Lead extension with input capabilities

• US 8,027,737 B2
• Filed: 08/01/2007
• Issued: 09/27/2011
• Est. Priority Date: 08/01/2007
• Status: Active Grant

• Current Assignee: IntElect Medical, Inc. (Boston Scientific Corporation)
• Original Assignee: IntElect Medical, Inc. (Boston Scientific Corporation)
• Inventors: Carlton, Keith, Kokones, Scott
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): PORTER, JR, GARY A
• Application Number:
  US11/832,148
• Publication Number:
  US 20090036949A1
• Time in Patent Office: 1,518 Days
• Field of Search: 607/45, 607/115, 607/116, 607/2
• US Class Current: 607/116
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

A lead extension useful in deep brain stimulation treatment includes a body portion having a distal end and a proximal end, wherein the proximal end receives a stimulation signal from a generator. A lead interface is disposed at the distal end to send the stimulation signal to a brain stimulation lead. The lead extension also includes a sensor interface disposed at the distal end to receive an input signal from a sensor that is detached from the stimulation lead and send the input signal to the generator.

Claims

1. A lead extension configured to connect a brain stimulation lead to a neuro-stimulation generator comprising:

a body portion having a distal end, a proximal end, a signal line extending between the proximal end and the distal and, and a multiplexer disposed at the distal end and coupled to the signal line, the proximal end of the extension configured to receive a stimulation signal from the neuro-stimulation generator;

a lead interface disposed at the distal end and configured to send the stimulation signal to the brain stimulation lead; and

an electroencephalogram (EEG) interface having a plurality of EEG connectors disposed on the body portion and configured to receive a plurality of EEG signals from a plurality of EEG sensors, wherein at least one of the plurality of EEG sensors is located on the body portion and the plurality of EEG sensors are configured to send the EEG signals to the neuro-stimulation generator, the multiplexer further coupled to the plurality of EEG connectors and the lead interface, wherein the multiplexer is to selectively couple each of the plurality of EEG connectors and the lead interface to the signal line.

2. The lead extension of claim 1, further including an accelerometer interface disposed on the body portion and configured to receive an acceleration signal from an accelerometer that is detached from the brain stimulation lead and configured to send the acceleration signal to the neuro-stimulation generator, the multiplexer further coupled to the accelerometer interface to selectively couple the accelerometer interface to the signal line.

3. The lead extension of claim 1, wherein the lead interface is configured to receive a lead signal from a lead sensor attached to the brain stimulation lead and configured to send the lead signal to the neuro-stimulation generator.

4. The lead extension of claim 1, wherein the EEG interface includes an electrical interface.

5. The lead extension of claim 4, wherein the electrical interface includes a plurality of electrical connectors.

6. The lead extension of claim 1, wherein the at least one EEG sensor is molded to the distal end of the extension.

7. The lead extension of claim 1, wherein the EEG interface further includes a wireless interface.

8. The lead extension of claim 7, wherein the wireless interface includes a communication module selected from a group comprising a radio frequency module, a WiFi module, a Bluetooth module and a WPAN module.

9. A stimulation system comprising:

a brain stimulation lead; and

a lead extension configured to be coupled to a generator of a stimulation signal and the lead, the lead extension including a body portion having a distal end and a proximal end and configured to receive the stimulation signal from the generator, the lead extension having a lead interface disposed at the distal end and configured to send the stimulation signal to the brain stimulation lead, and a sensor interface disposed on the body portion and configured to receive an input signal from a sensor,

wherein the sensor is a plurality of electroencephalogram (EEG) electrodes,

wherein the sensor interface includes a corresponding plurality of electrical connectors coupled to the plurality of EEG electrodes, wherein at least one of the plurality of EEG electrodes is located on the body portion, and the lead extension further includes a signal line extending between the proximal end and the distal end of the body portion and a multiplexer disposed at the distal end and coupled to the signal line and each of the plurality of electrical connectors, the multiplexer to selectively couple the plurality of electrical connectors to the signal line.

11. The stimulation system of claim 9, wherein the sensor interface is coupled to an additional sensor via a wireless connection.

12. The stimulation system of claim 9, wherein the lead includes a lead sensor attached to the brain stimulation lead, the lead interface configured to receive a lead signal from the lead sensor and configured to send the lead signal to the generator.

13. The stimulation system of claim 9, wherein the sensor interface is coupled to an additional sensor via a remote wired connection.

14. The stimulation system of claim 9, wherein the sensor is molded to the distal end of the extension.

15. The stimulation system of claim 11, wherein the additional sensor is at least one of a subcutaneous lead and a skin electrode.

10. A stimulation system comprising:

a brain stimulation lead; and

a lead extension configured to be coupled to a generator of a stimulation signal and the lead, the lead extension including a body portion having a distal end and a proximal end and configured to receive the stimulation signal from the generator, the lead extension having a lead interface disposed at the distal end and configured to send the stimulation signal to the brain stimulation lead, and a sensor interface disposed on the body portion and configured to receive an input signal from a sensor,

wherein the sensor is a plurality of accelerometers,

wherein the sensor interface includes a corresponding plurality of electrical connectors coupled to the plurality of accelerometers, wherein at least one of the plurality of accelerometers is located on the body portion, and the lead extension further includes a signal line extending between the proximal end and the distal end of the body portion and a multiplexer disposed at the distal end and coupled to the signal line and each of the plurality of electrical connectors, the multiplexer to selectively couple the plurality of electrical connectors to the signal line.

16. A method of neuro-stimulation comprising:

(a) providing a neuro-stimulator coupled to at least one electrode on a brain stimulation lead via a lead extension, the lead extension comprising;

a body portion having a distal end, a proximal end, and a signal line extending between the proximal end and the distal end;

a lead interface disposed at the distal end;

an electroencephalogram (EEG) interface having a plurality of EEG connectors disposed on the body portion in communication with a plurality of EEG sensors, wherein at least one of the plurality of EEG sensors is located on the body portion; and

a multiplexer disposed at the distal end, wherein the multiplexer is coupled to the signal line, the plurality of EEG connectors and the lead interface;

(b) selectively coupling, with the multiplexer, the plurality of EEG connectors to the signal line;

(c) receiving, at the neuro-stimulator, a plurality of EEG signals from the plurality of EEG sensors via the selectively coupled EEG connectors;

(d) generating a stimulation signal with the neuro-stimulator in response to the plurality of EEG signals;

(e) receiving the stimulation signal from the neuro-stimulation generator at the proximal end of the lead extension;

(f) sending the stimulation signal from the lead interface to the brain stimulation lead; and

(g) applying the stimulation signal to a tissue site via the at least one electrode on the brain stimulation lead.

17. The method of claim 16, further comprising sending an input signal from an accelerometer to the generator via the lead extension, the accelerometer is coupled to the lead extension and wherein the input signal includes an acceleration signal.

18. A method of neuro-stimulation comprising:

(a) providing a neuro-stimulator coupled to at least one electrode on a brain stimulation lead via a lead extension, the lead extension comprising;

a body portion having a distal end, a proximal end, and a signal line extending between the proximal end and the distal end;

a lead interface disposed at the distal end;

an electroencephalogram (EEG) interface having a plurality of EEG connectors disposed-on the body portion in communication with a plurality of EEG sensors, wherein at least one of the plurality of EEG sensors is located on the body portion; and

a multiplexer disposed at the distal end, wherein the multiplexer is coupled to the signal line, the plurality of EEG connectors and the lead interface;

(b) generating a stimulation signal with the neuro-stimulator;

(c) selectively coupling, with the multiplexer, the plurality of EEG connectors to the signal line;

(d) receiving, at the neuro-stimulator, an input signal from at least one of the plurality of EEG sensors;

(e) conducting an analysis of the input signal with a processor within the neuro-stimulator;

(f) adjusting a setting of the stimulation signal based on the analysis of the input signal;

(g) receiving the adjusted stimulation signal from the neuro-stimulation generator at the proximal end of the lead extension;

(h) sending the adjusted stimulation signal from the lead interface to the brain stimulation lead; and

(i) applying the adjusted stimulation signal to a tissue site via the at least one electrode on the brain stimulation lead.

19. The method of claim 18, further including repeating steps (d)-(i).