Nucleic acid encoding DR5 antibodies and uses thereof
First Claim
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1. Isolated nucleic acid encoding the heavy or light chain of an anti-DR5 antibody or a functional fragment thereof, wherein:
- (a) said heavy chain comprises the variable domain sequence of 16E2 antibody heavy chain of SEQ ID NO;
11, wherein G at position 33 of CDRH1 is substituted by A, N at position 53 of CDRH2 is substituted by Q, and L at position 102 of CDRH3 is substituted by Y, and(b) said light chain comprises the variable domain sequence of 16E2 antibody light chain of SEQ ID NO;
13, wherein Q at position 24 of CDRL1 is substituted by S, K at position 51 of CDRL2 is substituted by A, and R at position 91 of CDRL3 is substituted by A.
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Abstract
The invention concerns anti-DR5 antibodies with improved properties, compositions comprising such antibodies, methods and means for making such antibodies, and their therapeutic use, in particular in the treatment of cancer.
108 Citations
8 Claims
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1. Isolated nucleic acid encoding the heavy or light chain of an anti-DR5 antibody or a functional fragment thereof, wherein:
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(a) said heavy chain comprises the variable domain sequence of 16E2 antibody heavy chain of SEQ ID NO;
11, wherein G at position 33 of CDRH1 is substituted by A, N at position 53 of CDRH2 is substituted by Q, and L at position 102 of CDRH3 is substituted by Y, and(b) said light chain comprises the variable domain sequence of 16E2 antibody light chain of SEQ ID NO;
13, wherein Q at position 24 of CDRL1 is substituted by S, K at position 51 of CDRL2 is substituted by A, and R at position 91 of CDRL3 is substituted by A. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An isolated nucleic acid encoding the anti-DR5 antibody heavy chain amino acid sequence of SEQ ID NO:
- 18 or light chain amino acid sequence of SEQ ID NO;
20, or a fragment thereof.
- 18 or light chain amino acid sequence of SEQ ID NO;
Specification