Apparatus and methods for delivery of multiple distributed stents

• US 8,016,871 B2
• Filed: 06/10/2009
• Issued: 09/13/2011
• Est. Priority Date: 12/03/2001
• Status: Expired due to Term

• Current Assignee: JW Medical Systems Ltd
• Original Assignee: XTENT, Inc.
• Inventors: French, Ron, Andreas, Bernard, Gifford, Hanson S. III, Chew, Sunmi, Deem, Mark E., Will, Allan
• Primary Examiner(s): TRUONG, KEVIN THAO
• Application Number:
  US12/482,227
• Publication Number:
  US 20100004729A1
• Time in Patent Office: 825 Days
• Field of Search: 623/1.11, 623/1.12, 623/1.15, 623/1.16, 606191-198, 604/101.01, 604/101.02, 604/1.16
• US Class Current: 623/1.11
• CPC Class Codes: A61F 2/0095 Packages or dispensers for prostheses or other implants for intraocular lenses A61F2/1691; for dental surgery A61C19/02
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2/966 with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
• CPC Class Codes: A61F 2002/826 more than one stent being applied sequentially
• CPC Class Codes: A61F 2002/828 Means for connecting a plurality of stents allowing flexibility of the whole structure
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/9155 Adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2002/91591 Locking connectors, e.g. using male-female connections
• CPC Class Codes: A61F 2002/9583 Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
• CPC Class Codes: A61F 2210/0033 electrically, e.g. heated by resistor
• CPC Class Codes: A61F 2210/0042 using a fluid, e.g. circulating
• CPC Class Codes: A61F 2250/0071 breakable or frangible

Abstract

Blood vessels and other body lumens are stented using multiple, discreet stent structures. Stent structures may be balloon expandable or self-expanding and are delivered by a delivery catheter which is repositioned to spaced-apart delivery sights. By coating the stents with particular biologically active substances, hyperplasia within and between the implanted stents can be inhibited. An exemplary delivery catheter comprises a catheter body having both a pusher rod for advancing the stents relative to a sheath and a reciprocatable delivery catheter for implanting the stents.

Claims

1. A stent delivery device for delivering a stent to a treatment site in a body lumen, the device comprising:

a catheter shaft having a proximal end and a distal end;

an expandable member coupled with the catheter shaft near the distal end;

a stent positionable over the expandable member in an unexpanded configuration and being radially expandable to an expanded configuration, the stent comprising a plurality of stent segments which are axially separable from each other while the stent segments are in the unexpanded configuration and positioned over the expandable member; and

a constraining sheath coupled to the catheter shaft and positionable to engage a remainder group of the stent segments, wherein the remainder group comprises at least one stent segment, wherein a selected group of stent segments is unconstrained to allow expansion thereof at the treatment site while the remainder group of stent segments is constrained from and axially separable from the selected group of stent segments to form an axial gap between the remainder group of stent segments and the selected group of stent segments, wherein the selected group of stent segments comprises at least two stent segments and is released from the delivery device so that the at least two stent segments are expandable simultaneously by the expandable member while the expandable member carries the remainder group of stent segments in the unexpanded configuration.

2. The stent delivery device of claim 1, wherein the constraining sheath is adapted to constrain expansion of a proximal portion of the expandable member and at least one stent segment of the remainder group of stent segments while the selected group of stent segments is expanded.

3. The stent delivery device of claim 1, wherein the constraining sheath includes a separation valve adapted to engage the stent segments so that a stent segment engaged therewith is retractable in conjunction with the constraining mechanism.

4. The stent delivery device of claim 1, further comprising a pusher axially movable relative the catheter shaft and the constraining sheath, the pusher being configured to engage at least one of the stent segments and prevent proximal displacement thereof as the constraining sheath mechanism is retracted.

5. The stent delivery device of claim 1, wherein the stent segments are unconnected to each other in both the unexpanded and expanded configurations.

6. The stent delivery device of claim 1, wherein the stent segments are connected to each other in the unexpanded configuration and are separable from each other upon expansion.

7. The stent delivery device of claim 1, wherein the deployed selected group of stent segments are connected to each other after expansion.

8. The stent delivery device of claim 7, wherein the deployed selected group of stent segments are connected by bioerodable links.

9. The stent delivery device of claim 1, wherein the stent is composed of a malleable material so as to be plastically deformed during expansion of the expandable member.

10. The stent delivery device of claim 1, wherein the stent segments are bioerodable following deployment.

11. The stent delivery device of claim 1, wherein the stent comprises a therapeutic agent adapted to be released therefrom.

12. The stent delivery device of claim 11, wherein the therapeutic agent inhibits restenosis.

13. The stent delivery device of claim 11, wherein the therapeutic agent is disposed in a bioerodable carrier.

14. The stent delivery device of claim 13, wherein the bioerodable carrier is a polymer.

15. The stent delivery device of claim 14, wherein the polymer is polylactic acid.

16. The stent delivery device of claim 11, wherein the therapeutic agent is coated on an outer surface of the stent.

17. The stent delivery device of claim 1, wherein the constraining sheath has a lubricious surface adapted to reduce friction as the constraining sheath is retracted.

18. The stent delivery device of claim 17, wherein the constraining sheath is coated with a lubricious coating.

19. The stent delivery device of claim 18, wherein an outer surface of the constraining sheath is coated with a lubricious coating.

20. The stent delivery device of claim 18, wherein an inner surface of the constraining sheath is coated with a lubricious coating.

21. The stent delivery device of claim 1, wherein the constraining sheath has a distal portion having a higher column strength than a proximal portion of the constraining sheath.

22. The stent delivery device of claim 1, wherein the constraining sheath is disposed at least partially over the catheter shaft.

23. The stent delivery device of claim 1, wherein the constraining sheath constrains at least a portion of the expandable member.

24. The stent delivery device of claim 1, wherein the constraining sheath constrains at least a portion of the expandable member while a second portion of the expandable member is expanded.