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Detection of chromosomal abnormalities associated with breast cancer

  • US 8,021,837 B2
  • Filed: 02/24/2006
  • Issued: 09/20/2011
  • Est. Priority Date: 03/04/1992
  • Status: Expired due to Fees
First Claim
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1. A method for detecting a copy number variation by detecting an amplification or gain of unique sequences at the chromosomal region of position q13 on chromosome 20 in a suspected breast cancer test sample from a subject, said method comprising:

  • (a) contacting a probe that binds selectively to a target polynucleotide sequence of said region with a nucleic acid sample prepared, directly or indirectly, from said test sample, wherein said nucleic acid sample comprises said target polynucleotide sequence and said probe is contacted with said sample under conditions in which said probe forms a stable hybridization complex with said target nucleic acid sequence; and

    (b) detecting said hybridization complex to detect said amplification or gain of said chromosomal region.

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