Integrated thickness shear mode (TSM) sensor and surface acoustic wave (SAW) device for simultaneous sensing and removal of analytes

• US 8,018,121 B1
• Filed: 06/12/2009
• Issued: 09/13/2011
• Est. Priority Date: 06/12/2008
• Status: Expired due to Fees

• Current Assignee: University of South Florida (State University System of Florida)
• Original Assignee: University of South Florida (State University System of Florida)
• Inventors: Cular, Stefan
• Primary Examiner(s): Benson; Walter
• Assistant Examiner(s): ADDISON, KAREN B
• Application Number:
  US12/483,456
• Time in Patent Office: 823 Days
• Field of Search: 310/313.R, 310/313.D, 71/530.1
• US Class Current: 310/313.00R
• CPC Class Codes: G01N 2291/0255 (Bio)chemical reactions, e.g. on biosensors
• CPC Class Codes: G01N 2291/0256 Adsorption, desorption, surface mass change, e.g. on biosensors
• CPC Class Codes: G01N 2291/0423 Surface waves, e.g. Rayleigh waves, Love waves
• CPC Class Codes: G01N 2291/0426 Bulk waves, e.g. quartz crystal microbalance, torsional waves
• CPC Class Codes: G01N 29/022 Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices microdevices per se B81B

Abstract

Provided is a sensor which integrates a pair of substantially unidirectional surface acoustic wave (SAW) interdigital transducers (IDTs) and a thickness shear mode (TSM) electrode. The sensor provides simultaneous sensing and removal of material from the sensor'"'"'s surface. The sensing aspect is accomplished through the use of the TSM electrode that is designed to operate between 2 and 100 MHz. The removal of material is accomplished using substantially unidirectional IDTs aligned on the substrate to produce acoustic waves, such as Rayleigh waves, across the entire TSM sensor active area. When liquid is added over the acoustic waves, acoustic streaming occurs, which dislodges material from the sensor'"'"'s surface. The acoustic waves are designed to operate at a significantly different frequency than the sensor to prevent interference between the two.

Claims

1. A sensor, comprising:

a substrate;

a pair of substantially unidirectional surface acoustic wave (SAW) interdigital transducers (IDTs) on the substrate aligned to create an acoustic path that propagates an acoustic wave therebetween; and

a thickness shear mode (TSM) electrode on the substrate positioned in the acoustic path between the pair of SAW IDTs.

2. The sensor of claim 1, further comprising:

a second TSM electrode on a second side of the substrate.

3. The sensor of claim 1, wherein the substrate is selected from the group consisting of quartz, lithium niobate, lithium tantalate, and langasite.

4. The sensor of claim 1, wherein the IDTs are of sized to expose the entire surface of the TSM electrode to the acoustic wave.

5. A method of simultaneously sensing a material and removing analytes from a sensor'"'"'s surface comprising:

providing a sensor comprising;

a substrate,

a pair of substantially unidirectional SAW IDTs on the substrate aligned to create an acoustic path that propagates an acoustic wave therebetween, and

a TSM electrode on the substrate positioned in the acoustic path between the pair of SAW IDTs;

operating the TSM electrode between 2 and 100 MHz whereby sensing of the material occurs;

producing acoustic waves along the acoustic path and across the TSM electrode using the pair of SAW IDTs; and

adding a liquid over the acoustic waves to induce acoustic streaming whereby analytes are dislodged from the sensor'"'"'s surface.

6. The method of claim 5, wherein the sensor further comprises a second TSM electrode on a second side of the substrate.

7. The method of claim 5, wherein the substrate of the sensor is selected from the group consisting of quartz, lithium niobate, lithium tantalate, and langasite.

8. The method of claim 5, wherein the IDTs of the sensor are sized to expose the entire surface of the TSM electrode to the acoustic wave.

9. The method of claim 5, wherein the acoustic waves are Rayleigh waves.