Central venous catheter assembly for measuring physiological data for cardiac output determination and method of determining cardiac output

• US 8,016,766 B2
• Filed: 10/24/2008
• Issued: 09/13/2011
• Est. Priority Date: 11/23/2007
• Status: Active Grant

• Current Assignee: PULSION Medical Systems SE (Getinge AB)
• Original Assignee: Pulsion Medical Systems AG
• Inventors: Goedje, Oliver, Joeken, Stephan, Veeck, Marcus, Scheier, Joerg
• Primary Examiner(s): Patel; Niketa
• Assistant Examiner(s): Vorrhees; Catherine
• Application Number:
  US12/288,979
• Publication Number:
  US 20090137917A1
• Time in Patent Office: 1,054 Days
• Field of Search: 600504-505, 600508-527
• US Class Current: 600/526
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/028 by thermo-dilution
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01F 1/7044 using thermal tracers
• CPC Class Codes: G01F 1/7084 using thermal detecting arrangements
• CPC Class Codes: G01F 15/0755 involving digital counting

Abstract

The central venous sensor assembly comprises a catheter body with several proximal ports. The catheter portion placed in the vena cava superior is equipped with a proximal flux measurement unit, and the catheter portion placed in the vena cava inferior is equipped with a distal flux measurement unit. A first input channel supplies a measurement signal indicative of a flux vp to the evaluation unit from which the latter calculates a blood flow in the vena cava superior. Likewise, a second input channel supplies a measurement signal indicative of a flux vd to the evaluation unit from which the latter calculates a blood flow rate in the vena cava inferior. Due to continuity, the sum of the flow rates in the upper and lower central veins corresponds to the flow rate through the right heart and in the pulmonary artery and thus to cardiac output.

Claims

1. A central venous sensor assembly for measuring physiological data for cardiac output determination, said measurement assembly comprising:

a distal intravascular portion for placement in the vena cava inferior of a patient and a proximal intravascular portion for placement in the vena cava superior of the patient,

a distal flux measurement unit arranged in the distal intravascular portion and adapted to provide raw measurement data for determination of a blood flow in the direction towards the proximal intravascular portion, and

a proximal flux measurement unit arranged in the proximal intravascular portion and adapted to provide raw measurement data for determination of a blood flow in the direction towards the distal intravascular portion,

wherein the venous sensor assembly is connected to an evaluation unit comprising a first input channel for receiving raw measurement data from said distal flux measurement unit and a second input channel for receiving raw measurement data from said proximal flux measurement unit and being adapted to;

determine a first blood flow from the raw measurement data received from said distal flux measurement unit,

determine a second blood flow from the raw measurement data received from said proximal flux measurement unit, and

determine said cardiac output as a sum of said first blood flow and said second blood flow.

2. The central venous sensor assembly according to claim 1, wherein at least one of said flux measurement units comprises a heat transfer device for determining an amount of energy needed per unit time to maintain a given temperature of the heat transfer device.

3. The central venous sensor assembly according to claim 1, wherein said distal flux measurement unit comprises:

a distal temperature influencing element for influencing the temperature of blood passing said distal temperature influencing element, and

a distal temperature sensor, said distal temperature sensor being arranged in a position proximal with respect to said distal temperature influencing element.

4. The central venous sensor assembly according to claim 3, wherein said distal temperature influencing element is a heating element.

5. The central venous sensor assembly according to claim 3, wherein said distal temperature influencing element is a cooling element.

6. The central venous sensor assembly according to claim 1, wherein said proximal flux measurement unit comprises:

a proximal temperature influencing element for influencing the temperature of blood passing said proximal temperature influencing element, and

a proximal temperature sensor, said proximal temperature sensor being arranged in a position distal with respect to said proximal temperature influencing element.

7. The central venous sensor assembly according to claim 6, wherein said proximal temperature influencing element is a cooling element.

8. The central venous sensor assembly according to claim 6, wherein said proximal temperature influencing element is a heating element.

9. The central venous sensor assembly according to claim 1, said sensor assembly including a probe comprising a distal probe portion for placement in the vena cava inferior of the patient and a proximal probe portion for placement in the vena cava superior of the patient, wherein said distal flux measurement unit is arranged in the distal probe portion and said proximal flux measurement unit is arranged in the proximal probe portion.

10. The central venous sensor assembly according to claim 9, which further comprises a catheter through which said probe can be inserted to be placed in the vena cava superior and vena cava inferior of said patient.

11. The central venous sensor assembly according to claim 10, wherein said catheter comprises a pressure measurement lumen.

12. The central venous sensor assembly according to claim 1, said sensor assembly including:

a central venous catheter comprising an elongated catheter body for placement in the vena cava superior of a patient and a probe lumen, and

a probe adapted for being inserted through said probe lumen, said probe having a distal probe portion for placement in the vena cava inferior of the patient,

wherein said distal flux measurement unit is arranged in the distal probe portion and said proximal flux measurement unit is integrated in the catheter body.

13. The central venous sensor assembly according to claim 12, wherein said catheter comprises a pressure measurement lumen.

14. The central venous sensor assembly according to claim 1, said sensor assembly including a central venous catheter having an elongated catheter body with a distal body portion for placement in the vena cava inferior of a patient and a proximal body portion for placement in the vena cava superior of the patient,

wherein said distal flux measurement unit is arranged in the distal body portion and said proximal flux measurement unit is arranged in the proximal body portion.

15. The central venous sensor assembly according to claim 14, wherein said catheter comprises a pressure measurement lumen.

16. The central venous sensor assembly according to claim 1, wherein said evaluation unit is further adapted to calibrate cardiac output determination using at least one of:

a reference cardiac output determined by a method other then using said raw measurement data from said distal flux measurement unit and said proximal flux measurement unit,

a calibration value representing a vessel diameter, and

a calibration value representing a vessel cross sectional area.

17. The central venous sensor assembly according to claim 16, wherein said evaluation unit is further adapted to calibrate cardiac output determination using at least one of:

a calibration value representing a vessel diameter, and

a calibration value representing a vessel cross sectional area, and

wherein at least one of said calibration value representing a vessel diameter or said calibration value representing a vessel cross sectional area is determined by an estimation depending on other patient data, such as size, weight, age and gender.

18. The central venous sensor assembly according to claim 16, wherein said evaluation unit is further adapted to calibrate cardiac output determination using at least one of:

a calibration value representing a vessel diameter, and

a calibration value representing a vessel cross sectional area, and

wherein at least one of said calibration value representing a vessel diameter or said calibration value representing a vessel cross sectional area is determined by measurement.

19. A method for determining cardiac output of a patient comprising the steps of:

receiving raw measurement data from a first flux measurement unit which measures flux-related raw measurement data in the vena cava inferior,

receiving raw measurement data from a second flux measurement unit which measures flux-related raw measurement data in the vena cava superior,

determining a first blood flow from the raw measurement data received from said first flux measurement unit,

determining a second blood flow from the raw measurement data received from said second flux measurement unit, and

determining said cardiac output as a sum of said first blood flow and said second blood flow.

20. The method according to claim 19, wherein cardiac output determination is calibrated using at least one of:

a reference cardiac output determined by a method other then using said raw measurement data from said first flux measurement unit and said second flux measurement unit,

a calibration value representing a vessel diameter, and

a calibration value representing a vessel cross sectional area.

21. The method according to claim 20, wherein cardiac output determination is calibrated using at least one of:

a calibration value representing a vessel diameter, and

a calibration value representing a vessel cross sectional area,

wherein at least one of said calibration value representing a vessel diameter and said calibration value representing a vessel cross sectional area is determined by performing an estimation depending on other patient data, such as size, weight, age and gender.

22. The method according to claim 20, wherein cardiac output determination is calibrated using at least one of:

a calibration value representing a vessel diameter, and

a calibration value representing a vessel cross sectional area,

wherein at least one of said calibration value representing a vessel diameter or said calibration value representing a vessel cross sectional area is determined by measurement.