Self-calibrating rate-adaptive pacemaker

• US 8,019,418 B2
• Filed: 07/22/2009
• Issued: 09/13/2011
• Est. Priority Date: 09/08/2000
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Sun, Weimin, Jones, Bruce R., Lang, Douglas J., Hopper, Donald L.
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US12/507,414
• Publication Number:
  US 20090287270A1
• Time in Patent Office: 783 Days
• Field of Search: 607/9, 607 17- 20, 607/27
• US Class Current: 607/19
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

Claims

1. A rate-adaptive pacemaker, comprising:

a sensor adapted to sense exertion levels; and

a microprocessor coupled to the sensor, the microprocessor adapted to;

collect short-term maximum exertion levels;

update a long-term maximal exertion level periodically by setting the long-term maximal exertion level to a maximum of the short-term maximum exertion levels collected during a specified time period; and

adjust a response factor, the response factor being a slope of a rate response curve mapping exertion levels to sensor indicated rates, wherein the response factor is adjusted such that the updated long-term maximal exertion level is mapped to a specified maximum sensor indicated rate.

2. The pacemaker of claim 1, wherein the rate response curve is a dual-slope curve, and the response factor changes from a low rate response factor to a high rate response factor at a heart rate breakpoint computed as a percentage of a rate reserve being a difference between maximum and minimum sensor indicated rates defined by the rate response curve, and the microprocessor is adapted to adjust the response factor with the heart rate breakpoint maintained at a fixed percentage of the rate reserve.

3. The pacemaker of claim 1, wherein the rate response curve is a dual-slope curve, and the response factor changes from a low rate response factor to a high rate response factor at a heart rate breakpoint computed as a percentage of a rate reserve being a difference between maximum and minimum sensor indicated rates defined by the rate response curve, and the microprocessor is adapted to adjust the response factor with the heart rate breakpoint maintained at a dynamic percentage of the rate reserve that changes with the long-term maximum exertion level.

4. The pacemaker of claim 1, wherein the microprocessor is further adapted to:

collect short-term maximum sensor indicated rates;

compute an intermediate-term average maximum sensor indicated rate being an average of the short-term maximum sensor indicated rates collected during a specified intermediate-term period;

compute an intermediate-term average maximum exertion level being an average of the short-term maximum exertion levels collected during the specified intermediate-term period;

compute a sensor target rate as a function of the intermediate-term average maximum exertion level and the long-term maximum exertion level; and

adjust the slope of the rate response curve using the intermediate-term average maximum sensor indicated rate and the sensor target rate.

5. The pacemaker of claim 4, wherein the sensor is adapted to sense a signal being an approximation to oxygen consumption.

6. The pacemaker of claim 5, wherein the sensor comprises a minute ventilation sensor.

7. The pacemaker of claim 4, wherein the sensor comprises an accelerometer.

8. The pacemaker of claim 4, wherein the microprocessor is adapted to adjust the slope of the rate response curve periodically using a difference between the intermediate-term average maximum sensor indicated rate and the sensor target rate.

9. The pacemaker of claim 8, wherein the microprocessor is adapted to compute moving average values of the sensed exertion levels and moving average values of the sensor indicated rates during a specified short-term period.

10. The pacemaker of claim 9, wherein the specified short-term period is a day, and the specified intermediate-term period is a week.

11. A rate-adaptive pacemaker, comprising:

a sensor adapted to sense exertion levels; and

a microprocessor coupled to the sensor, the microprocessor adapted to;

collect short-term maximum exertion levels and short-term maximum sensor indicated rates;

compute an intermediate-term average maximum exertion level being an average of the short-term maximum exertion levels and an intermediate-term average maximum sensor indicated rate being an average of the short-term sensor indicated rates;

compute a sensor target rate as a function of the intermediate-term average short-term maximum exertion level and a maximum exercise capacity as defined by a long-term maximum exertion level; and

adjust a response factor using the intermediate-term average maximum sensor indicated rate and the sensor target rate, the response factor being a slope of a rate response curve that maps exertion levels to sensor indicated rates.

12. The pacemaker of claim 11, wherein the microprocessor is adapted to adjust the response factor periodically using a difference between the intermediate-term average maximum sensor indicated rate and the sensor target rate.

13. The pacemaker of claim 12, wherein the microprocessor is adapted to compute moving average values of the sensed exertion levels and moving average values of the sensor indicated rates during a specified short-term period.

14. The pacemaker of claim 13, wherein the microprocessor is adapted to adjust the response factor in specified increments.

15. The pacemaker of claim 11, wherein the rate response curve is a dual-slope curve, and the response factor changes from a low rate response factor to a high rate response factor at a heart rate breakpoint computed as a percentage of a rate reserve being a difference between maximum and minimum sensor indicated rates defined by the rate response curve, and the microprocessor is adapted to adjust the low rate response factor using the intermediate-term average maximum sensor indicated rate and the sensor target rate.

16. The pacemaker of claim 15, wherein the microprocessor is adapted to adjust the high rate response factor such that the long-term maximum exertion level is mapped to a specified maximum sensor indicated rate.

17. The pacemaker of claim 11, wherein the microprocessor is adapted to:

update the long-term maximal exertion level periodically by setting the long-term maximal exertion level to a maximum of the short-term maximum exertion levels collected during a specified short-term time period; and

adjust the response factor such that the updated long-term maximal exertion level is mapped to a specified maximum sensor indicated rate.

18. The pacemaker of claim 17, wherein the sensor is adapted to sense a signal being an approximation to oxygen consumption.

19. The pacemaker of claim 18, wherein the sensor comprises a minute ventilation sensor.

20. The pacemaker of claim 17, wherein the sensor comprises an accelerometer.