Techniques for delivery of stem cell and related therapies to treat cardiac conditions

• US 8,016,812 B2
• Filed: 07/22/2010
• Issued: 09/13/2011
• Est. Priority Date: 11/03/2006
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Koh, Steve
• Primary Examiner(s): Patel; Niketa
• Assistant Examiner(s): EL-KAISSI, HIBA CARINE
• Application Number:
  US12/841,944
• Publication Number:
  US 20100286736A1
• Time in Patent Office: 418 Days
• Field of Search: 600/510, 607/3, 607/9, 607/120, 604/522, 604/890.1, 604/502, 604/503, 604/507, 604/508, 604/510, 604/511, 604/66, 604/67, 604/93.01, 128/898
• US Class Current: 604/503
• CPC Class Codes: A61M 2210/125 Heart
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation

Abstract

An exemplary method includes acquiring cardiac electrical activity information, detecting a T wave and, based on the detecting, calling for delivery of matter to the heart where the matter may include one or more of stem cells, progenitor cells, nutrients and drugs. Another exemplary method includes calling for delivery of electrical energy to cells destined for implantation in the body or cells already implanted in the body. Such delivery may be timed according to cardiac electrical activity and/or delivered at an energy level below a capture threshold of neighboring tissue. Various other exemplary technologies are also disclosed.

Claims

1. An implantable apparatus for treating a myocardium, said apparatus comprising:

a structure configured to hold cells and configured for implant in a body at a location outside of a myocardium;

a pump configured to move cells from the cell-holding structure and configured for implant in a body;

acquisition circuitry configured to acquire cardiac electrical activity information and configured for implant in a body;

stimulation circuitry configured to output electrical cardiac pacing pulses and electrical cell conditioning pulses and configured for implant in a body;

a lead configured for implant in a body, the lead having at least one opening, a conduit having a proximal end in fluid communication with the pump and a distal end in fluid communication with the at least one opening, and electrodes at the distal end of the conduit electrically coupled to the stimulation circuitry and adapted for positioning adjacent the myocardium; and

control logic configured for implant in a body and configured to;

detect cardiac events within the information including T waves;

activate the pump so as to deliver cells through the conduit and at least one opening to the myocardium based on the detected T waves; and

activate the stimulation circuitry so as to deliver cardiac pacing pulses through the electrodes to myocardium at a pre-determined rate, and deliver one or more cell conditioning pulses through the electrodes to the one or more cells implanted in the myocardium.

2. The apparatus of claim 1 wherein the delivery of the one or more cell conditioning pulses occurs at a time other than that of a cardiac pacing pulse and wherein each of the one or more cell conditioning pulses comprises an energy insufficient to cause cardiac capture.

3. The apparatus of claim 1 wherein the control logic is further configured to determine a cardiac capture threshold prior to the delivery of one or more cell conditioning pulses.

4. The apparatus of claim 3 wherein the control logic is further configured to determine an energy for each one or more cell conditioning pulses based at least in part on the cardiac capture threshold.

5. The apparatus of claim 1 wherein the control logic is further configured to control the stimulation circuitry so as to deliver the one or more cell conditioning pulses during a myocardial, non-refractory period.

6. The apparatus of claim 1 wherein the control logic is further configured to control the stimulation circuitry so as to deliver the one or more cell conditioning pulses during a myocardial, refractory period.

7. The apparatus of claim 1 wherein the control logic is further configured to detect R waves from the information and to activate the stimulation circuitry to deliver one or more cell conditioning pulses to the one or more cells implanted in the myocardium, based on detected R waves.

8. The apparatus of claim 7 wherein the control logic is further configured to activate the stimulation circuitry so as to deliver one or more conditioning pulses substantially synchronous with a detected R wave.

9. The apparatus of claim 7 wherein the control logic is further configured to activate the stimulation circuitry so as to deliver one or more conditioning pulses at a frequency based at least in part on a detected R wave.

10. The apparatus of claim 7 wherein the control logic is further configured to activate the stimulation circuitry so as to deliver one or more conditioning pulses after expiration of a delay where the delay commences substantially synchronous with a detected R wave.

11. The apparatus of claim 1 wherein the control logic is further configured to activate the pump so as to implant the cells in the myocardium after a detected T wave.

12. The apparatus of claim 1 wherein the control logic is further configured to activate the pump so as to implant the cells in the myocardium after a detected T wave and before a detected R wave.

13. The apparatus of claim 1 wherein the control logic is further configured to activate the pump so as to implant the cells in the myocardium after a detected T wave and before a detected P wave.

14. The apparatus of claim 1 wherein the control logic is further configured to measure impedance between the two electrodes and to determine whether the electrodes are in contact with the myocardium or fluid based on the impedance.

15. The apparatus of claim 1 further comprising a plurality of prongs projecting from the conduit, one or more of the prongs in fluid communication with the at least one opening.

16. The apparatus of claim 15 wherein at least two of the prongs have different lengths.

17. The apparatus of claim 15 wherein the electrodes are at the distal end of the conduit and the plurality of prongs are positioned between the two electrodes.