Compositions of R(+) and S(−) pramipexole and methods of using the same
First Claim
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1. A method of treating Parkinson'"'"'s disease or the symptoms thereof comprising administering a solid unit dose of a therapeutically effective amount of R(+) pramipexole and an amount of S(−
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
) pramipexole is from 1.5 milligrams to 4.5 milligrams.
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Abstract
Compositions of predetermined amounts of R(+) pramipexole and S(−) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson'"'"'s disease, are provided.
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Citations
42 Claims
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1. A method of treating Parkinson'"'"'s disease or the symptoms thereof comprising administering a solid unit dose of a therapeutically effective amount of R(+) pramipexole and an amount of S(−
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
) pramipexole is from 1.5 milligrams to 4.5 milligrams. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 39, 41)
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
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12. A method of treating Parkinson'"'"'s disease or the symptoms thereof comprising orally administering a unit dose of a therapeutically effective amount of R(+) pramipexole and an amount of S(−
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
) pramipexole is from 1.5 milligrams to 4.5 milligrams. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 42)
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
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23. A method of treating Parkinson'"'"'s disease or the symptoms thereof comprising administering a solid unit dose of a therapeutically effective amount of R(+) pramipexole and an amount of S(−
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
) pramipexole is 4.5 milligrams. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 40)
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
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31. A method of treating Parkinson'"'"'s disease or the symptoms thereof comprising orally administering a unit dose of a therapeutically effective amount of R(+) pramipexole and an amount of S(−
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
) pramipexole is 4.5 milligrams. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38)
- ) pramipexole, wherein said therapeutically effective amount of R(+) pramipexole is from 100 milligrams to 3,000 milligrams and said amount of S(−
Specification