Modified human plasma polypeptide or Fc scaffolds and their uses

• US 8,022,186 B2
• Filed: 10/29/2007
• Issued: 09/20/2011
• Est. Priority Date: 09/08/2006
• Status: Expired due to Fees

• Current Assignee: Ambrx, Inc. (Johnson & Johnson)
• Original Assignee: Ambrx, Inc. (Johnson & Johnson)
• Inventors: Tian, Feng, Cho, Ho Sung, Dimarchi, Richard D., Norman, Thea, Krawitz, Denise, Hays Putnam, Anna-Maria A., Chu, Stephanie, Sheffer, Joseph
• Primary Examiner(s): Bunner; Bridget E
• Assistant Examiner(s): HAMUD, FOZIA M
• Application Number:
  US11/927,139
• Publication Number:
  US 20080125574A1
• Time in Patent Office: 1,422 Days
• Field of Search: None
• US Class Current: 530/363
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C07K 14/765 Serum albumin, e.g. HSA
• CPC Class Codes: C07K 19/00 Hybrid peptides , i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
• CPC Class Codes: C07K 2319/00 Fusion polypeptide

Abstract

Modified human plasma polypeptides or Fc and uses thereof are provided.

Claims

1. A human serum albumin (HSA) comprising a non-naturally encoded amino acid at one of the following positions:

34, 82, 172, 301, 364, and 505 of SEQ ID NO;

1, linked to one or more pancreatic hormone.

2. The HSA of claim 1, wherein the one or more pancreatic hormone is selected from the group consisting of insulin, amylin, pancreastatin, and glucagon.

3. The HSA of claim 2, wherein the pancreatic hormone is an insulin-like peptide.

4. The HSA of claim 2, wherein the pancreatic hormone is insulin.

5. The HSA of claim 2, wherein the pancreatic hormone is amylin.