Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
First Claim
1. A system, comprising:
- a transdermal drug delivery device adapted to deliver a drug;
an implantable cardiac rhythm management (CRM) device communicatively coupled to the transdermal drug delivery device, the implantable CRM device including;
an ischemia detector adapted to detect an ischemia and produce an ischemia indicating signal in response to a detection of the ischemia;
a drug level detector including a respiratory sensor adapted to sense a respiratory signal as an indication of whether a blood drug concentration is below a predetermined minimum level after a delivery of the drug; and
a drug delivery controller coupled to the ischemia detector and the drug level detector; and
an external device communicatively coupled to the implantable CRM device, the external device including an external user input to receive an external user command,wherein the drug delivery controller is adapted to control the transdermal drug delivery device based on at least one of the ischemia indicating signal, the indication of the blood drug concentration, and the external user command.
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Abstract
A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.
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Citations
20 Claims
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1. A system, comprising:
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a transdermal drug delivery device adapted to deliver a drug; an implantable cardiac rhythm management (CRM) device communicatively coupled to the transdermal drug delivery device, the implantable CRM device including; an ischemia detector adapted to detect an ischemia and produce an ischemia indicating signal in response to a detection of the ischemia; a drug level detector including a respiratory sensor adapted to sense a respiratory signal as an indication of whether a blood drug concentration is below a predetermined minimum level after a delivery of the drug; and a drug delivery controller coupled to the ischemia detector and the drug level detector; and an external device communicatively coupled to the implantable CRM device, the external device including an external user input to receive an external user command, wherein the drug delivery controller is adapted to control the transdermal drug delivery device based on at least one of the ischemia indicating signal, the indication of the blood drug concentration, and the external user command. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification