Apparatus for microarray binding sensors having biological probe materials using carbon nanotube transistors
First Claim
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1. An apparatus comprising:
- one or more carbon nanotube transistors on a silicon substrate, the one or more carbon nanotube transistors each including a gate electrode, a source electrode, a drain electrode, and a carbon nanotube channel bridging the source electrode and the drain electrode, wherein the drain electrode and the carbon nanotube channel are covered by insulating layer, wherein the insulating layer insulates the drain electrode and the carbon nanotube channel from an electrolyte solution, wherein the gate electrode is configured to contact the electrolyte solution comprising one or more target biological molecules,one or more specific probe materials immobilized on the insulating layer,an electronic circuitry to detect a change in electrical charge by each of the one or more carbon nanotube transistors due to binding of the one or more specific probe materials with the one or more target biological molecules,a detector to detect the change in electrical charge to directly quantify the amount of a bound target biological molecules; and
an automated sensing system for determining a relative abundance of the specific target biological molecule based on the change in electrical charge.
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Abstract
A microarray apparatus is provided which contains at least one chip having source and drain electrodes positioned on an array of carbon nanotube transistors which allows for electronic detection of nucleic acid hybridizations, thereby affording both increased sensitivity and the capability of miniaturization.
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Citations
28 Claims
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1. An apparatus comprising:
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one or more carbon nanotube transistors on a silicon substrate, the one or more carbon nanotube transistors each including a gate electrode, a source electrode, a drain electrode, and a carbon nanotube channel bridging the source electrode and the drain electrode, wherein the drain electrode and the carbon nanotube channel are covered by insulating layer, wherein the insulating layer insulates the drain electrode and the carbon nanotube channel from an electrolyte solution, wherein the gate electrode is configured to contact the electrolyte solution comprising one or more target biological molecules, one or more specific probe materials immobilized on the insulating layer, an electronic circuitry to detect a change in electrical charge by each of the one or more carbon nanotube transistors due to binding of the one or more specific probe materials with the one or more target biological molecules, a detector to detect the change in electrical charge to directly quantify the amount of a bound target biological molecules; and an automated sensing system for determining a relative abundance of the specific target biological molecule based on the change in electrical charge. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification