Method for producing microparticles in a continuous phase liquid

• US 8,021,582 B2
• Filed: 08/26/2009
• Issued: 09/20/2011
• Est. Priority Date: 01/23/2006
• Status: Expired due to Fees

• Current Assignee: National Cheng KUNG University (Government of The Republic of China)
• Original Assignee: National Cheng KUNG University (Government of The Republic of China)
• Inventors: Chen, Cheng-Tso, Lee, Gwo-Bin
• Primary Examiner(s): THEISEN, MARY LYNN F
• Application Number:
  US12/548,365
• Publication Number:
  US 20090315203A1
• Time in Patent Office: 755 Days
• Field of Search: None
• US Class Current: 264/9
• CPC Class Codes: B01F 23/41 Emulsifying
• CPC Class Codes: B01F 31/29 Mixing by periodically deforming flexible tubular members through which the material is flowing
• CPC Class Codes: B01F 33/3011 using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 2219/00783 Laminate assemblies, i.e. the reactor comprising a stack of plates
• CPC Class Codes: B01J 2219/00831 Glass
• CPC Class Codes: B01J 2219/00833 Plastic
• CPC Class Codes: B01J 2219/00889 Mixing
• CPC Class Codes: B01J 2219/00907 using membranes

Abstract

A continuous phase liquid and a dispersed phase liquid are permitted to flow together through a co-flow channel. Preferably, the dispersed phase liquid is arranged to flow within the flowing body of the continuous phase liquid in the co-flow channel so that the dispersed phase liquid is sheathed by the continuous phase liquid. The continuous phase and dispersed phase liquids are comminuted into microparticles in the co-flow channel by intermittently blocking the co-flow channel.

Claims

1. A method of producing microparticles, comprising:

(a) providing a co-flow channel having upstream and downstream ends;

(b) causing a dispersed phase liquid to flow into a flowing body of a continuous phase liquid at the upstream end of the co-flow channel, and allowing the dispersed phase liquid to flow into the co-flow channel together with the continuous phase liquid, wherein the dispersed phase liquid is sheathed by the continuous phase liquid within the co-flow channel; and

(c) comminuting the continuous phase and dispersed phase liquids in the co-flow channel by intermittently moving a comminuting unit transversely into the co-flow channel to block the co-flow channel at intervals, wherein the microparticles of the dispersed phase liquid are formed within the continuous phase liquid.

2. The method of claim 1, wherein the step (b) includes:

providing at least two first microchannels, and at least one second microchannel, the first microchannels extending on two sides of the second microchannel and meeting the same at the upstream end of the co-flow channel;

allowing the continuous phase liquid to flow through the first microchannels; and

allowing the dispersed phase liquid to flow through the second microchannel,

wherein the dispersed phase liquid is sheathed by the continuous phase liquid within the co-flow channel.

3. The method of claim 1, further comprising providing a collection chamber for collecting the microparticles at downstream of the co-flow channel.

4. The method of claim 1, wherein the comminuting unit includes a plurality of substantially parallel pressurizing channels extending transversely over the co-flow channel, and a membrane extending between the pressurizing channels and the co-flow channel, and wherein step (c) includes applying a pressure to the pressurizing channels simultaneously so that the pressurizing channels simultaneously pressurize the membrane and the co-flow channel is blocked at a plurality of spaced apart points simultaneously.

5. The method of claim 4, wherein the comminuting unit further includes a pressure inlet hole, and a pressure supply channel connecting the pressure inlet hole to all of the pressurizing channels.