Methods and compositions for control of fetal growth via modulation of relaxin
First Claim
1. A method of increasing intrauterine fetal growth rate, the method comprising administering to a primate in need thereof a therapeutically effective amount of relaxin sufficient to maintain a serum concentration of at least about 1-2 ng/mL in said primate in order to increase fetal growth rate, wherein said relaxin is administered parenterally or by continuous subcutaneous infusion during the second trimester of pregnancy.
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Abstract
The invention relates to the method for treatment, diagnosis and prevention of diseases related to fetal growth and placental insufficiency and comprises methods including inhibiting or increasing relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, and relaxin receptor activity. The invention also relates to screening assays to identify compounds that modulate relaxin and/or relaxin receptor activity. The invention further relates to gene therapy methods utilizing relaxin and relaxin-related sequences for the treatment and prevention of diseases related to fetal growth and placental insufficiency.
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Citations
17 Claims
- 1. A method of increasing intrauterine fetal growth rate, the method comprising administering to a primate in need thereof a therapeutically effective amount of relaxin sufficient to maintain a serum concentration of at least about 1-2 ng/mL in said primate in order to increase fetal growth rate, wherein said relaxin is administered parenterally or by continuous subcutaneous infusion during the second trimester of pregnancy.
Specification