Plasmodium malariae and Plasmodium ovale genes and uses thereof

• US 8,030,471 B2
• Filed: 06/20/2008
• Issued: 10/04/2011
• Est. Priority Date: 03/06/2008
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Birkenmeyer, Larry G., Desai, Suresh M., Dille, Bruce J., Muerhoff, Anthony S., Dawson, George J.
• Primary Examiner(s): Ford; Vanessa L.
• Assistant Examiner(s): Tongue; Lakia
• Application Number:
  US12/143,137
• Publication Number:
  US 20090226445A1
• Time in Patent Office: 1,201 Days
• Field of Search: None
• US Class Current: 536/23.7
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: A61P 33/02 Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: C07K 14/445 Plasmodium
• CPC Class Codes: G01N 2469/20 Detection of antibodies in sample from host which are directed against antigens from microorganisms
• CPC Class Codes: G01N 2800/26 Infectious diseases, e.g. generalised sepsis
• CPC Class Codes: G01N 33/6893 related to diseases not provided for elsewhere
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.

Claims

1. An isolated nucleic molecule comprising a nucleotide sequence encoding a polypeptide, wherein the amino acid sequence of said polypeptide has at least 90% identity to the amino acid sequence selected from the group consisting of SEQ ID NO:

1, amino acids 1634-1733 of SEQ ID NO;

1, amino acids 1374-1633 of SEQ ID NO;

1 and amino acids 1374-1733 of SEQ ID NO;

1.

2. The isolated nucleic acid molecule of claim 1, wherein said molecule is isolated from Plasmodium malariae.

3. An isolated nucleic acid molecule comprising a nucleotide sequence having at least 90% identity to a nucleic acid sequence comprising the nucleotide sequence selected from the group consisting of SEQ ID NO:

2, nucleotides 62-5317 of SEQ ID NO;

2, nucleotides 4961-5260 of SEQ ID NO;

2, nucleotides 4181-4960 of SEQ ID NO;

2 and nucleotides 4181-5260 of SEQ ID NO;

2.