Method of treating a wound with acidified plasma or serum

• US 8,017,157 B2
• Filed: 12/12/2006
• Issued: 09/13/2011
• Est. Priority Date: 05/09/2002
• Status: Expired due to Fees

• Current Assignee: Osiris Therapeutics Incorporated (Smith & Nephew PLC)
• Original Assignee: Osiris Therapeutics Incorporated (Smith & Nephew PLC)
• Inventors: Lee, Gene, Chang, Kyung Hee, Yoo, Won Min, Keum, Ki Chang, Yoo, Nae Choon, Lee, Sang Yup
• Primary Examiner(s): SAUCIER, SANDRA E
• Application Number:
  US11/638,056
• Publication Number:
  US 20070148142A1
• Time in Patent Office: 1,736 Days
• Field of Search: None
• US Class Current: 424/530
• CPC Class Codes: A61K 35/16 Blood plasma; Blood serum umbilical cord blood A61K35/51
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/10 Anti-acne agents

Abstract

The present invention relates to a pharmaceutical composition for the treatment of wounds containing blood plasma or serum and a method for treating wounds effectively by applying said composition to the wound site to normalize the tissue-environment around the site.

Claims

1. A method of treating a wound comprising applying to the wound a pharmaceutically effective amount of a composition consisting essentially of blood plasma or blood serum having a pH of 3.5 to 6.6.

2. The method of claim 1, wherein said composition consists essentially of blood plasma having a pH of 3.5 to 6.6.

3. The method of claim 1, wherein said blood plasma or blood serum is derived from livestock.

4. The method of claim 1, wherein said composition is applied to the wound in an amount of 0.01 to 0.1 g/cm².

5. The method of claim 1, wherein the composition is topically applied.

6. The method of claim 1, wherein the composition is in the form of a cream, an ointment, a gel, or a patch.

7. The method of claim 1, wherein the wound is a contusion, a bruise, a non-healing traumatic wound, a disruption by irradiation, an abrasion, a bone gangrene, laceration, an avulsion, a penetrated wound, a gun shot wound, a cut, a burn, a cold sore, a cutaneous ulcer, xeroderma, skin kefatosis, a break, a rupture, dermatitis, pain by dermatophyte, a wound by surgery, a wound by vascular disorder, a corneal wound, a pressure sore, a bed sore, a wound associated with diabetes, a chronic ulcer, a suture site, a spinal traumatic wound, a gynecological wound, a chemical wound or acne.

8. The method of claim 1, wherein wound associated with diabetes is caused by diabetic cutaneous disorder or poor circulation.

9. The method of claim 1, wherein the wound is a full thickness defect wound.