Method for determination of analyte concentrations and related apparatus
First Claim
1. A method for determining the time of sample application, and triggering the start of an electrochemical assay conducted in an electrochemical test cell comprising a working and a counter electrode at which the electrochemical assay is performed, comprising the steps of:
- (a) applying a pulsed voltage, Vw, to the working electrode while holding the voltage, Vc, of the counter electrode constant commencing at a time prior to the introduction of sample to the electrochemical test cell, said pulsed voltage having a pulse frequency;
(b) monitoring the electrochemical test cell for the passage of current between the working and counter electrodes, said passage of current being in the form of current spikes having a frequency equal to the pulse frequency and being indicative of the addition of a sample to the electrochemical test cell, and(c) triggering the start of the electrochemical assay when a plurality of current spikes have been observed, and when said plurality is least a pre-determined fraction of a predetermined number of consecutive current spikes.
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Abstract
A method is provided for determining analyte concentrations, for example glucose concentrations, that utilizes a dynamic determination of the appropriate time for making a glucose measurement, for example when a current versus time curve substantially conforms to a Cottrell decay, or when the current is established in a plateau region. Dynamic determination of the time to take the measurement allows each strip to operate in the shortest appropriate time frame, thereby avoiding using an average measurement time that may be longer than necessary for some strips and too short for others.
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Citations
8 Claims
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1. A method for determining the time of sample application, and triggering the start of an electrochemical assay conducted in an electrochemical test cell comprising a working and a counter electrode at which the electrochemical assay is performed, comprising the steps of:
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(a) applying a pulsed voltage, Vw, to the working electrode while holding the voltage, Vc, of the counter electrode constant commencing at a time prior to the introduction of sample to the electrochemical test cell, said pulsed voltage having a pulse frequency; (b) monitoring the electrochemical test cell for the passage of current between the working and counter electrodes, said passage of current being in the form of current spikes having a frequency equal to the pulse frequency and being indicative of the addition of a sample to the electrochemical test cell, and (c) triggering the start of the electrochemical assay when a plurality of current spikes have been observed, and when said plurality is least a pre-determined fraction of a predetermined number of consecutive current spikes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification