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IRE-1α substrates

  • US 8,017,331 B2
  • Filed: 11/04/2005
  • Issued: 09/13/2011
  • Est. Priority Date: 11/04/2005
  • Status: Active Grant
First Claim
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1. A substrate for IRE-1α

  • , comprising;

    (a) an oligonucleotide molecule comprising;

    (i) an RNA loop consisting of a cleavage site for IRE-1α

    ; and

    (ii) a nucleotide stem consisting of 4, 5, 6, 7, 8, 9, or 10 nucleotide base pairs; and

    (b) a donor moiety and an acceptor moiety which exhibit a detectable resonance energy transfer when the donor moiety is excited, wherein the donor moiety is conjugated to one of the 5′

    or 3′

    ends of the oligonucleotide molecule and the acceptor moiety is conjugated to the other of the 5′

    or 3′

    ends of the oligonucleotide molecule.

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