Bioactive components for incorporation with vaso-occlusive members

• US 8,016,852 B2
• Filed: 04/09/2003
• Issued: 09/13/2011
• Est. Priority Date: 11/10/1998
• Status: Active Grant

• Current Assignee: Stryker European Operations Holdings, LLC (Stryker Corporation)
• Original Assignee: Stryker Corporation, Stryker Nv Operations Limited (Stryker Corporation)
• Inventors: Quan, Kenneth W. Jr., Slaikeu, Paul C., Barry, James, Eder, Joseph C., Wallace, Michael P., Ho, Hanh, Abrams, Robert M., Teoh, Clifford
• Primary Examiner(s): Jackson; Gary
• Assistant Examiner(s): BACHMAN, LINDSEY MICHELE
• Application Number:
  US10/409,796
• Publication Number:
  US 20040093014A1
• Time in Patent Office: 3,079 Days
• Field of Search: 606/191, 606/194, 606/198, 606/200, 606/151, 606/159, 606/192, 623/1.11, D24/143
• US Class Current: 606/200
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 65/04 Polyxylenes
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A vaso-occlusive device is disclosed. The device includes a vaso-occlusive member having a coating disposed thereon. In accordance with one embodiment, the coating comprises a polyacrylic material. In accordance with another embodiment, the coating comprises a polyvinyl alcohol-based material. In accordance with other embodiments, various other materials and coatings are applied to at least a portion of a vaso-occlusive device.

Claims

1. An implantable medical device for at least partially obstructing a neck portion of a vascular aneurysm, comprising:

an occlusion subassembly comprising a central member and a loop of wire having first and second ends connected to the central member, said loop of wire and the central member being of a size and overall flexibility to lodge at the neck portion of the vascular aneurysm; and

a coil attached to and radially disposed about a portion of the loop of wire; and

the occlusion subassembly further comprises a fibrous woven tubular member extending coaxially over at least a portion of the coil, the tubular member comprising a material for encouraging a cellular response.

2. The implantable medical device of claim 1, wherein the tubular member comprises a biodegradable material.

3. The implantable medical device of claims 1, wherein the tubular member comprises a polymeric material.

4. The implantable medical device of claim 1, wherein the tubular member comprises polyglycolic acid.

5. The implantable medical device of claim 1, wherein the tubular member comprises polylactic acid.

6. The implantable medical device of claim 1, wherein the tubular member comprises a mixture of polyglycolic acid and polylactic acid.

7. The implantable medical device of claim 1, wherein the tubular member comprises a copolymer of polyglycolic acid and polylactic acid.

8. The implantable medical device of claim 1, wherein the tubular member is braided.

9. The implantable medical device of claim 1, further comprising a marker coil radially disposed about a portion of the loop of wire.

10. An implantable medical device for at least partially obstructing a neck portion of a vascular aneurysm, comprising:

an occlusion subassembly comprising a central member and a loop of wire having first and second ends connected to the central member, said loop of wire and the central member being of a size and overall flexibility to lodge at the neck portion of the vascular aneurysm; and

a coil attached to and radially disposed about a portion of the loop of wire; and

the occlusion subassembly further comprises a fibrous woven tubular member extending coaxially over at least a portion of the coil, the tubular member comprising a biodegradable material for encouraging a cellular response.

11. The implantable medical device of claim 10, wherein the tubular member comprises a polymeric material.

12. The implantable medical device of claim 10, wherein the tubular member comprises polyglycolic acid.

13. The implantable medical device of claim 10, wherein the tubular member comprises polylactic acid.

14. The implantable medical device of claim 10, wherein the tubular member comprises a mixture of polyglycolic acid and polylactic acid.

15. The implantable medical device of claim 10, wherein the tubular member comprises a copolymer of polyglycolic acid and polylactic acid.

16. The implantable medical device of claim 10, wherein the tubular member is braided.

17. The implantable medical device of claim 10, further comprising a marker coil radially disposed about a portion of the loop of wire.