Apparatus for thermal therapy of prostate gland with ultrasound energy

• US 8,025,688 B2
• Filed: 03/24/2003
• Issued: 09/27/2011
• Est. Priority Date: 11/13/1992
• Status: Expired due to Fees

• Current Assignee: Dornier MedTech America Incorporated (Temasek Holdings Pte Ltd. (Investment Management)), Regents of the University of California (University of California)
• Original Assignee: Dornier Medical Systems, Inc. (Mercedes-Benz Group AG), Regents of the University of California (University of California)
• Inventors: Burdette, Everette C., Diederich, Chris J.
• Primary Examiner(s): FARAH, AHMED M
• Application Number:
  US10/397,070
• Publication Number:
  US 20040044375A1
• Time in Patent Office: 3,109 Days
• Field of Search: 607/96, 607101-105, 607/113, 607/138, 607/143, 600/437, 600/439, 604/22, 601/2
• US Class Current: 607/96
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2017/00092 using thermocouples
• CPC Class Codes: A61B 2017/00106 ultrasonic
• CPC Class Codes: A61B 2017/00274 Prostate operation, e.g. prostatectomy, turp, bhp treatment
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2017/22065 Functions of balloons dilating A61M29/02
• CPC Class Codes: A61B 2018/00017 with gas
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2090/0472 against ultrasound energy
• CPC Class Codes: A61B 2090/0481 against EM radiation, e.g. microwave
• CPC Class Codes: A61B 2090/049 against light, e.g. laser
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 90/04 Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery protection of eyes against laser radiation A61F9/022
• CPC Class Codes: A61F 2007/0095 with a temperature indicator
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61N 5/04 Radiators for near-field treatment
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: A61N 7/022 : intracavitary

Abstract

An apparatus for applying thermal energy to a prostate gland, comprising a support tube having a longitudinal passageway, a power lead channeled through the longitudinal central passageway and an ultrasound crystal disposed around at least part of the support tube. The ultrasound crystal is coupled to the power lead which provides the power to energize the ultrasound crystal and generate ultrasound energy providing thermal therapy to the prostate gland. The ultrasound crystal further includes inactivated portions for reducing ultrasound energy directed to the rectal wall of the patient. A sealant is disposed in contact with the ultrasound crystal allowing vibration necessary for efficient ultrasound energy radiation for the thermal therapy of the prostate gland.

Claims

1. An apparatus for applying thermal therapy to a prostate gland, the apparatus comprising:

a support tube having a longitudinal central passageway;

a first ultrasound transducer disposed on at least a portion of the support tube to generate ultrasound energy for thermal therapy of the prostate gland; and

a power lead coupled to the first ultrasound transducer;

wherein the first ultrasound transducer is configured to direct the generated ultrasound energy to selectively treat a region of the prostate gland;

wherein the first ultrasound transducer includes a first portion and a second portion, and wherein only the first portion delivers energy so that treatment is directed to a selected region of the prostate gland,

wherein the first ultrasound transducer is scored such that power is only delivered to the first portion of the transducer.

2. An apparatus as recited in claim 1, wherein the transducer is cylindrical in shape;

and

wherein the scores run longitudinally along the length of the first ultrasound transducer, so that the first portion provides a specific radial direction for the delivery of ultrasound energy.

3. An apparatus as recited in claim 1, wherein the first ultrasound transducer is configured such that ultrasound energy is directed in an angular heating pattern.

4. An apparatus as recited in claim 3, wherein first ultrasound transducer is configured such that ultrasound energy is directed away from the rectum.

5. An apparatus as recited in claim 1, wherein the power lead is channeled through the central passageway.

6. An apparatus as recited in claim 1, wherein the first ultrasound transducer has a curvilinear cross-section to focus the generated ultrasound energy at the treatment region.

7. An apparatus as recited in claim 1, wherein the first ultrasound transducer comprises a cross-section having one or more planar surfaces.

8. An apparatus as recited in claim 1, further comprising a non-distensible balloon coupled to the transducer, the balloon configured to expand at a specific length to retain the transducer at the prostate gland.

9. An apparatus for applying thermal therapy to a prostate gland, the apparatus comprising:

a support tube having a longitudinal central passageway;

a first ultrasound transducer disposed on at least a portion of the support tube;

a power lead coupled to the first ultrasound transducer to generate ultrasound energy for thermal therapy of the prostate gland; and

means for directing the generated ultrasound energy to selectively treat a region of the prostate gland;

wherein the first ultrasound transducer includes a first portion and a second portion, and wherein the means for directing the generated ultrasound energy further comprises means for activating only the first portion so that treatment is directed to a selected region of the prostate gland.

10. An apparatus as recited in claim 9, wherein the means for directing the generated ultrasound energy radially directs the ultrasound energy to create an angular heating pattern.

11. An apparatus as recited in claim 9, further comprising means for delivering a cooling fluid to the ultrasound applicator transducer to cool a non-target region of the patient.

12. An apparatus for applying thermal therapy to a prostate gland, the apparatus comprising:

a support tube having a longitudinal central passageway;

a first ultrasound transducer disposed on at least a portion of the support tube to generate ultrasound energy for thermal therapy of the prostate gland; and

a power lead coupled to the first ultrasound transducer;

wherein the first ultrasound transducer is configured to direct the generated ultrasound energy to selectively treat a region of the prostate gland;

wherein the first ultrasound transducer includes a first portion and a second portion, and wherein only the first portion delivers energy so that treatment is directed to a selected region of the prostate gland; and

an outer electrode surface surrounding the ultrasound transducer.

13. An apparatus as recited in claim 12, wherein a section of the outer electrode surface is removed to expose the first portion of the ultrasound transducer.

14. An apparatus as recited in claim 13, wherein the outer electrode surface is configured to radially direct the ultrasound energy to create an angular heating pattern.

15. An apparatus for applying thermal therapy to a prostate gland, the apparatus comprising:

a support tube having a longitudinal central passageway;

a first ultrasound transducer disposed on at least a portion of the support tube to generate ultrasound energy for thermal therapy of the prostate gland; and

a power lead coupled to the first ultrasound transducer;

wherein the first ultrasound transducer is configured to direct the generated ultrasound energy to selectively treat a region of the prostate gland; and

a second ultrasound transducer adjacent to the first ultrasound transducer along the support member, the first and second ultrasound transducers being electrically isolated from each other, the second ultrasound transducer coupled to a second power lead such that the first and second ultrasound transducers may be powered independently.

16. An apparatus as recited in claim 15, further comprising a plurality ultrasound transducers adjacently disposed along the support member to form an array of transducers, each transducer individually coupled to a corresponding power lead such that the length and position of the ultrasound energy may be selectively controlled.

17. An apparatus as recited in claim 15, further comprising a sealant disposed between the first and second ultrasound transducers and the support tube.

18. An apparatus as recited in claim 15, wherein the first and second ultrasound transducers comprise cylindrical crystals concentrically disposed about the support tube.

19. An apparatus for applying thermal therapy to a prostate gland, the apparatus comprising:

a support tube having a longitudinal central passageway;

a first ultrasound transducer disposed on at least a portion of the support tube to generate ultrasound energy for thermal therapy of the prostate gland; and

a power lead coupled to the first ultrasound transducer;

wherein the first ultrasound transducer is configured to direct the generated ultrasound energy to selectively treat a region of the prostate gland; and

an outer cover disposed over the first ultrasound transducer, and a fluid disposed between the transducer and the outer cover, the fluid providing efficient coupling of the ultrasound energy into the prostate gland.

20. An apparatus as recited in claim 19, further comprising means to cycle the fluid to selectively cool a non-target region of the patient.

21. An apparatus for applying thermal therapy to a prostate gland, the apparatus comprising:

a support tube having a longitudinal central passageway;

a first ultrasound transducer disposed on at least a portion of the support tube to generate ultrasound energy for thermal therapy of the prostate gland; and

a power lead coupled to the first ultrasound transducer;

wherein the first ultrasound transducer is configured to direct the generated ultrasound energy to selectively treat a region of the prostate gland;

wherein the first ultrasound transducer includes a first portion and a second portion; and

wherein the first portion and the second portion are individually powered so that either the first portion or the second portion provide specific radial direction for the delivery of ultrasound energy to a selected region of the prostate gland.

22. An apparatus as recited in claim 21, wherein the first portion and the second portion are individually powered to provide dynamic control of the radial energy delivery.

23. An apparatus for applying thermal therapy to a prostate gland, the apparatus comprising:

a support tube having a longitudinal central passageway;

a first ultrasound transducer disposed on at least a portion of the support tube;

a power lead coupled to the first ultrasound transducer to generate ultrasound energy for thermal therapy of the prostate gland;

means for directing the generated ultrasound energy to selectively treat a region of the prostate gland;

wherein the first ultrasound transducer comprises an outer electrode surface; and

wherein the means for directing the generated ultrasound energy comprises removing a section of the outer electrode surface to form the second portion of the ultrasound transducer.

24. An apparatus as recited in claim 23, wherein the means for directing the generated ultrasound energy directs the heating pattern away from the rectum.

25. An apparatus for applying thermal therapy to a prostate gland, the apparatus comprising:

a support tube having a longitudinal central passageway;

a first ultrasound transducer disposed on at least a portion of the support tube;

a power lead coupled to the first ultrasound transducer to generate ultrasound energy for thermal therapy of the prostate gland;

means for directing the generated ultrasound energy to selectively treat a region of the prostate gland; and

a second ultrasound transducer, and a means for controlling delivery of energy between the first and second ultrasound transducers to control the longitudinal extent of the ultrasound energy distribution.