Versatile method of repairing an intervertebral disc

• US 8,021,425 B2
• Filed: 07/21/2009
• Issued: 09/20/2011
• Est. Priority Date: 08/18/1999
• Status: Expired due to Fees

• Current Assignee: Intrinsic Therapeutics, Inc.
• Original Assignee: Intrinsic Therapeutics, Inc.
• Inventors: Lambrecht, Gregory H.
• Primary Examiner(s): Stewart; Alvin J.
• Application Number:
  US12/507,020
• Publication Number:
  US 20090281517A1
• Time in Patent Office: 791 Days
• Field of Search: 623 1711- 1716, 623/2.36, 606/263, 606/279, 606/62, 606/139, 606/144, 606/232, 600/16, 600/37
• US Class Current: 623/17.11
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/320016 Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes A61B10/0233, A61B17/29, A61B17/3207 take precedence
• CPC Class Codes: A61B 17/320708 Curettes, e.g. hollow scraping instruments
• CPC Class Codes: A61B 17/70 Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
• CPC Class Codes: A61B 2017/00261 Discectomy
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61B 2017/044 with a threaded shaft, e.g. screws
• CPC Class Codes: A61B 2017/22077 with a part piercing the tissue A61B2017/22044 takes precedence
• CPC Class Codes: A61B 2017/320044 Blunt dissectors
• CPC Class Codes: A61B 2017/3445 used as instrument channel for multiple instruments
• CPC Class Codes: A61B 2090/061 for measuring dimensions, e.g. length
• CPC Class Codes: A61B 2090/062 penetration depth
• CPC Class Codes: A61B 5/1076 for measuring dimensions inside body cavities, e.g. using catheters A61B3/1005 takes precedence
• CPC Class Codes: A61B 5/4514 Cartilage
• CPC Class Codes: A61F 2/2846 Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006
• CPC Class Codes: A61F 2/30723 Plugs or restrictors for sealing a cement-receiving space tools for inserting plugs A61F2/4614; sealing collars for use during cementing A61B17/8808
• CPC Class Codes: A61F 2/30907 Nets or sleeves applied to surface of prostheses or in cement
• CPC Class Codes: A61F 2/441 made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
• CPC Class Codes: A61F 2/442 Intervertebral or spinal discs, e.g. resilient non-disc-shaped intervertebral inflatable pockets A61F2/441; non-disc-shaped intervertebral fusion implants A61F2/4455
• CPC Class Codes: A61F 2/4455 for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages intervertebral discs A61F2/442
• CPC Class Codes: A61F 2/4601 : for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
• CPC Class Codes: A61F 2/4611 : of spinal prostheses
• CPC Class Codes: A61F 2/4657 : Measuring instruments used for implanting artificial joints for surgical instruments A61B90/06
• CPC Class Codes: A61F 2002/2817 : Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/30062 : (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30075 : swellable, e.g. when wetted
• CPC Class Codes: A61F 2002/30131 : horseshoe- or crescent- or C-shaped or U-shaped
• CPC Class Codes: A61F 2002/30224 : cylindrical
• CPC Class Codes: A61F 2002/30228 : Cylinders of elliptical or oval basis
• CPC Class Codes: A61F 2002/30291 : spirally-coiled, i.e. having a 2D spiral cross-section
• CPC Class Codes: A61F 2002/30462 : retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2002/30571 : Leaf springs
• CPC Class Codes: A61F 2002/30583 : filled with hardenable fluid, e.g. curable in-situ
• CPC Class Codes: A61F 2002/30589 : Sealing means
• CPC Class Codes: A61F 2002/30677 : Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30777 : Oblong apertures
• CPC Class Codes: A61F 2002/30785 : parallel
• CPC Class Codes: A61F 2002/4435 : Support means or repair of the natural disc wall, i.e. annulus, e.g. using plates, membranes or meshes
• CPC Class Codes: A61F 2002/444 : for replacing the nucleus pulposus
• CPC Class Codes: A61F 2002/448 : comprising multiple adjacent spinal implants within the same intervertebral space or within the same vertebra, e.g. comprising two adjacent spinal implants
• CPC Class Codes: A61F 2002/4615 : of spacers
• CPC Class Codes: A61F 2002/4627 : with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
• CPC Class Codes: A61F 2002/4635 : using minimally invasive surgery
• CPC Class Codes: A61F 2002/4658 : for measuring dimensions, e.g. length
• CPC Class Codes: A61F 2002/4661 : for measuring thickness
• CPC Class Codes: A61F 2002/4662 : for measuring penetration depth
• CPC Class Codes: A61F 2210/0004 : bioabsorbable
• CPC Class Codes: A61F 2210/0061 : swellable
• CPC Class Codes: A61F 2210/0085 : hardenable in situ, e.g. epoxy resins
• CPC Class Codes: A61F 2220/0075 : sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0013 : Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2230/0091 : helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2310/00017 : Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 : Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00029 : Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
• CPC Class Codes: A61F 2310/00293 : containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00365 : Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61F 2310/0097 : Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
• CPC Class Codes: A61F 2310/00976 : Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF

Abstract

Systems for minimally invasive disc augmentation include an anulus augmentation component and, optionally, a nucleus augmentation component. Both are suited for minimally invasive deployment. The anulus augmentation component shields weakened regions of the anulus fibrosis and/or resists escape of natural nucleus pulposus and/or the nucleus augmentation component. Methods and deployment devices are also disclosed. Systems and methods for closing a defect in the anulus are also provided.

Claims

1. A versatile method of treating an intervertebral disc having a weakened anulus segment comprising:

identifying a functional spine unit comprising an intervertebral disc having a weakened anulus segment, a superior vertebral body, and an inferior vertebral body;

wherein the weakened anulus segment comprises a protruding herniated segment implanting a biocompatible support member and an anchor,

wherein said anchor is configured to be anchored within bone or soft tissue of said functional spine unit;

positioning said support member to, within or posterior to said weakened anulus segment;

anchoring said anchor to a site within the functional spine unit;

connecting said support member to said anchor with a connection member; and

applying tension and tightening said connection member, thereby retaining and supporting said weakened anulus segment and returning said herniated segment to a pre-herniated border.

2. The method of claim 1, wherein said support member is positioned to contact an innermost surface of an anulus of an intervertebral disc adjacent the weakened anulus segment.

3. The method of claim 1, wherein said support member comprises a second anchor.

4. The method of claim 1, wherein anchoring said anchor into a site within the functional spine unit comprises anchoring said anchor within anulus tissue of the intervertebral disc.

5. The method of claim 4, wherein said anulus tissue is within or adjacent to the weakened anulus segment.

6. The method of claim 1, wherein anchoring said anchor into a site within the functional spine unit comprises anchoring said anchor within one of the superior vertebral body and the inferior vertebral body.

7. The method of claim 1, wherein said connection member comprises a suture.

8. The method of claim 1, wherein said connection member comprises woven material.

9. The method of claim 1, wherein said weakened anulus segment comprises a pre-existing defect.

10. The method of claim 9, wherein supporting said weakened anulus segment comprises closing the pre-existing defect.

11. The method of claim 1, wherein said connection member is coupled with at least one of said support member or said anchor.

12. A versatile method of treating an intervertebral disc having a weakened anulus segment comprising:

identifying a functional spine unit comprising an intervertebral disc having a weakened anulus segment, a superior vertebral body, and an inferior vertebral body;

wherein the weakened anulus segment comprises a protruding herniated segment,

implanting a biocompatible support member and an anchor,

positioning said support member to, within or posterior to said weakened anulus segment;

anchoring said anchor to a site within the functional spine unit;

connecting said support member to said anchor with a connection member, wherein the connection member comprises a suture; and

applying tension and tightening said connection member, thereby retaining and supporting said weakened anulus segment and returning said herniated segment to a pre-herniated border.

13. The method of claim 12, wherein the support member comprises a second anchoring device.

14. The method of claim 12, wherein the support member is positioned on an inner surface of the anulus adjacent to the nucleus.

15. The method of claim 12, further comprising the step of closing a hole in said weakened anulus segment.

16. The method of claim 12, wherein said anchoring device is configured to be positioned within bone tissue or soft tissue of said functional spine unit.