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Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)

  • US 8,030,457 B2
  • Filed: 08/22/2008
  • Issued: 10/04/2011
  • Est. Priority Date: 08/23/2007
  • Status: Active Grant
First Claim
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1. An isolated neutralizing antigen binding protein that binds to a PCSK9 protein comprising the amino acid sequence of SEQ ID NO:

  • 1, wherein the neutralizing antigen binding protein comprises;

    a heavy chain polypeptide comprising the following complementarity determining regions (CDRs);

    a heavy chain CDR1 that is a CDR1 in SEQ ID NO;

    49;

    a heavy chain CDR2 that is a CDR2 in SEQ ID NO;

    49;

    a heavy chain CDR3 that is a CDR3 in SEQ ID NO;

    49 and a light chain polypeptide comprising the following CDRs;

    a light chain CDR1 that is a CDR1 in SEQ ID NO;

    23;

    a light chain CDR2 that a CDR2 in SEQ ID NO;

    23; and

    a light chain CDR3 that is a CDR3 in SEQ ID NO;

    23.

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