Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
First Claim
Patent Images
1. A method of treating abnormal tissue growth, comprising:
- implanting a first electrode at the site of the abnormal tissue growth;
implanting a generator that functions as a second electrode at a position at least about 5 cm away from the abnormal tissue growth from the abnormal tissue growth;
administering a therapeutic agent having an electrical charge near the second electrode;
applying a first form of electrical therapy at a voltage of between about 3V to 5V between the first and second electrodes in which the second electrode is provided with a polarity similar to the charge of the therapeutic agent and the first electrode is provided with a polarity dissimilar to the charge of the therapeutic agent so that the first form of electrical therapy is effective for causing said therapeutic agent to migrate through bodily tissue to the first electrode implanted at the site of the abnormal tissue growth,administering a second form of electrical therapy between the first and second electrodes effective for achieving electroporation of cellular membranes, said second form of electrical therapy being delivered at a voltage between about 200 V and about 1300 V;
wherein the first form of electrical therapy is applied for a sufficient amount of time to cause a change in pH of at least about 2 at the site of the abnormal tissue growth.
2 Assignments
0 Petitions
Accused Products
Abstract
A method for the electrical treatment of malignant tumors and neoplasms by applying a voltage to affected tissue. Devices and various adaptations therein are described for use in electrical therapy. Additionally, various chemotherapeutic agent and radiation therapies are described which may be advantageously used in conjunction with electrical therapy to ameliorate cancer.
75 Citations
38 Claims
-
1. A method of treating abnormal tissue growth, comprising:
-
implanting a first electrode at the site of the abnormal tissue growth; implanting a generator that functions as a second electrode at a position at least about 5 cm away from the abnormal tissue growth from the abnormal tissue growth; administering a therapeutic agent having an electrical charge near the second electrode; applying a first form of electrical therapy at a voltage of between about 3V to 5V between the first and second electrodes in which the second electrode is provided with a polarity similar to the charge of the therapeutic agent and the first electrode is provided with a polarity dissimilar to the charge of the therapeutic agent so that the first form of electrical therapy is effective for causing said therapeutic agent to migrate through bodily tissue to the first electrode implanted at the site of the abnormal tissue growth, administering a second form of electrical therapy between the first and second electrodes effective for achieving electroporation of cellular membranes, said second form of electrical therapy being delivered at a voltage between about 200 V and about 1300 V; wherein the first form of electrical therapy is applied for a sufficient amount of time to cause a change in pH of at least about 2 at the site of the abnormal tissue growth. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. A method of treating abnormal tissue growth, comprising:
-
implanting a first electrode at the site of the abnormal tissue growth; implanting a second electrode at a position at least about 5 em away from the abnormal tissue growth; implanting a third electrode less than 5 cm away from the abnormal tissue growth; administering a therapeutic agent near the second electrode; applying a first form of electrical therapy between the first and second electrodes so that the first electrode has a first polarity and the second electrode has a second, opposite polarity, the first form of electrical therapy effective for attracting said therapeutic agent to the first electrode implanted near the site of the abnormal tissue growth, said first form of electrical therapy being delivered at a voltage of between about 1V and about 5Vi administering a second form of electrical therapy between the first and third electrodes effective for achieving electroporation of cellular membranes, said second form of electrical therapy being delivered at a voltage between about 200 V and about 1300 Vi and administering a third form of electrical therapy wherein the polarities of the first and second electrodes are reversed and electrical therapy is delivered at about 1 V to about 2 V to disperse the therapeutic agent throughout the abnormal tissue growth, and administering a fourth form of electrical therapy between the first electrode and the third electrode for a sufficient amount of time to cause a change in pH of at least about 2 at the site of the abnormal tissue growth in order to cause ablation. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
-
-
33. A method of treating abnormal tissue growth, comprising:
-
implanting a first electrode at the site of the abnormal tissue growth; implanting a generator that functions as a second electrode at a position at a distance from the abnormal tissue growth; administering a therapeutic agent having an electrical charge near the second electrode; applying a first form of electrical therapy at a voltage of between about 3V to 5V between the first and second electrodes in which the second electrode is provided with a polarity similar to the charge of the therapeutic agent and the first electrode is provided with a polarity dissimilar to the charge of the therapeutic agent so that the first form of electrical therapy is effective for causing said therapeutic agent to migrate through bodily tissue to the first electrode implanted at the site of the abnormal tissue growth, administering a second form of electrical therapy between the first and second electrodes effective for achieving electroporation of cellular membranes, said second form of electrical therapy being delivered at a voltage between about 200 V and about 1300 V; wherein the first form of electrical therapy is applied for a sufficient amount of time to cause a change in pH of at least about 2 at the site of the abnormal tissue growth. - View Dependent Claims (34, 35, 36, 37, 38)
-
Specification