Breath end-tidal gas monitor

• US 8,021,308 B2
• Filed: 06/19/2003
• Issued: 09/20/2011
• Est. Priority Date: 06/19/2003
• Status: Active Grant

• Current Assignee: Soleno Therapeutics, Inc.
• Original Assignee: Capnia, Inc.
• Inventors: Causevic, Elvir, Walden, Ralph, Carlson, Lee R., McClatchie, Edward A., Martinosky, Joe
• Primary Examiner(s): Mallari; Patricia C
• Assistant Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US10/561,561
• Publication Number:
  US 20060241507A1
• Time in Patent Office: 3,015 Days
• Field of Search: 600/529, 600/532, 600/538, 600/543
• US Class Current: 600/532
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/0833 Measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: G01N 33/004 CO or CO2
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath
• CPC Class Codes: Y10S 436/90 Breath testing

Abstract

An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO₂ level of air drawn into the system (10) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO₂ level in the air drawn into the system (10), indicating a transition between exhalation and inhalation a pair of flow selector valves (26, 28) are operated to capture the end-tidal volume of air drawn into the system (10) immediately prior to the detection of the decrease in the CO₂ level. Incoming air is diverted around the captured volume of air, and the CO₂ levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer (44) for analysis of one or more predetermined gas levels.

Claims

1. A method for capturing and analyzing the end-tidal portion of an exhalation, including the steps of:

drawing a flow of air from the breath of a patient;

monitoring the CO₂ level of said flow of air;

identifying a point of transition between an increasing CO₂ level and a decreasing CO₂ in said flow of air, said point of transition representative of a change from exhalation to inhalation in the breath of said patient;

upon identification of said transition point, isolating a sample volume of said flow of air drawn prior to said transition point;

diverting a continued flow of air past the isolated sample volume;

monitoring the CO₂ level of said continued flow of air to confirm said change from exhalation to inhalation in the breath of said patient;

upon confirmation of said change from exhalation to inhalation in the breath of said patient, diverting said continued flow of air to displace said isolated sample volume through at least one gas measurement component; and

measuring using a gas analyzer, at least one gas level in said isolated sample volume.

2. A periodic gas pattern analyzer having a pump configured to draw a flow of gas through a detector, the detector adapted to identify a threshold level of a periodic element or component in the gas, and to subsequently direct the flow of gas through at least one gas analyzer, comprising:

a branching component disposed downstream from the detector, said branch component configured to direct the flow of gas through a sample volume to said pump and to through a bypass around said sample volume to said pump;

a first flow selector valve disposed downstream from said branching component, said first flow selector valve configured to isolate said sample volume from said branching component;

a second flow selector valve disposed downstream from said first flow selector valve, said second flow selector valve configured to receive said bypass flow of gas from said branching component and to isolate said sample volume from said pump;

a third flow selector valve disposed downstream from said pump, said third flow selector valve configured to selectively exhaust said flow of gas and to route said flow of gas into said isolated sample volume; and

wherein said first flow selector valve is further configured to selectively couple said sample volume to said at least one gas analyzer.

3. The periodic gas pattern analyzer of claim 2 wherein said first flow selector valve and said second flow selector valve are responsive to signals from said detector to isolate said sample volume from said branching component and from said pump.

4. The periodic gas pattern analyzer of claim 2 wherein said third flow selector valve is responsive to signals from said detector to route said flow of gas into said isolated sample volume.

5. The periodic gas pattern analyzer of claim 4 wherein said third flow selector valve is responsive to signals from said detector to route said flow of gas through a one-way valve into said isolated sample volume.

6. The periodic gas pattern analyzer of claim 2 wherein said first flow selector valve is responsive to signals from said detector to couple said sample volume to the at least one gas analyzer.

7. The breath gas analyzer of claim 2 further including a microprocessor configured to receive signals from said detector and to control operation of each of said flow selector valves responsive to said received signals.

8. A method for capturing and analyzing a portion of a time-varying gas pattern, including the steps of:

drawing a flow of gas from the time-varying gas pattern;

monitoring a level of a periodic element of said flow of gas;

identifying a transition in said flow of gas, said transition corresponding to said level of a periodic element reaching a predetermined threshold;

upon identification of said transition, isolating a sample volume of said flow of gas drawn prior to said transition point;

diverting a continued flow of air past the isolated sample volume;

monitoring the level of said periodic element of said continued flow of gas to confirm said transition;

upon confirmation of said transition, diverting said continued flow of air to displace said isolated sample volume through at least one gas measurement component; and

measuring, using a gas analyzer, at least one gas level in said isolated sample volume.