System for extracting morphological information through a perfusion assessment process

• US 8,021,303 B2
• Filed: 06/25/2007
• Issued: 09/20/2011
• Est. Priority Date: 06/12/2003
• Status: Active Grant

• Current Assignee: Bracco Suisse SA
• Original Assignee: Bracco Research SA
• Inventors: Frinking, Peter, Rognin, Nicolas, Arditi, Marcel
• Primary Examiner(s): Le; Long V.
• Assistant Examiner(s): Hoffa; Angela M
• Application Number:
  US11/823,098
• Publication Number:
  US 20080294027A1
• Time in Patent Office: 1,548 Days
• Field of Search: None
• US Class Current: 600/458
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/13 Tomography A61B8/10, A61B8/12 take precedence; tomography for radiation diagnosis A61B6/02
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039

Abstract

A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a reperfusion of a contrast agent in a body-part of a living subject following destruction of a significant portion of the contrast agent in the body-part, means for associating the echo-power signal to a perfusion function with an S-shape based on a plurality of elementary perfusion functions with said S-shape each one for a corresponding value of at least one perfusion parameter, the elementary perfusion functions being weighted according to a probability density distribution of the at least one perfusion parameter, wherein the S-shape includes an initial portion with substantially zero first derivatives, a final portion with substantially zero first derivatives, and a central portion between the initial portion and the final portion changing monotonically from a value of the initial portion to a value of the final portion, means for determining at least one shape indicator of the probability density distribution, and means for comparing the at least one shape indicator with at least one predetermined further shape indicator to identify morphological characteristics of the body-part according to a result of the comparison.

Claims

1. A perfusion assessment system including:

a device configured to;

provide an echo-power signal indicative of a reperfusion of a contrast agent in a body-part of a living subject following destruction of a significant portion of the contrast agent in the body-part; and

a processor configured to;

associate the echo-power signal to a perfusion function with an S-shape based on a plurality of elementary perfusion functions with said S-shape each one for a corresponding value of at least one perfusion parameter, the elementary perfusion functions being weighted according to a probability density distribution of the at least one perfusion parameter, wherein the S-shape comprises an initial portion with substantially zero first derivatives, a final portion with substantially zero first derivatives, and a central portion between the initial portion and the final portion changing monotonically from a value of the initial portion to a value of the final portion,

determine at least one shape indicator of the probability density distribution,

compare the at least one shape indicator with at least one predetermined further shape indicator to identify morphological characteristics of the body-part according to a result of the comparison.

2. The system according to claim 1, wherein the at least one shape indicator is indicative of a skewness of the probability density distribution.

3. The system according to claim 2, wherein each elementary perfusion function is a cumulative normal distribution function based on a first predetermined parameter indicative of an echo-power signal measure sensitivity and a second predetermined parameter indicative of a contrast agent destruction extent.

4. The system according to claim 2, wherein the processor is further configured to process the echo-power signal to be proportional to a concentration of the contrast agent in the body-part.

5. The system according to claim 2, wherein the associating comprises calculating a temporal sequence of samples representative of the echo-power signal in a region of interest, and fitting the samples by the perfusion function.

6. The system according to claim 1, wherein each elementary perfusion function is a cumulative normal distribution function based on a first predetermined parameter indicative of an echo-power signal measure sensitivity and a second predetermined parameter indicative of a contrast agent destruction extent.

7. The system according to claim 6, wherein the processor is further configured to process the echo-power signal to be proportional to a concentration of the contrast agent in the body-part.

8. The system according to claim 6, wherein the associating comprises for calculating a temporal sequence of samples representative of the echo-power signal in a region of interest, and fitting the samples by the perfusion function.

9. The system according to claim 1, wherein the processor is further configured to process the echo-power signal to be proportional to a concentration of the contrast agent in the body-part.

10. The system according to claim 1, wherein the associating comprises calculating a temporal sequence of samples representative of the echo-power signal in a region of interest, and fitting the samples by the perfusion function.

11. The system according to claim 1, wherein the probability density distribution is a lognormal function of the at least one perfusion parameter and the perfusion function comprises the integral of the elementary perfusion functions multiplied by the lognormal function, the perfusion function being represented by a set of fitting parameters, and wherein the determining the at least one shape indicator comprises calculating the at least one shape indicator from the fitting parameters.

12. The system according to claim 1, wherein the probability density distribution is represented by a vector of probabilities, the perfusion function including the summation of the elementary perfusion functions multiplied by the corresponding probabilities, and wherein the determining the at least one shape indicator comprises calculating the at least one shape indicator from the vector of probabilities.

13. The system according to claim 12, wherein the associating comprises determining a first estimate of the vector of probabilities by minimizing an error function between the echo-power signal and the perfusion function, the first estimate including a first number of elements, extrapolating a second estimate of the vector of probabilities from the first estimate, the second estimate including a second number of elements higher than the first number, and determining a third estimate of the vector of probabilities by a neural network being initialized according to the second estimate.

14. The system according to claim 13, wherein the neural network comprises a synapsis based on a plurality of weights corresponding to the vector of probabilities, the determining the third estimate including training the neural network by iteratively adjusting the weights according to the echo-power signal and corresponding evaluations of the elementary perfusion functions for a predefined set of values of the at least one parameter, and periodically resetting the weights.

15. The system according to claim 1, wherein the at least one further shape indicator relates to a further body-part of the living subject being in a healthy condition.

16. The system according to claim 1, wherein the at least one further shape indicator relates to the body-part at a time preceding the determination of the at least one shape indicator.

17. A diagnostic imaging equipment including ultrasound means for acquiring the echo-power signal and the perfusion assessment system according to claim 1.

18. A perfusion assessment method including the steps of:

providing an echo-power signal indicative of a reperfusion of a contrast agent in a body-part of a living subject following destruction of a significant portion of the contrast agent in the body-part,

associating the echo-power signal to a perfusion function with an S-shape based on a plurality of elementary perfusion functions with said S-shape each one for a corresponding value of at least one perfusion parameter, the elementary perfusion functions being weighted according to a probability density distribution of the at least one perfusion parameter, wherein the S-shape comprises an initial portion with substantially zero first derivatives, a final portion with substantially zero first derivatives, and a central portion between the initial portion and the final portion changing monotonically from a value of the initial portion to a value of the final portion,

determining at least one shape indicator of the probability density distribution, and

comparing the at least one shape indicator with at least one predetermined further shape indicator to identify morphological characteristics of the body-part according to a result of the comparison.

19. A non-transitory computer readable medium comprising instructions that when carried out by a computer processor, perform the steps of claim 18.