over a range from 1V to 100V.

8. The apparatus of claim 6, wherein the detected tissue/electrode interface impedances include a range of impedance values from 100 ohms to 2 kohms.

9. The apparatus of claim 6, wherein the current output pulse generator is adapted to deliver electrical current over a range from 5 μ

A to 10 mA.

10. The apparatus of claim 6, further comprising:

at least one stimulating electrode, wherein the current output pulse generator is adapted to deliver electrical therapy using the at least one electrode.

11. The apparatus of claim 10, wherein the neural stimulation therapy includes vagal stimulation therapy.

12. The apparatus of claim 10, wherein the at least one stimulating electrode includes a transvascular electrode.

13. The apparatus of claim 10, wherein the at least one stimulating electrode includes nerve cuff electrode.

14. An apparatus for delivering electrical neural stimulation therapy to a patient comprising:

means for applying neural stimulation therapy comprising a programmed amplitude of stimulation current, wherein the means for applying uses a current output pulse generator comprising;

an adjustable compliance voltage source, the voltage source comprising an adjustable voltage level and is adapted to provide different potentials for different tissue/electrode interface impedances;

implantable means for detecting tissue/electrode interface impedances; and

means for adjusting the voltage level of the adjustable compliance voltage source, the adjusting means including means for receiving the detected impedances and adapted to adjust the voltage level to a voltage amplitude to maintain the programmed amplitude of stimulation current for different tissue/electrode interface impedances by adjusting the voltage level based on the programmed amplitude of the stimulation current and the detected impedances;

wherein the adjustable compliance voltage source is connected to the detecting means and the stimulating means.

15. The system of claim 14, wherein the system is fully implantable.

16. The system of claim 14, wherein the stimulating means and detecting means are implantable.

17. The system of claim 14, further comprising an enclosure adapted to house the stimulating means, detecting means and adjusting means.

18. The system of claim 14, further comprising an enclosure adapted to house the stimulating means and detecting means.

19. A method for delivering electrical neural stimulation therapy to a patient, comprising:

providing implantable circuitry adapted to detect tissue/electrode interface impedances; and

providing a current output pulse generator comprising a programmed amplitude of stimulation current, wherein the generator is adapted to deliver electrical neural stimulation therapy at the programmed amplitude, the generator further comprising;

an adjustable compliance voltage source connected to the power supply, the voltage source adapted to provide different potentials for different tissue/electrode interface impedances and comprises;

an adjustable voltage level;

a supply capacitor;

two variable current sources connected in parallel with the supply capacitor; and

a plurality of switches connected to the current sources and supply capacitor, the switches adapted to control the delivery of electrical neural stimulation therapy, wherein the pulse generator is adapted to receive the detected impedances, maintain the programmed amplitude of stimulation current for the different tissue/electrode interface impedances and adjust the compliance voltage source by adjusting the voltage level based on the programmed amplitude of the stimulation current and the detected impedances.

20. The method of claim 19, wherein providing a current output pulse generator includes providing the voltage source adapted to be adjusted using an electronic feedback loop to maintain a fixed voltage differential between the compliance voltage level and a load voltage.

21. The method of claim 19, wherein providing a current output pulse generator includes providing the voltage source adapted to be adjusted using an electronic feedback loop to maintain a fixed voltage differential between the compliance voltage level and a load voltage.

22. The method of claim 19, wherein providing a current output pulse generator includes providing the voltage source adapted to be adjusted using an electronic feedback loop to maintain a fixed voltage differential between the compliance voltage level and a load voltage.

23. A method for delivering electrical neural stimulation therapy to a patient, comprising:

applying electrical neural stimulation therapy at a programmed amplitude of stimulation current using a current output pulse generator, wherein the output pulse generator comprises;

an adjustable compliance voltage source, the voltage source comprising an adjustable voltage level and is adapted to provide different potentials for different tissue/electrode interface impedances;

detecting tissue/electrode interface impedances;

using the detected impedances to determine an appropriate voltage level for the adjustable compliance voltage source to maintain the programmed amplitude of stimulation current for different tissue/electrode interface impedances; and

adjusting the voltage level to the appropriate voltage amplitude based on the programmed amplitude of the stimulation current and the detected impedances.

24. The method of claim 23, wherein applying neural stimulation therapy includes applying vagal nerve stimulation therapy.

25. The method of claim 23, further comprising:

adjusting the voltage source based on the programmed amplitude of the stimulation current and the detected impedances using a supply capacitor.